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As a clinical investigator, Dr. Kiss has been the recipient of federal funding for the past 13 years as a member/grantee of several NHLBI-sponsored research programs, including the Transfusion Medicine Hemostasis/Thrombosis Clinical Trials Network (TMH-CTN), and REDS-II and III programs [REDS is an acronym for Retrovirus(REDS-II) or Recipient (REDS-III) Epidemiology in Donors Study], and through the RO1 award mechanism (STRIDE-Strategies to Reduce Iron Deficiency). His research interests include studies in thrombotic microangiopathies, particularly thrombotic thrombocytopenic purpura (TTP). He served as protocol lead/PI on the multicenter Study of TTP and Rituximab (STAR) trial in 2009. Although the trial was closed early, the study was innovative in its design to utilize immunotherapy (rituximab) up front in a randomized controlled trial in acquired (autoimmune) TTP that has served as a template for other non- randomized studies performed successfully in Europe. He is continuing his research work in TTP as a site PI for caplacizumab, a novel heavy chain monoclonal antibody that blocks VonWillebrand A1domain-platelet receptor Ib binding. He is also pursuing therapies for other thrombotic microangiopathies, such as “TAMOF”, or Thrombocytopenia-associated Multiorgan Failure, with plans for designing a randomized pilot trial utilizing plasma exchange.
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