Department of Medicine
Faculty Profiles by Division

Division of Cardiology

Faculty Profiles

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photo Matthew Francis Muldoon, MD, MPH


Professor of Medicine


Research Interest
Dr. Muldoon conducts clinical research examining the interface of behavioral and biological risk factors for cardiovascular disease. Cardiovascular risk conveyed by hypertension, lipid disorders, insulin resistance and pre-clinical atherosclerosis are studied in relation to individual differences health behaviors (diet and exercise), cognition (attention, working memory, executive function, and impulsivity) and in mood (depression and anxiety). In addition, Dr. Muldoon has tested Interventions to treat or prevent hypertension, including prescribed pharmacotherapies, and nutritional supplements. His most recent work leverages e-health technologies to aid patients in self-management of their hypertension. He has lead or co-lead investigations using randomized and double-blind trial design, physiologic and ambulatory recordings, automated and bidirectional short-messaging systems, biomarker assessment, genomics and functional brain imaging. The majority of Dr. Muldoon’s research funding has come from competitive grants awarded by the National Institutes of Health (US Public Health Service).
Clinical Interest
Dr. Muldoon is a board-certified internist who has long directed the Hypertension Center at the University of Pittsburgh School of Medicine, while also serving as a primary care provider (PCP) at the Pittsburgh VA Healthcare System. He is the founding director of the Heart and Vascular Institute’s Hypertension Center which serves as a regional referral center for severe, secondary and otherwise problematic blood pressure disorders. Here, patients benefit from concurrent assessment and treatment by a certified clinical dietitian and clinical pharmacists as we work collaboratively with patients to optimize BP control through efficient use of both behavioral and pharmacology therapies. We seek discovery of individualized treatment for each patient based upon their medical history and current circumstances, both medical and psychosocial. At the Pittsburgh VA, Dr. Muldoon serves as a senior and widely-experienced primary care provider for a panel of our country’s veterans while also training internal medicine interns and residents in thorough, compassionate and cost-effective general outpatient care.
For my complete bibliography, Click Here.
Selected Publications:
Wong PM, Manuck SB, DiNardo MM, Korytkowski MT, Muldoon MF. Shorter sleep duration is associated with decreased insulin sensitivity in healthy white men. Sleep. 2015; 38: 223-31.
Muldoon MF, Laderian B, Kuan DCH, Sereika SM, Marsland AL, Manuck SB. Fish oil supplementation does not lower serum C-reactive protein or interleukin-6 concentrations in healthy adults. Journal of Internal Medicine. 2015; 279: 98-109.
Muldoon MF, Ryan CM, Yao, JK, Conklin SM, Manuck SB. Long-chain omega-3 fatty acids and optimization of cognitive performance. Military Medicine. 2014; 179(11): 95-105.
Cipollina C, Salvatore SR, Muldoon MF, Freeman BA, Schopfer FJ. Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives. PLoS ONE. 2014; 9: e94836.
Jennings JR, Heim AF, Kuan DC, Gianoros PJ, Muldoon MF, Manuck SB. Utility of total cerebral blood flow as an imaging biomarker of known cardiovascular risks. Stroke. 2013; 44(9): 2480-5.
Muldoon MF, Barger SD, Ryan CM, Flory JD, Lehoczky JP, Matthews KA, Manuck SB. Effects of lovastatin on cognitive function and psychological well-being. American Journal of Medicine. 2000; 108: 538-47.
Muldoon MF, Barger SD, Flory JD, Manuck SB. What are quality of life measurements measuring?. British Medical Journal. 1998; 316: 542-5.
Muldoon MF, Manuck SM, Matthews KM. Lowering cholesterol concentrations and mortality: a quantitative review of primary prevention trials. British Medical Journal. 1990; 301: 309-314.
Ginty A, Muldoon MF, Kuan CHK, Kamarck TK, Jennings JR, Manuck SB, Gianaros PJ. Omega-3 supplementation and the neural correlates of negative affect and impulsivity: A double-blind, randomized, placebo-controlled trial in midlife adults. Psychosomatic Medicine. 2017; 79: 549-556.
Barger SD, Cribbett MR, Muldoon MF. Participant-Reported Health Status Predicts Cardiovascular and All-Cause Mortality Independent of Established and Nontraditional Biomarkers: Evidence From a Representative US Sample. Journal of the American Heart Association. 2016; 5: e003741.
Sponsored Research/Activities
Title: Biobehavioral Studies of Cardiovascular Disease - Core B
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: P01 HL040962
Start Year: 2018
End Year: 2023
Title: Biobehavioral Mechanisms Linking Personality to Health in Midlife
Role: Co-Investigator
Funding Agency: National Institute of Aging
Grant Number: R01 AG056043
Start Year: 2016
End Year: 2021
Title: Omega-3 Polyunsaturated Fatty Acid Status, Microglial Activation, Stress Resilience, and Cognitive Performance
Role: Co-Investigator
Funding Agency: Department of Defense
Grant Number: W81XWH-16-1-0657
Start Year: 2016
End Year: 2019
Notable Achievements
Elected member of the AOA Honor Medical Society, 1983
Masters Degree in Public Health, are of emphasis epidemiology, 1994
Fellow, American Heart Association, 2000
President, American Psychosomatic Society, 2008