Department of Medicine
Faculty Profiles by Division

Division of Infectious Diseases

Faculty Profiles

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photo Matthew Culyba, MD, PhD

Infectious Diseases

Assistant Professor of Medicine


Office: BST E1058
200 Lothrop Street
Pittsburgh, PA 15213
Administrative Assistant:
Jamira Watt
Address: 3550 Terrace Street
Scaife Hall, Room 817
Pittsburgh, PA 15261
Phone: 412-624-9435
Fax: 412-648-8521
Education and Training
BS, University of Rochester, 2002
PhD, Perelman School of Medicine at the University of Pennsylvania, 2008
MD, Perelman School of Medicine at the University of Pennsylvania, 2010
Residency in Internal Medicine, Hospital of the University of Pennsylvania, 2012
Fellowship in Infectious Diseases, Hospital of the University of Pennsylvania, 2016
Research Interest
Dr. Culyba's laboratory fuses molecular and biochemical methodologies with experimental microbial evolution to study mutational phenomena and bacterial adaptation. Mutation and gene transfer events are the source of heritable variation for evolution. These genome diversifying processes can range from being relatively site-specific in the genome to being nearly random. Furthermore, beyond the mutations themselves, the DNA damage and DNA repair events associated with mutagenesis can also be deleterious to the host and are subject to multiple levels of active regulation by cells. Understanding how microorganisms respond to their environments and control the rate and specificity of mutagenesis is the focus of the laboratory. Ongoing studies are aimed at elucidating the (i) molecular mechanisms which regulate mutational phenomena in bacteria during transitions to new environments, (ii) molecular specificity determinants of enzymes involved in mutational phenomena, and (iii) new methods for tracking and detecting mutations in populations of cells. Research projects in the lab are designed to inform a variety of pressing scientific challenges, including combating the crisis of antimicrobial resistance, improving the specificity and safety of cutting-edge gene editing technologies, and building a comprehensive model of molecular evolution.
Clinical Interest
General infectious diseases
Sponsored Research/Activities
Title: Mechanism and Consequences of Temporal Gene Expression for SOS-Induced Mutagenesis
Role: Principal Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: K08 AI127933
Start Year: 2017
End Year: 2021