Department of Medicine
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Division of Infectious Diseases

Faculty Profiles
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photo Bernard JC Macatangay, MD

Infectious Diseases

Associate Director, University of Pittsburgh Immunology Specialty Lab (ACTG)

Email: macatangaybj@upmc.edu

Phone: 412-383-1272
Contact
Office: S827 Scaife Hall
3550 Terrace St
Pittsburgh, PA 15261
 
Phone: 412-383-1272
Fax: 412-648-8457
E-mail: macatangaybj@upmc.edu
Administrative Assistant:
Jamira Watt
Address: 817 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
Email: JRW185@pitt.edu
Phone: 412-624-9435
Fax: 412-648-8521
Education and Training
Education
B.S., Biology, University of the Philippines, 1996
Doctor of Medicine, University of the Philippines, College of Medicine, 2001
Training
Internal Medicine, Roger Williams Medical Center Boston University Program, 2006
General Infectious Diseases, University of Pittsburgh, 2008
HIV/AIDS, University of Pittsburgh, 2010
Research Interest
lmmunoregulatory mechanisms can influence many aspects of the body's immune responses to different antigens, and can control inflammatory responses, thereby preventing pathology caused by persistent immune activation and inflammation. The Macatangay laboratory focuses on various immunoregulatory pathways in different inflammatory states, especially in HIV infection. Specifically, the lab aims to define the role of different immunoregulatory mechanisms in: the inflammatory state associated with chronic HIV infection; HIV persistence; and various HIV immunotherapeutic strategies, such as in therapeutic vaccination. By using specimens obtained from the various studies at the Pittsburgh Treatment and Evaluation Unit (PTEU), the AIDS Clinical Trials Group (ACTG), and the Multicenter AIDS Cohort Study/Women's Interagency HIV Study (MACS/WIHS Combined Cohort Study), the lab assesses the immunophenotype and frequencies of regulatory immune cell subsets. It also analyzes specific suppressive function and components of regulatory pathways to further understand the influence of specific immunoregulatory mechanisms in HIV pathogenesis and persistence. In doing so, Dr. Macatangay aims to improve existing or develop new immunotherapeutic strategies for the control of chronic HIV-associated inflammation and/or for the functional cure of HIV.
Clinical Interest
Dr. Macatangay is an infectious diseases physician who rounds on the General Infectious Diseases Consult Service at UPMC Presbyterian-Montefiore. He also has privileges at Magee Women’s Hospital and UPMC Mercy. Apart from HIV and general infectious diseases, he is interested and has done research in parasitic diseases, specifically, helminthic infections.
Educational Interest
Dr. Macatangay mentors medical students, Internal Medicine residents, and Infectious Diseases Fellows in HIV immunology and parasitology research. He gives lectures on HIV Immunology, HIV Microbiology, Sexually Transmitted Infections, and Helminthic infections to first year medical students, and is a problem-based learning facilitator for Medical Microbiology. He coordinates the Tropical Medicine and Parasitology course for the Internal Medicine Global Health Track residents at UPMC Presbyterian, and provides the Helminthic Infections and HIV Immunology lectures to ID Fellows. He also lectures on the Diagnosis, Treatment, and Prevention of Helminthic Infections to MPH students at the Graduate School of Public Health.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Macatangay BJC, Jackson EK, Abebe KZ, Comer D, Cyktor J, Klamar-Blain C, Borowski L, Gillespie DG, Mellors JW, Rinaldo CR, Riddler SA. A randomized, placebo-controlled, pilot clinical trial of dipyridamole to decrease HIV-associated chronic inflammation. The Journal of Infectious Diseases. 2019; 221(10): 1598-1606.
Macatangay BJC, Gandhi RT, Jones RB, McMahon DK, Lalama CM, Bosch RJ, Cyktor JC, Thomas AS, Borowski L, Riddler SA, Hogg E, Stevenson E, Eron JJ, Mellors JW, Rinaldo CR. T cells with high PD-1 expression are associated with lower HIV-specific immune responses despite long-term antiretroviral therapy. AIDS. 2020; 34(1): 15-24.
Rocco J, Mellors JW, Macatangay BJ. Regulatory T cells: the ultimate HIV reservoir?. Journal of Virus Eradication. 2018; 4(4): 209-214.
Rocco JM, York Z, Shen C, Shiboski C, Cyriaque-Webster J, McLaughlin J, Borowski L, Chen H, Aberg JA, Dittmer DP, Ghannoum M, Rinaldo CR, Macatangay B. Oral cytokine levels are more linked to levels of plasma and oral HIV-1 RNA than with CD4+ T cell counts in people with HIV. Open Forum Infectious Diseases. 2020; 7(3).
Macatangay BJ, Riddler S, Wheeler N, Spindler J, Lawani M, Hong F, Buffo M, Whiteside T, Kearney M, Mellors JW, Rinaldo C. Therapeutic vaccination with dendritic cells loaded with autologous HIV-1-infected apoptotic cells. J Inf Dis. 2016; 213(9): 1400-9.
Macatangay BJC, Szajnik ME, Whiteside TL, Riddler SA, Rinaldo CR. Regulatory T cell suppression of Gag-specific CD8+ T cell polyfunctional response after therapeutic vaccination of HIV-1-infected patients on ART. Regulatory PLoS One. 2010.
Sponsored Research/Activities
Title: The effect of multiple doses of the TLR7 agonist GS-9620 on the HIV-1 reservoir in ART-suppressed viremic controllers
Role: Principal Investigator
Funding Agency: Gilead Sciences, Inc
Start Year: 2019
End Year: 2024
Title: Impact of Poor Sleep on Inflammation and the Adenosine Signaling Pathway in HIV Infection
Role: Co-Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL142118
Start Year: 2018
End Year: 2022
Title: Comparison of Dendritic Cell-Based Therapeutic Vaccine Strategies for HIV Functional Cure
Role: Co-Principal Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: U01 AI131285
Start Year: 2017
End Year: 2022
Title: Dipyridamole as a Modulator of HIV-1 Inflammation by Adenosine Regulation
Role: Co-Principal Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: U01 AI1110410
Start Year: 2014
End Year: 2018
Title: University of Pittsburgh MACS-WIHS CCS
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: U01 HL146208
Start Year: 2019
End Year: 2026
Title: AIDS Clinical Trial Group (ACTG) , Laboratory Center (LC)
Role: Co-Investigator
Funding Agency: University of California Los Angeles / National Institute of Allergy & Infectious Diseases
Grant Number: UM1 AI106701
Start Year: 2019
End Year: 2020
Title: Laboratory Center (LC) AIDS
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: UM1 AI106701
Start Year: 2018
End Year: 2019
Title: Combined Immunologic Approaches to Cure HIV-1 (Virology Core)
Role: Co-Investigator
Funding Agency: Beth Israel Deaconess
Grant Number: UM1 AI126603
Start Year: 2016
End Year: 2017
Title: University of Pittsburgh Multicenter AIDS Cohort Study (MACS)
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: U01 AI035041
Start Year: 2014
End Year: 2019
Title: Longitudinal Evaluation of HIV-Associated Lung Disease Phenotypes
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL125049
Start Year: 2014
End Year: 2018
Title: A Phase 1b, Randomized, Blinded, Placebo-Controlled Dose Escalation Study of the Safety and Biological Activity of GS-9620 in HIV-1 Infected, Virologically Suppressed Adults
Role: Co-Investigator
Funding Agency: Gilead Sciences, Inc
Grant Number: DRUG
Start Year: 2014
End Year: 2018
Title: Aids Clinical Trial Group: Core Funding
Role: Co-Investigator
Funding Agency: Brigham and Women's Hospital, Inc.
Grant Number: UM1 AI068636
Start Year: 2014
End Year: 2017
Title: Pitt-Ohio State - Georgetown Clinical Trials Unit
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: UM1 AI069494
Start Year: 2013
End Year: 2020
Notable Achievements
Excellence in Education Award (Basic Sciences, Small Group Facilitator), University of Pittsburgh School of Medicine, 2015
Golden Apple Award for Teaching Excellence, American Medical Student Association (AMSA), 2017
John Carey Young Investigator Award, AIDS Clinical Trials Group, 2018

Division Websites

Cardiology

Endocrinology and Metabolism

Gastroenterology, Hepatology and Nutrition

General Internal Medicine

Geriatric Medicine
Hematology/Oncology

Infectious Diseases

Pulmonary, Allergy and Critical Care Medicine

Renal-Electrolyte

Rheumatology and Clinical Immunology

Contact

Department of Medicine
1218 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
Email:  chairoff@pitt.edu
Phone:  412-648-9636
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