Department of Medicine
Faculty Profiles by Division

Division of Pulmonary, Allergy and Critical Care Medicine

Faculty Profiles

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photo Timothy E. Corcoran, PhD

Pulmonary, Allergy and Critical Care Medicine

Associate Professor of Medicine, Bioengineering, and Chemical Engineering

Director of Faculty Development

Co-Director, Pulmonary Translational Research Core

Vice Chair of the University of Pittsburgh Institutional Review Board

Interim Associate Chief of Research

Email: corcorante@upmc.edu

Phone: 412-624-8918

Contact
Office: W1256 Starzl Biomedical Science Tower
203 Lothrop Street
Pittsburgh, PA 15213
 
Phone: 412-624-8918
Fax: 412-383-7113
E-mail: corcorante@upmc.edu
Administrative Assistant:
Jackie Harden
Email: hardenja2@upmc.edu
Phone: 412-624-7441
Fax: 412-624-1670
Education and Training
Education
BS, Mechanical Engineering, Lehigh University, 1990
MS, Mechanical Engineering, Lehigh University, 1992
PhD, Bioengineering, Carnegie Mellon University, 2000
Training
Post-Doctoral Fellowship - Pulmonary and Critical Care Medicine, University of Pittsburgh School of Medicine, 2002
Research Interest
Dr. Corcoran’s primary research interests include aerosol drug delivery and aerosol-based nuclear imaging of the lung. He has been extensively involved in the development of inhaled medications for lung transplant recipients and cystic fibrosis patients and the development special techniques for improving inhaled drug delivery such as the use of low density gases and surfactants to improve drug distribution in the lungs. Dr. Corcoran had developed imaging techniques for quantifying pulmonary physiology including measurements of mucociliary clearance and liquid absorption in the airways. These techniques have been tested in a series of clinical studies involving adult and pediatric patients and will be used to screen new medications for treating lung diseases such as cystic fibrosis. Dr. Corcoran has been the Principal Investigator on several NIH RO1 and UO1 awards as well as grants from the Cystic Fibrosis Foundation and the U.S. Army. He has previously directed research funded by the U.S. Army and the Cystic Fibrosis Foundation.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Corcoran TE, Saville A, Adams PS, Johnston DJ, Czachowski MR, Domnina YA, Li JH, Weiner DJ, Huber AS, Sanchez De Toledo J, Lo CW. Deposition Studies of Aerosol Delivery by Nasal Cannula to Infants. Pediatr Pulmonol. 2019; Aug;54(8): 1319-1325.
Serrano-Castillo F, Bertrand CA, Myerburg MM, Shapiro ME, Corcoran TE, Parker RS. A Physiologically-Motivated Model of Cystic Fibrosis Liquid and Solute Transport Dynamics across Primary Human Nasal Epithelia. J Pharmacokinet Pharmacodyn. 2019; PMID: 31494805.
Corcoran TE, Huber AS, Myerburg MM, Weiner DJ, Locke LW, Lacy RT, Weber L, Czachowski MR, Johnston DJ, Muthukrishnan A, Lennox AT, Pilewski JM. Multi-probe nuclear imaging of the cystic fibrosis lung as a biomarker of therapeutic effect. J Aerosol Med Pulm Drug Deliv. 2019; Apr 10.
Donaldson SH, Laube BL, Corcoran TE, Bhambhvani P, Zeman K, Ceppe A, Zeitlin PL, Mogayzel PJ Jr, Boyle M, Locke LW, Myerburg MM, Pilewski JM, Flanagan B, Rowe SM, Bennett WD. Effect of ivacaftor on mucociliary clearance and clinical outcomes in cystic fibrosis patients with G551D-CFTR. JCI Insight. 2018; Dec 20;3(24).
Locke LW, Myerburg MM, Weiner DJ, Markovetz MR, Parker RS, Muthukrishnan A, Weber L, Czachowski MR, Lacy RT, Pilewski JM, Corcoran TE. Pseudomonas infection and mucociliary and absorptive clearance in the cystic fibrosis lung. Eur Resp J. 2016; 47(5): 1392-401.
Stetten AZ, Moraca G, Corcoran TE, Tristam-Nagle S, Garoff S, Przybycien TM, Tilton RD. Enabling Marangoni flow at air-liquid interfaces through deposition of aerosolized lipid dispersions. J Colloid Interface Sci. 2016; 484: 270-278.
Locke, LW, Myerburg, MM, Markovetz, MR, Parker, RS, Weber, L, Czachowski, MR, Harding, TJ, Brown, SL, Nero, JA, Pilewski, JM, Corcoran, TE. Quantitative Imaging of Airway Liquid Absorption in Cystic Fibrosis. Eur Resp J. 2014; 44(3): 675-84.
Iacono AT, Johnson BA, Grgurich WF, Youssef JG, Corcoran TE, Seiler DA, Dauber JH, Smaldon GC, Zeevi A, Yousem SA, Fung JJ, Burckart GJ, McCurry KR, Griffith BP. A Randomized Trial of Inhaled Cyclosporine in Lung Transplant Recipients. N Engl J Med. 2006; 354: 141-150.
Sponsored Research/Activities
Title: Assessment of the AeroEclipse Breath Actuated Nebulizer (BAN) Compared to a Standard Jet Nebulizer in Normal Adult Subjects and when used with the Aerobika Oscillating Positive Expiratory Pressure Device
Role: Principal Investigator
Funding Agency: Trudell Medical International
Start Year: 2017
End Year: 2018
Title: Building Multilevel Models of Therapeutic Response in the Lungs
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: U01 HL131046
Start Year: 2016
End Year: 2020
Title: Imaging Airway Liquid Absorption in Cystic Fibrosis
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL108929
Start Year: 2011
End Year: 2017
Title: Peak Cough Flow and Airway Clearance in Pediatric Neuromuscular Disease
Role: Co-Principal Investigator
Funding Agency: RespirTech Technologies
Start Year: 2013
End Year: 2016
Title: Th2 Inflammation Promotes Airway Surface Liquid Dehydration
Role: Co-Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL112863
Start Year: 2012
End Year: 2017
Title: Improving Inhaled Drug Delivery with Self-Dispersing Surfactant Films
Role: Co-Principal Investigator
Funding Agency: Carnegie-Mellon University/National Heart, Lung, & Blood Institute
Grant Number: R01 HL105470
Start Year: 2011
End Year: 2016
Title: Respiratory Ciliary Dysfunction and Pulmonary Risks in Congenital Heart Disease Patients
Role: Co-Investigator
Funding Agency: Department of Defense
Start Year: 2015
End Year: 2018
Title: A Phase 2, Randomized, Double-Blind, Placebo Controlled, Parallel-Group, Exploratory Study to Evaluate Effects of VX-661 in Combination with Ivacaftro on Lung and Extrapulmonary Systems in Subjects Aged 18 Years and
Role: Co-Investigator
Funding Agency: Vertex
Start Year: 2015
End Year: 2018
Title: ACTIVATE-CF: Effects of a 6 Month Partially Supervised Conditioning Program In CF: An International Multi-Center Randomized Controlled
Role: Co-Investigator
Funding Agency: Cystic Fibrosis Foundation
Start Year: 2014
End Year: 2016
Title: Red Cell Transfusion: Modifier of Lung and Systemic Inflammatory Responses
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL086844
Start Year: 2013
End Year: 2018
Title: Understanding Protective Immunoregulatory Mechanisms in the Infant Lung
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R01 AI100012
Start Year: 2012
End Year: 2017
Title: Basic and Translational Studies of Cystic Fibrosis - Core B
Role: Associate Director
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: P30 DK072506
Start Year: 2015
End Year: 2018
Title: A Two-Part Multicenter Prospective Longitudinal Study of CFTR-Dependent Disease Profiling in Dystic Fibrosis (PROSPECT)
Role: Research Assistant
Funding Agency: Seattle Childrens Hospital/Cystic Fibrosis Foundation
Start Year: 2014
End Year: 2016
Notable Achievements
Pitt Greek Hall of Fame, 2016
Pitt Innovation Challenge Competition winner, 2014
Cathedral Award, Student Group Advising, University of Pittsburgh, 2013
Cathedral Award, Student Group Advising, University of Pittsburgh, 2009
Pitt Innovator Award, 2008
Young Investigator Award, International Society for Aerosols in Medicine, 2007