Department of Medicine
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Division of Pulmonary, Allergy and Critical Care Medicine
Faculty Profiles
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Alyssa D. Gregory, PhD
Research Assistant Professor of Medicine
Email:
adg56@pitt.edu
Phone: 412-802-5543
Contact
Office:
Starzl Biomedical Science Tower, W1200
200 Lothrop Street
Pittsburgh, PA 15213
Phone:
412-802-5543
Fax:
412-624-8960
E-mail:
adg56@pitt.edu
Administrative Assistant:
Judy Nauman
Email:
naumanja@upmc.edu
Phone:
412-864-3199
Fax:
412-692-2260
Education and Training
Education
BA, Biology, Washington University in St. Louis, 2003
PhD, Immunology, Washington University in St. Louis, 2009
Training
Post-doctoral, PACCM, University of Pittsburgh, 2012
Research Interest
Our group studies the contribution of neutrophils to the development to cigarette smoke-induced diseases (COPD/emphysema, lung cancer), with an emphasis on understanding the complex roles of neutrophil-derived serine proteinases. Our group was the first to describe the ability of a secreted proteinase, neutrophil elastase (NE), to gain entry into lung structural cells and to cleave an array of intracellular substrates. This finding unveils an additional level of regulation beyond the classical matrix-degrading functions of this and other proteinases. Additionally, our group studies the changes in innate immunity that occur with advanced age, which may play causative or contributory roles in pulmonary diseases which exhibit late-life onset. We are actively investigating stress granulopoiesis and changes to the bone marrow compartment which occur during chronic lung diseases and also with advanced age.
Publications
For my complete bibliography,
Click Here
.
Selected Publications:
Gregory, A.D., Kliment, C.R., Metz, H.E., Kim, K, Kargl, J, Agostini, B.A., Crum, L.T., Oczypok, E.A., Oury, T.A., Houghton, A.M. Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis.
Journal of Leukocyte Biology
. 2015; 98(2): 143-152.
Zhao, Y., Olonisakin, T., Xiong, Z., Hulver, M., Sayeed, S., Gregory, A.D., Kochman, E.J., Chen, B., Sun, M., Silverstein, R., Stolz, D.B., Shapiro S.D., Ray, A., Ray, P., Lee, J.S. Thrombospondin-1 regulates neutrophil microbial killing by restraining granule serine proteases during K. pneumoniae infection.
Mucosal Immunology
. 2015; 8(4): 896-905.
Gregory, A.D., Hale, P., Perlmutter, D.H., Houghton, A.M. Clathrin pit-mediated endocytosis of neutrophil elastase and cathepsin G by cancer cells.
Journal of Biological Chemistry
. 2012; 287(42): 35341-50.
Gregory, A.D., Houghton, A.M. Tumor-associated neutrophils: new targets for cancer therapy (Review).
Cancer Research
. 2011; 71(7): 2411-6.
Gregory, A.D., Capoccia, B.J., Woloszynek, J.R., Link, D.C. Systemic levels of G-CSF and interleukin-6 determine the angiogenic potential of bone marrow resident monocytes.
Journal of Leukocyte Biology
. 2010; 88(1): 123-31.
Houghton, A.M., Rzymkiewicz, D.M., Ji, H., Gregory, A.D., Egea, E.E., Metz, H.E., Stolz, D.B., Land, S.R., Marconcini, L.A., Kliment, C.R., Jenkins, K.M., Beaulieu, K.A., Mouded, M., Frank, S.J., Wong, K.K., Shapiro, S.D. Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth.
Nature Medicine
. 2010; 16(2): 219-23.
Capoccia, B.J., Gregory, A.D., Link, D.C. Recruitment of the inflammatory subset of monocytes to sites of ischemia induces angiogenesis in a monocyte chemoattractant protein-1 dependent fashion.
Journal of Leukocyte Biology
. 2008; 84(3): 760-8.
Rawls, A.S., Gregory, A.D., Woloszynek, J.R., Liu, F., Link, D.C. Lentiviral-mediated RNAi inhibition of SBDS in murine hematopoietic progenitors impairs their hematopoietic potential.
Blood
. 2007; 110(7): 2414-22.
Gregory, A.D., Hogue, L.A., Ferkol, T.W., Link, D.C. Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection.
Blood
. 2007; 109(8): 3235-43.
Semerad, C.L., Liu, F., Gregory, A.D., Stumpf, K., Link, D.C. G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood.
Immunity
. 2002; 17(4): 413-23.
Sponsored Research/Activities
Title:
Neutrophil Elastase and Aging
Role:
Principal Investigator
Funding Agency:
Aging Institute of UPMC
Start Year:
2018
End Year:
2019
Title:
Neutrophil Regulation of Insulin/IG-Mediated Cellular Senescence in COPD
Role:
Principal Investigator
Funding Agency:
Flight Attendants Medical Research Institute
Start Year:
2015
End Year:
2017
Title:
Vascular Subphenotypes of Lung Disease - Project 1
Role:
Co-Investigator
Funding Agency:
National Heart, Lung, & Blood Institute
Grant Number:
P01 HL103455
Start Year:
2011
End Year:
2016
Notable Achievements
Young Clinical Scientist Award, Flight Attendant Medical Research Institute, 2016-present
Member, American Thoracic Society, 2013-present
University of Pittsburgh Lung Cancer SPORE Career Development Award,, 2013-2014
Senior Research Training Fellowship, American Lung Association, 2011-2013
Research Excellence Award, American Thoracic Society, Section on Thoracic Oncology, 2011
ASH Annual Meeting Travel Award, American Society of Hematology, 2008
ASH Annual Meeting Travel Award, American Society of Hematology, 2007
Siteman Cancer Center Undergraduate Fellowship, Washington University in St. Louis School of Medicine, 2002
Howard Hughes Medical Institute Undergraduate Research Fellowship, 2001
Moog Scholar for Natural Sciences, Washington University in St. Louis, 1999-2003
