Department of Medicine
Faculty Profiles by Division

Division of Pulmonary, Allergy and Critical Care Medicine

Faculty Profiles

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photo Georgios D Kitsios, MD, PhD

Assistant Professor of Medicine

Director, American Board of Internal Medicine (ABIM) Research Pathway, Internal Medicine Residency Program, UPMC

Email: kitsiosg@upmc.edu

Phone: 412-383-0127

Contact
Office: UPMC Montefiore Hospital, NW 628
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-383-0127
Fax: 412-624-8373
E-mail: kitsiosg@upmc.edu
Administrative Assistant:
Cindy Vinkovich
Address: E1140 Starzl BST 200 Lothrop Street
Pittsburgh, PA 15213
Email: cerconecm@upmc.edu
Phone: 412-648-7784
Fax: 412-624-8373
Education and Training
Education
MD, Aristotle University of Thessaloniki, Greece, 2003
PhD, Genetic Epidemiology, University of Thessaly, Greece, 2009
MSc, Clinical and Translational Science, Tufts University, 2010
Training
Residency, Internal Medicine, Lahey Clinic, 2014
Fellowship, Pulmonary and Critical Care Medicine, University of Pittsburgh Medical Center, 2017
Research Interest
My translational research focuses on the development of microbial DNA sequencing-based diagnostics for pneumonia and sepsis in the intensive care unit, to improve upon major deficiencies in sensitivity and timeliness of the current culture-dependent diagnostic paradigm. My work further examines the ability to define ARDS subphenotypes from lung microbiome profiles and host innate immune response to explain the clinical heterogeneity of the syndrome and allow for better targeting of interventions. I am also interested in the impact of the gut microbiome on critical illness outcomes and the use of microbial replacement therapies with fecal transplant for the eradication of multidrug-resistant organisms in chronically critically-ill patients.
Clinical Interest
My clinical focus is on delivery of evidence-based critical care medicine across diverse critically-ill populations. I attend medical intensive care units across the UPMC system and I am also involved in provision of inpatient pulmonary consultations at the main campus and through telemedicine services.
Educational Interest
Evidence-based critical care, ventilator physiology
Publications
For my complete bibliography, Click Here.
Selected Publications:
Kitsios GD, Yang L, Manatakis DV, Nouraie M, Evankovich J, Bain W, Dunlap DG, Shah F, Barbash IJ, Rapport SF, Zhang Y, DeSensi RS, Weathington NM, Chen BB, Ray P, Mallampalli RK, Benos PV, Lee JS, Morris A, McVerry BJ. ARDS subphenotypes beyond ARDS: prognostic enrichment in mechanically-ventilated patients with or at risk for ARDS. Crit Care Med. 2019; in Press.
Fair K, Dunlap DG, Fitch A, Bogdanovich T, Methe B, Morris A, McVerry BJ, Kitsios GD. Rectal Swabs in Critically Ill Patients Provide Discordant Representations of the Gut Microbiome Compared to Stool Samples. mSphere. 2019; In Press.
Dunlap DG, Marshall CW, Fitch A, Rapport SF, Cooper VS, McVerry BJ, Morris A, Kitsios GD. Improved Detection of Culprit Pathogens by Bacterial DNA Sequencing Affects Antibiotic Management Decisions in Severe Pneumonia. Am J Case Rep. 2018; Nov 26; 19: 1405-1409.
Kitsios, GD. Translating lung microbiome profiles into the next-generation gold-standard diagnostic gold-standard of pneumonia: a clinical investigator’s perspective. mSystems. 2018; 3(2): e00153-17.
Kitsios GD, Fitch A, Manatakis DV, Rapport SF, Li K, Qin S, Huwe J, Zhang Y, Doi Y, Evankovich J, Bain W, Lee JS, Methe B, Benos PV, Morris A, McVerry BJ. Respiratory Microbiome Profiling for Etiologic Diagnosis of Pneumonia in Mechanically Ventilated Patients. Front Microbiol. 2018; Jul 10; 9: 1413.
Kitsios, GD, Rojas, M, Kass, DJ, Fitch, A, Sembrat, JC, Qin, S, Veraldi, KL, Gibson, KF, Lindell, KO, Pilewski, JM, Methe, B, Li, K, McDyer, J, McVerry, BJ, Morris, A. The Microbiome in Lung Explants of Idiopathic Pulmonary Fibrosis (MiLEs-IPF): a case-control study in patients with end-stage fibrosis. Thorax. 2017; in press.
Kitsios, GD, Morowitz, MJ, Dickson, RP, Huffnagle, GB, McVerry, BJ, Morris, A. Dysbiosis in the ICU: microbiome science coming to the bedside. J Crit Care. 2017; 38: 84-91.
Kitsios, GD, Morris, A, McVerry, BJ. Antibiotic de-escalation: observational causal inference and culture-dependence. Intensive Care Medicine. 2016; 42(10): 1647-8.
Kitsios, GD, Dahabreh, IJ, Callahan, S, Paulus, JK, Campagna, AC, Dargin, JM. Can we trust propensity scores in critical care? A systematic comparison with randomized clinical trials. Crit Care Med. 2015; 43: 1870-9.
Kitsios, GD, Mascari, P, Ettunsi, R, Gray, AW. Can co-administration of albumin and loop diuretics improve diuretic response in patients with hypoalbuminemia? A systematic review and meta-analysis. J Crit Care. 2014; 29(2): 253-9.
Sponsored Research/Activities
Title: Microbiome-Based Diagnosis of Pneumonia in the Acute Respiratory Distress Syndrome
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: K23 HL139987
Start Year: 2018
End Year: 2022
Title: Rapid Etiologic Diagnosis of Severe Pneumonia with Plasma cfDNA Sequencing
Role: Principal Investigator
Funding Agency: Karius, Inc.
Start Year: 2018
End Year: 2021
Notable Achievements
Best Translational Research Poster Award, 16th Annual Research Day, Department of Medicine, University of Pittsburgh, 2018
Robert M. Rogers Outstanding Scholarly Achievement Award, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Medical Center, 2018
Karius Clinical Investigator Award for Applied Infectious Disease Genomics, Karius, Inc., 2018
NIH NHLBI K23 Career Development Award in Mentored Patient-Oriented Research, 2018
Center for Medicine and the Microbiome – award for pilot clinical trial of Fecal Microbiota Transplantation, 2017
Breathe Pennsylvania Lung Health Research Award, 2017
Best Translational Research Poster Award, 15th Annual Research Day, Department of Medicine, University of Pittsburgh, 2017
ATS Abstract Scholarship, ATS International Conference, Washington DC 2017, 2017
ATS Abstract Scholarship, ATS International Conference, San Francisco 2016, 2016
Fellow Teaching Award of the year, Department of Medicine, University of Pittsburgh, 2015