Department of Medicine
Faculty Profiles by Division

Division of Pulmonary, Allergy and Critical Care Medicine

Faculty Profiles

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photo Janet So-Jung Lee, MD

Pulmonary, Allergy and Critical Care Medicine

Professor of Medicine

Director, Acute Lung Injury Center of Excellence

UPMC Chair in Acute Lung Injury

Member, Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute

Email: leejs3@upmc.edu

Phone: 412-692-2211

Contact
Office: UPMC Montefiore Hospital, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-692-2211
Fax: 412-692-2260
E-mail: leejs3@upmc.edu
Administrative Assistant:
Shannon McKenzie
Email: mckenziesj@upmc.edu
Phone: 412-692-2211
Fax: 412-692-2260
Education and Training
Education
BA, The Johns Hopkins University, 1991
MD, Georgetown University, 1995
Medicine Internship, University of Alabama at Birmingham, 1996
Medicine Residency, University of Alabama at Birmingham, 1998
Training
Pulmonary & Critical Care Fellowship, University of Washington, 2001
Post Doctoral Fellowship, University of Washington, 2004
Research Interest
Broadly speaking, our laboratory studies pulmonary host defense and molecular pathogenesis of acute lung injury. Our research focuses upon the innate arm of immunity, specifically examining effector function of myeloid cells such as macrophages and neutrophils and how they recognize and respond to exogenous pathogen associated molecular patterns or endogenous alarmins. We are interested in probing host-pathogen interactions to examine mechanisms of host protection following pathogen-triggered injury from products of extracellular gram-negative pathogens such as Pseudomonas aeruginosa and Klebsiella pneumoniae. We are also interested in the factors that shape repair and resolution following injury, specifically factors derived from hematopoietic cells such as platelets and red blood cells that can influence the course of inflammation. We utilize a repertoire of relevant murine models of injury, molecular genetic approaches, in vitro biochemical assays, and human bio-samples to examine innate host defenses of the lung.
Clinical Interest
Dr. Lee’s clinical interest and focus is acute lung injury, acute and chronic respiratory failure, transfusion consequences in the critically ill, sepsis-related immunosuppression, and other critical illness syndromes. Her clinical service is focused in the Medical Intensive Care Unit and the Advanced Lung Disease Service of the University Hospital. Dr. Lee is Director of the Acute Lung Injury Center of Excellence.
Educational Interest
Dr. Lee is actively involved in research training and teaching of medical students, graduate students, residents and fellows in Pulmonary and Critical Care Medicine. Her educational interest primarily focuses on training the next generation of physician-scientists and scientists interested in innate immunity, inflammation, cellular and molecular pathology of the lung.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Bain W, Olonisakin T, Yu M, Qu Y, Hulver M, Xiong Z, Li H, Pilewski J, Mallampalli R, Ray A, Ray P, Cheng Z, Shanks R, Alexander W, St. Croix C, Silverstein R, Lee JS. Platelets inhibit apoptotic lung epithelial cell death and protect mice against infection-induced lung injury. Blood Adv. 2019; Feb 12;3(3): 432-445.
Dar HH, Tyurina Y, Mikulska-Raminska K, Shrivastava I, Tyurin V, Krieger J, St. Croix C, Watkins S, Bayir E, Flitter R, Freedman C, Holman T, Pilewski J, Greenberger J, Mallampalli R, Doi Y, Lee JS, Bahar I, Bomberger J, Kagan V. Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium. J Clin Invest. 2018; Oct 1;128(10): 4639-4653.
Qu Y, Olonisakin T, Bain W, Zupetic J, Brown R, Hulver M, Xiong Z, Tejero J, Shanks RMQ, Bomberger JM, Cooper VS, Zegans ME, Ryu H, Han J, Pilewski J, Ray A, Cheng Z, Ray P, Lee JS. Thrombospondin-1 protects against pathogen-induced lung injury by limiting extracellular matrix proteolysis. JCI Insight. 2018; Feb 8;3(3): PMID:29415890.
Chakraborty K, Raundhal M, Chen B, Morse C, Tyurina YY, Khare A, Oriss TB, Huff R, Lee JS, St. Croix CM, Watkins S, Mallampalli RK, Kagan V, Ray A, Ray P. The Mito-DAMP Cardiolipin Blocks IL-10 Production Causing Persistent Inflammation During Bacterial Pneumonia. Nature Communications. 2017; Jan 11;8: 13944.
Flitter BA, Hvorecny KL, Ono E, Eddens T, Yang J, Kwak DH, Bahl CD, Hampton T, Morisseau C, Hammock BD, Liu X, Lee JS, Kolls JK, Levy BD, Madden DR, Bomberger JM. Pseudomonas aeruginosa sabotages the generation of host pro-resolving lipid mediators. Proc Natl Acad Sci USA. 2016; Dec 15: Epubaheadofprint.
Olonisakin T, Li HH, Xiong Z, Kochman EJK, Yu MT, Qu Y, Hulver M, Kolls JK, St. Croiz C, Doi Y, Nguyen MH, Shanks RMQ, Mallampalli RK, Kagan VE, Ray A, Silverstein RL, Ray P, Lee JS. CD36 provides host protection against Klebsiella pneumoniae intrapulmonary infection by enhancing LPS responsiveness and macrophage phagocytosis. J Infectious Dis. 2016; Sep 28: Epubaheadofprint.
Chen K, Eddens T, Trevejo-Nunez G, Way EE, Elsegeiny W, Ricks DM, Garg AV, Erb CJ, Bo M, Wang T, Chen W, Lee JS, Gaffen SL, Kolls JK. Epithelial IL-17R signaling is required for mucosal chemokine gradients and pulmonary host defense against K. pneumoniae. Cell Host & Microbe. 2016; Nov 9;20(5): 596-605.
Zhao Y, Olonisakin TF, Xiong Z, Hulver M, Sayeed S, Yu MT, Gregory AD, Kochman EJ, Chen BB, Mallampalli RK, Sun M, Silverstein RL, Stolz DB, Shapiro SD, Ray A, Ray P, Lee JS. Thrombospondin-1 regulates neutrophil microbial killing by restraining granule serine proteases during K. pneumoniae infection. Mucosal Immunol. 2015; Jul;8(4): 896-905.
Zhao Y, Xiong Z, Lechner EJ, Chan Y, Zhang Y, Ross MA, Stolz DB, Rosengart MR, Pilewski J, Ray P, Ray A, Silverstein RL, Lee JS. Thrombospondin-1 triggers macrophage IL-10 production and promotes resolution of experimental lung injury. Mucosal Immunol. 2014; March;7(2): 440-8.
Mangalmurti NS, Xiong Z, Hulver M, Ranganathan M, Liu XH, Oriss T, Rubin M, Triulzi D, Choi A, Lee JS. Loss of Red cell Chemokine Scavenging Promotes Transfusion Related Lung Inflammation. Blood. 2009; January 29; 113(5): 1158-66.
Sponsored Research/Activities
Title: Pittsburgh Innovation in Collaborative Training of Residents Alliance
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R38 HL150207
Start Year: 2020
End Year: 2024
Title: Evaluation of alternative complement activity within an ARDS cohort
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute / National Heart, Lung, & Blood Institute
Grant Number: R21 HL148088
Start Year: 2020
End Year: 2022
Title: Immunosuppression in Acute Lung Injury - Proj 4
Role: Principal Investigator
Funding Agency: Ohio State University/ National Institute of Health
Grant Number: P01 HL114453
Start Year: 2019
End Year: 2024
Title: The role of ACOD1 in immunomodulation in intrapulmonary Klebsiella pneumoniae infection
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL142084
Start Year: 2019
End Year: 2022
Title: Host Control Mechanisms Against K. Pneumoniae Infection in the Lungs
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL142084
Start Year: 2018
End Year: 2022
Title: Mechanisms of Host Protection Against Pathogen-Secreted Proteases in Acute Lung Injury
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL136143
Start Year: 2017
End Year: 2021
Title: Enhancing Neutrophil Responses to Counter MDR Gram Negative Bacterial Pneumonia
Role: Principal Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R21 AI119042
Start Year: 2015
End Year: 2017
Title: Red Cell Transfusion: Modifier of Lung and Systemic Inflammatory Responses
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL086844
Start Year: 2013
End Year: 2018
Title: Omics, Mice and Men: Development of Precision Transfusion Medicine
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL098032
Start Year: 2018
End Year: 2022
Title: Regulation of Neutrophilic Inflammation in Cystic Fibrosis
Role: Co-Investigator
Funding Agency: Cystic Fibrosis Foundation
Start Year: 2015
End Year: 2019
Title: Cardiolipin as a Novel Mediator of Acute Lung Injury - Project 3
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: P01 HL114453
Start Year: 2014
End Year: 2018
Title: Hemostasis and Vascular Biology Research Institute-Lee
Role: Co-Investigator
Funding Agency: Institute for Transfusion Medicine
Grant Number: RES
Start Year: 2013
End Year: 2028
Title: Storage Lesion in Banked Blood due to Disruption of Nitric Oxide Hemostasis
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL098032
Start Year: 2013
End Year: 2018
Notable Achievements
Member, American Thoracic Society Research Advocacy Committee, 2011-2016
Elected Member, American Society for Clinical Investigation, 2013
PACCM Outstanding Mentor Award, University of Pittsburgh, 2015
Vice Chair, Membership Committee, American Thoracic Society, 2015-2017
Member, American Thoracic Society Finance Committee, 2016
Chair, Membership Committee, American Thoracic Society, 2017-2019
AMA Women Physicians Section Inspirational Physicians Recognition Program Honoree, 2017
Elected Member, American Thoracic Society Allergy, Immunology, Inflammation Assembly Nomination Committee, 2019
Appointed Member, American Thoracic Society Scientific Advisory Committee, 2019
Elected Member, Association of American Physicians, 2020