Department of Medicine
Faculty Profiles by Division

Division of Pulmonary, Allergy and Critical Care Medicine

Faculty Profiles

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photo Adriana S. Leme, PhD

Pulmonary, Allergy and Critical Care Medicine

Research Associate Professor of Medicine

Email: asl15@pitt.edu

Phone: 412-864-3199

Contact
Office: Starzl Biomedical Science Tower
200 Lothrop Street, W1226-4B
Pittsburgh, PA 15213
 
Phone: 412-864-3199
Fax: 412-692-2260
E-mail: asl15@pitt.edu
Administrative Assistant:
Judy Nauman
Email: naumanja@upmc.edu
Phone: 412-864-3199
Fax: 412-692-2260
Education and Training
Education
BPharm, University of Sao Paulo, Brazil, 1991
MSc (Pharmacology), University of Sao Paulo, Brazil, 1995
PhD (Pathophysiology), University of Sao Paulo, Brazil, 2002
Training
Post-doctoral Research Fellow, Harvard T.H. Chan School of Public Health, 2005
Research Fellow, Brigham and Women’s Hospital, Harvard Medical School, 2006
Research Interest
Dr. Leme’s research interests have focused on the biological processes leading to emphysema/COPD development. She has acquired expertise in evaluating lung pathobiology and predisposition to COPD in mouse models using various approaches, including exposure to cigarette smoke.

Currently, Dr. Leme is interested in the innate immunity changes that occur with advanced age and their potential role in late-onset cancer. One particular aspect she is studying using different mouse models is how changes in mouse granulocyte-monocyte progenitors (GMPs) and common myeloid progenitors (CMPs) may affect the primary tumor progression and the development of metastases in aging mice.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Radder JE, Gregory AD, Leme AS, Cho MH, Chu Y, Kelly NJ, Bakke P, Gulsvik A, Litonjua AA, Sparrow D, Beaty TH, Crapo JD, Silverman EK, Zhang Y, Berndt A, Shapiro SA. Variable susceptibility to cigarette smoke-induced emphysema in 34 inbred strains of mice implicates Abi3bp in emphysema susceptibility. Am J Respir Cell Mol Biol. 2017; Sep;57(3): 367-375.
Dandachi N, Kelly NJ, Wood JP, Burton CL, Radder JE, Leme AS, Gregory AD, Shapiro SD. Macrophage Elastase Induces TRAIL-mediated tumor cell death through its carboxy-terminal domain. Am J Respir Crit Care Med. 2017; Aug 1;196(3): 353-363.
Kelly NJ, Radder JE, Baust JJ, Burton CL, Lai YC, Potoka KC, Agostini BA, Wood JP, Bachman TN, Vanderpool RR, Dandachi N, Leme AS, Gregory AD, Morris A, Moral AL, Gladwin MT, Shapiro SD. Mouse genome-wide association study of preclinical group II pulmonary hypertension identifies epidermal growth factor receptor. Am J Respir Cell Mol Biol. 2017; Apr;56(4): 488-496.
Tsuji T, Kelly NJ, Takahashi S, Leme AS, Houghton AM, Shapiro SD. Macrophage elastase suppresses white adipose tissue expansion with cigarette smoking. Am J Respir Cell Mol Biol. 2014; Dec;51(6): 822-9.
Xiong Z, Leme AS, Ray P, Shapiro SD, Lee JS. CX3CR1+ lung mononuclear phagocytes spatially confined to the interstitium produce TNF-alpha and IL-6 and promote cigarette smoke-induced emphysema. J Immunol. 2011; Mar 1;186(5): 3206-14.
Leme AS, Berndt A, Williams LK, Tsaih S-W, Szatkiewicz JP, Verdugo R, Paigen B, Shapiro SD. A survey of airway responsiveness in 36 inbred mouse strains facilitates gene mapping studies and identification of quantitative trait loci. Mol Genet Genomics. 2010; Apr;283: 317-26.
Fedulov AV, Leme A, Yang Z, Dahl M, Lim R, Mariani TJ, Kobzik L. Pulmonary exposure to particles during pregnancy causes increased neonatal asthma susceptibility. Am J Respir Cell Mol Biol. 2008; Jan;38(1): 57-67.
Leme AS, Hubeau C, Xiang Y, Goldman A, Hamada K, Suzaki Y, Kobzik L. Role of the breast milk in a mouse model of maternal transmission of asthma susceptibility. J Immunol. 2006; Jan 15;176(2): 762-9.
Leme AS, Lichtenstein A, Arantes-Costa FM, Landucci ECT, Martins MA. Acute lung injury in experimental pancreatitis in rats: pulmonary protective effects of crotapotin and N-acetylcysteine. Shock. 2002; Nov;18(5): 428-33.
Leme AS, Arantes FM, Maldonado EA, Warth MPTN, Martins MA. Capsaicin-induced release of vasoactive intestinal peptide-like immunoreactivity: modulation by enzyme inhibitors. Am J Physiol. 1996; Oct;271(4 Pt 1): L506-11.