Department of Medicine
Faculty Profiles by Division

Division of Pulmonary, Allergy and Critical Care Medicine

Faculty Profiles

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Brian F. Niemeyer, PhD

Pulmonary, Allergy and Critical Care Medicine

Research Instructor in Medicine

Email: niemeyerbf@upmc.edu

Phone: 412-624-7225

Contact
Office: UPMC Montefiore Hospital, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-624-7225
Fax: 412-624-1670
E-mail: niemeyerbf@upmc.edu
Administrative Assistant:
Stacie Truszkowski
Email: truszkowskisl@upmc.edu
Phone: 412-624-7225
Fax: 412-624-1670
Education and Training
Education
PhD, University of Colorado Anschutz Medical Campus; Immunology, 2017
BA, University of Colorado at Boulder; Molecular, Cellular and Developmental Biology, 2010
Training
Post-doctoral Fellow; Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 2020
Doctoral Candidate; Immunology Graduate Program, University of Colorado Anschutz Medical Campus, 2017
Research Interest
The focus of my research is to understand the complex interplay between respiratory infections and the innate immune response. To model this lung/bone marrow axis I combine multiple 3D organ-on-chip technologies including a novel human bone marrow-on-a-chip along with an established small airway-on-a-chip. Using these platforms I study how emerging and reemerging influenza and coronavirus strains can lead to disparate innate immune responses and interrogate potential therapeutic interventions.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Niemeyer BF, Miller CM, Ledesma-Feliciano C, Morrison JH, Jimenez-Valdes R, Clifton C, Poeschla EM, Benam KH. Broad antiviral and anti-inflammatory efficacy of nafamostat against SARS-CoV-2 and seasonal coronaviruses in primary bronchiolar epithelia. Nano Select. 2021; 00,1: https://doi.org/10.1002/nano.202100123.
Niemeyer BF, Kaiser AJ, Benam KH. Respiratory pathophysiology microphysiological models of human lung. Biomimetic Microengineering. 2020.
Jimenez-Valdes RJ, Can UI, Niemeyer BF, Ben. Where We Stand: Lung Organotypic Living Systems That Emulate Human-RelevantHost–Environment/Pathogen Interactions. Front. Bioeng. Biotechnol. 2020; 8:989: doi:10.3389/fbioe.2020.00989.
Logue JL, Solomon J, Niemeyer BF, Benam KH, Lin AE, Bjornson Z, Jiang S, McIlwain DR, Nolan GP, Palacios G, Kuhn JH. Innovative Technologies for Advancement of WHO Risk Group 4 Pathogens Research. Shapshak P. et al. (eds) Global Virology III: Virology in the 21st Century. 2019; Springer, Cham: https://doi.org/10.1007/978-3-030-29022-1_15.
Niemeyer BF, Zhao P, Tuder RM, Benam KH. Advanced Microengineered Lung Models for Translational Drug Discovery. SLAS DISCOVERY: Advancing the Science of Drug Discovery. 2018; 23(8): 777-789.
Niemeyer BF, Oko LM, Medina EM, Oldenburg DG, White DW, Cool CD, Clambey ET, van Dyk LF. Host tumor suppressor p18INK4c functions as a potent cell-intrinsic inhibitor of murine gammaherpesvirus 68 reactivation and pathogenesis. J Virol. 2018; 92:e01604-17: https://doi.org/10.1128/JVI.01604-17.