Department of Medicine
Faculty Profiles by Division

Division of Pulmonary, Allergy and Critical Care Medicine

Faculty Profiles

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photo Toru Nyunoya, MD

Associate Professor of Medicine


Phone: 412-624-7280

Office: UPMC Montefiore Hospital, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
Phone: 412-624-7280
Fax: 412-624-1670
Administrative Assistant:
Jackie Harden
Phone: 412-624-7441
Fax: 412-624-1670
Education and Training
MD, University of Tokushima School of Medicine, 1991
Internship, Internal Medicine, University of Hawaii affiliated Hospitals, Honolulu, 1999
Residency, Internal Medicine, University of Hawaii affiliated Hospitals, Honolulu, 2001
Fellowship, Pulmonary and Critical Care, University of Iowa Hospitals and Clinics, 2004
Research Interest
Dr. Nyunoya’s research interests include the potential role of DNA repair in the development of Chronic Obstructive Pulmonary Disease (COPD) and novel modulators for smoking-induced COPD. He has an interest in identifying a natural product to protect against cigarette smoke-induced DNA damage and cytotoxicity
For my complete bibliography, Click Here.
Selected Publications:
Bruse, S., Moreau, M., Bromberg, Y., Jang, J.H., Wang, N., Ha, H., Picchi, M., Lin, Y., Langley, R.J., Qualls, C., Klensney-Tait, J., Zabner, J., Leng, S., Mao, J., Belinsky, S.A., Xing, J., Nyunoya, T. Whole exome sequencing identifies novel candidate genes that modify chronic obstructive pulmonary disease susceptibility. Human Genomics. 2016; 10: 1.
Jang, J.H., Bruse, S., Liu, Y., Duffy, V., Zhang, C., Oyamada, N., Randell, S., Matsumoto, A., Thompson, D.C., Lin, Y., Vasiliou, V., Tesfaigzi, Y., Nyunoya, T. Aldehyde dehydrogenase 3A1 protects airway epithelial cells from cigarette smoke-induced DNA damage and cytotoxicity. Free Radical Biology Medicine. 2014; 68: 80.
Jang, J.H., Bruse, S., Huneidi, S., Schrader, R.M., Monick, M.M., Lin, Y., Carter, A.B., Klingelhutz, A.J., Nyunoya T. Acrolein-exposed normal human lung fibroblasts in vitro: cellular senescence, enhanced telomere erosion, and degradation of Werner's syndrome protein. Environmental Health Perspective. 2014; 122: 955.
Sponsored Research/Activities
Title: Molecular mechanisms underlying smoking-induced emphysema
Role: Principal Investigator
Funding Agency: American Heart Association
Start Year: 2019
End Year: 2022
Title: Network Management Core (NEMO) for the Pulmonary Trials Cooperative (PTC)(RETHINC)
Role: Principal Investigator
Funding Agency: COPD Foundation/ National Heart, Lung, & Blood Institute
Grant Number: U01 HL128954
Start Year: 2017
End Year: 2019