Department of Medicine
Faculty Profiles by Division

Division of Pulmonary, Allergy and Critical Care Medicine

Faculty Profiles

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photo Iulia D. Popescu, PhD

Pulmonary, Allergy and Critical Care Medicine

Research Associate Professor of Medicine

Flow Cytometry Core Manager


Phone: 412-624-8915

Office: Starzl Biomedical Science Tower, W1228
200 Lothrop Street
Pittsburgh, PA 15261
Phone: 412-624-8915
Administrative Assistant:
Patty Geraci
Address: UPMC Montefiore Hospital
3459 Fifth Avenue, NW628
Pittsburgh, PA 15213
Phone: 412-692-2118
Fax: 412-692-2260
Education and Training
BS, Biology-Chemistry, CA Rosetti School, Bucharest, Romania, 1985
MS-Chemistry Engineering, Polytechnic University, Bucharest, Romania, 1992
PhD, University of Bucharest Chemistry Dept, 2000
Postdoc Immunology, University of Pittsburgh Cancer Institute, 1997
Postdoc transplant, University of Pittsburgh Transplantation Institute, 2006
PhD Visiting Research Fellow-Immunology/Cancer, University of Pittsburgh, 1997
Postdoctoral Research Associate-Immunology/Transplant, University of Pittsburgh, 2006
Research Interest
Dr. Popescu has a solid academic background in immunology, cancer, virology and transplantation, and a keen interest in research and clinical trials. She has a great interest for immunology and translational science, as well for new drug discovery and technology. Also a keen interest in evaluating potential new targets in proof of concept studies, the pre-clinical/clinical stage of drug development and clinical biomarker research and development.
For my complete bibliography, Click Here.
Selected Publications:
Popescu, I, Pipeling, MR, Shah, PD, Orens, JB, McDyer, JF. T-bet:Eomes Balance, Effector Function and Proliferation of CMV-specific CD8+ T-cells during Primary Infection Differentiates the Capacity for Durable Immune Control. J Immunol. 2014; 193: 5709-5722.
Popescu, I, Drummond, MB, Gama, L, Merlo, CA, Astemborski, J, Brown, RH, Wise, RA, Clements, JE, Kirk, GD, McDyer, JF. Activation-Induced Cell Death Drives Profound Lung CD4+ T Cell Depletion in HIV-associated Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2014; Oct 1;190(7): 744-55.
Lendermon, EA, Dodd-o, JM, Coon, T, Miller, HL, Ganguly, S, Popescu, I, O'Donnell, C, Cardenes, N, Levine, M, Rojas, M, Weathington, NM, Zhao, Y, McDyer, JF. CD8+IL-17+ T Cells Mediate Neutrophilic Airway Obliteration in T-bet deficient Mouse Lung Allograft Recipients. Am J Respir Cell Mol Biol. 2014; Oct: 6.
Wiesmayr, S, Webber, SA, Macedo, C, Popescu, I, Smith, L, Luce, J, Metes, D. Decreased NKp46 and NKG2D and elevated PD-1 are associated with altered NK-cell function in pediatric transplant patients with PTLD. Eur J Immunol. 2011; Nov 22: doi:10.1002/eju.201141832.
Macedo, C, Webber, SA, Donnenberg, A, Popescu, I, Hua, Y, Green, M, Rowe, D, Smith, L, Brooks, M, Metes, D. EBV-specific CD8+ T cells from pediatric thoracic transplant patients carrying chronic high EBV loads display contrasting features: activated phenotype and exhausted function. Journal of Immunology. 2011; May 15; 186(10): 5854-62.
Macedo, C, Zeevi, A, Bentlejewski, C, Popescu, I, Green, M, Rowe, D, Smith, L, Webber, S, Metes, D. The impact of EBV load on T cell immunity in pediatric thoracic transplant recipients. Transplantation. 2009; Jul 15; 88(1): 123-8.
Macedo, C, Orkis, EA, Popescu, I, Elinoff, BD, Zeevi, A, Shapiro, R, Lakkis, FG, Metes, D. Contribution of naïve and memory T cell populations to the normal human alloimmune response. American Journal of Transplantation. 2009; Sep;9(9): 2057-66.
Sponsored Research/Activities
Title: COVID Convalescent Plasma Pittsburgh Program
Role: Co-Investigator
Funding Agency: Pittsburgh Foundation
Grant Number: RES MR2020
Start Year: 2020
End Year: 2021
Title: Molecular and Clinical Endotypes in Chronic Lung Allograft Dysfunction
Role: Co-Investigator
Funding Agency: Cystic Fibrosis Foundation
Start Year: 2017
End Year: 2019
Title: Cadaveric Donor Lung and Bone Marrow Transplantation in Immunodeficiency Diseases
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: U01 AI125050
Start Year: 2016
End Year: 2021
Title: Immune Mechanisms of HIV-associated COPD
Role: Research Assistant
Funding Agency: Johns Hopkins University
Grant Number: U01 HL121814
Start Year: 2013
End Year: 2018