Department of Medicine
Faculty Profiles by Division

Division of Pulmonary, Allergy and Critical Care Medicine

Faculty Profiles

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photo Raju C. Reddy, MD

Visiting Associate Professor of Medicine

Chief of Pulmonary Division, VA Pittsburgh Healthcare System

Email: reddyrc@upmc.edu

Phone: 412-624-7225

Contact
Office: UPMC Montefiore Hospital, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-624-7225
Fax: 412-624-1670
E-mail: reddyrc@upmc.edu
Administrative Assistant:
Pamela Constable
Email: Pamela.Constable@va.gov
Administrative Assistant:
Stacie Truszkowski
Email: struszkowski@upmc.edu
Phone: 412-624-7225
Fax: 412-624-1670
Education and Training
Education
BS, Chemistry, Mathematics, Vanderbilt University, 1991
MD, University of Tennessee, 1995
Training
Residency, Internal Medicine, University of Tennessee, 1998
Fellowship, Pulmonary and Critical Care Medicine, University of Michigan, 2001
Postdoctoral Research, National Institutes of Health, NHLBI, 2003
Research Interest
1. Orphan nuclear receptors
2. PPARs and orphan nuclear receptors in lung disease
3. PPAR ligand characterization
4. Pulmonary drug discovery
Publications
For my complete bibliography, Click Here.
Selected Publications:
Reddy, AT, Lakshmi, SP, Muchumarri, RR, Reddy, RC. Nitrated Fatty Acids Reverse Cigarette Smoke-Induced Alveolar Macrophage Activation and Inhibit Protease Activity via Electrophilic S-Alkylation. PLoS One. 2016; Apr 27;11(4): e0153336.
Lakshmi, SP, Reddy, AT, Zhang, Y, Sciurba, FC, Mallampalli, RK, Duncan, SR, Reddy, RC. Downregulated peroxisome proliferator-activated receptor ? (PPAR?) in lung epithelial cells promotes a PPAR? agonist-reversible proinflammatory phenotype in chronic obstructive pulmonary disease (COPD). J Biol Chem. 2014; 289: 6383-6393.
Reddy, AT, Lakshmi, SP, Dornadula, S, Pinni, S, Rampa, DR, Reddy, RC. The nitrated fatty acid 10-nitrooleate attenuates allergic airway disease. J Immunol. 2013; 191: 2053-2063.
Reddy, AT, Lakshmi, SP, Kleinhenz, JM, Sutliff, RL, Hart, CM, Reddy, RC. Endothelial cell peroxisome proliferator-activated receptor y reduces endotoxemic pulmonary inflammation and injury. J Immunol. 2012; 189: 5411-5420.
Narala, VR, Adapala, R, Brock, T, Peters-Golden, M, Reddy, RC. LTB4 is a physiologically relevant endogenous peroxisome proliferator-activated receptor-a agonist. J Biol Chem. 2010; 285: 22067-22074.
Lakshmi, SP, Reddy, AT, Naik, MU, Naik, UP, Reddy, RC. Effects of JAM-A deficiency or blocking antibodies on neutrophil migration and lung injury in a murine model of ALI. Am J Physiol Lung Cell Mol Physiol. 2012; 303: 758-766.
Milam, JE, Keshamouni, VG, Phan, SH, Hu, B, Hogaboam, CM, Standiford, TJ, Thannickal, VJ, Reddy, RC. PPAR-? agonists inhibit pro-fibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2008; 294: 891-901.
Reddy, RC, Srirangam, A, Reddy K, Chen, J, Gangireddy, S, Kalemkerian, G, Standiford, TJ, Keshamouni, VG. Chemotherapeutic drugs induce PPAR-? expression and show sequence-specific synergy with PPAR-? ligands in inhibition of non-small-cell lung cancer. Neoplasia. 2008; 10: 597-603.
Reddy, RC, Narala, VR, Keshamouni, VG, Milam, JE, Newstead, MW, Standiford, TJ. Sepsis-induced inhibition of neutrophil chemotaxis is mediated by activation of peroxisome proliferator-activated receptor-gamma. Blood. 2008; 112: 4250-4258.
Sponsored Research/Activities
Title: Airway epithelial Cell Farnesoid X Receptor in COPD Pathophysiology
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL137842
Start Year: 2017
End Year: 2021
Title: Peroxisome Proliferator-activated Receptor Delta as a Therapeutic Target in Smoke-exacerbated Rhinosinusitis
Role: Principal Investigator
Funding Agency: Flight Attendants Medical Research Institute
Start Year: 2017
End Year: 2020
Title: Novel Nrf2 Activators for Lung Disease
Role: Principal Investigator
Funding Agency: UPMC Enterprises
Grant Number: RES
Start Year: 2017
End Year: 2018
Title: PPAR-delta as a Novel Therapeuic Target in Asthma
Role: Principal Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R01 AI125338
Start Year: 2016
End Year: 2021
Title: Nitrated Fatty Acids, Novel Anti-inflammatory Mediators in Allergic Airway Disease
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL093196
Start Year: 2013
End Year: 2016