Department of Medicine
Faculty Profiles by Division

Division of Pulmonary, Allergy and Critical Care Medicine

Faculty Profiles

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photo Steven D. Shapiro, MD

Executive Vice President, UPMC

Chief Medical and Scientific Officer, UPMC

President, Health Services Division

Distinguished Professor of Medicine


Phone: 412-647-3395

Office: US Steel Tower, Suite 6250
600 Grant Street
Pittsburgh, PA 15219
Phone: 412-647-3395
Administrative Assistant:
Dawn Ambrose Allan
Phone: 412-647-3395
Education and Training
BA, University of Chicago, Chicago IL, 1978
MD, University of Chicago, Chicago IL, 1983
Internship, Washington University, St. Louis, Missouri, 1984
Residency, Washington University, St. Louis, Missouri, 1986
Fellowship Respiratory & Critical Care, Washington University, St. Louis, Missouri, 1989
Chief Resident and Assistant Program Dir, Washington University, St. Louis, Missouri, 1990
Research Interest
Dr. Shapiro’s laboratory focuses on the role of inflammatory cell derived proteinases in the progression of COPD/emphysema and lung cancer. He originally cloned and knocked-out macrophage elastase (MMP-12) to demonstrate that MMP-12 deficient mice are completely protected from the development of cigarette smoke-induced emphysema. Dr. Shapiro’s lab has continued to study the contribution of numerous inflammatory cell derived proteinases in emphysema and lung cancer progression using gene targeting in mice. More recently, his lab has begun to study the role of repair (or lack thereof) in the progression of emphysema by using lineage-tagging approaches to study putative stem cell populations residing within the lung.
For my complete bibliography, Click Here.
Selected Publications:
Dandachi, NG, Shapiro, SD. A protean protease: MMP-12 fights viruses as a protease and a transcription factor. Nat Med. 2014; May;20(5): 470-2.
Minematsu, N, Blumental-Perry, A, Shapiro, SD. Cigarette smoke inhibits engulfment of apoptotic cells by macrophages by inhibition of actin rearrangement. Am J Resp Cell Mol Biol. 2011; 44: 474-482.
Houghton, AM, Rymkiewicz, D, Ji, H, Gregory, A, Egea, E, Metz, H, Stolz, DB, Marconcini, LA, Jenkins, K, Beaulieu, K, Mouded, M, Frank, SJ, Wong, KK, Shapiro, SD. Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth. Nat med. 2010; 16: 219-223.
Hunninghake, GM, Cho, MH, Tesfaigzi, Y, Soto-Quiros, ME, Avila, L, Lasky-Su, J, Stidley, C, Melen, E, Soderhall, C, Hallberg, J, Kull, I, Kere, J, Svartengren, M, pershagen, G, Wickman, M, Lange, C, Demeo, DL, Hersh, CP, Shapiro, SD, all. MMP12, lung function, and COPD in high-risk populations. N Engl J Med. 2009; Dec 31;361(27): 2599-608.
Houghton, AM, Hartzell, WO, Robbins, CS, Gomis-Ruth, FX, Shapiro, SD. Macrophage Elastase(MMP-12) kills bacteria within murine macrophages. Nature. 2009; Jul 30;460(7225): 637-41.
Mouded, M, Egea, EE, Brown, MJ, Hanlon, SM, Houghton, AM, Tsai, LW, Ingenito, EP, Shapiro, SD. Epithelial cell apoptosis causes acute lung injury masquerading as emphysema. Am J Respir Cell Mol Biol. 2009; Oct;41(4): 407-14.
Maeno, T, Houghton, AM, Quintero, PA, Grumelli, S, Owen, CA, Shapiro, SD. CD8+ T cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice. J Immunol. 2007; 178: 8090-96.
Sponsored Research/Activities
Title: The Emphysematous Microenvironment Promotes Lung Tumorigenesis and Progression
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL107883
Start Year: 2011
End Year: 2017
Title: Novel F Box Anti-Inflammatories for COPD
Role: Co-Investigator
Funding Agency: Flight Attendants Medical Research Institute
Start Year: 2014
End Year: 2017
Title: Vascular Subphenotypes of Lung Disease - Project 1
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: P01 HL103455
Start Year: 2011
End Year: 2016