Department of Medicine
Faculty Profiles by Division

Division of Pulmonary, Allergy and Critical Care Medicine

Faculty Profiles

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photo Jesus Tejero, PhD

Assistant Professor of Medicine


Phone: 412-624-2651

Office: Starzl Biomedical Science Tower, E1228
200 Lothrop Street
Pittsburgh, PA 15261
Phone: 412-624-2651
Fax: 412-648-3046
Administrative Assistant:
Anna Marie Rompala
Phone: 412-648-2358
Fax: 412-648-5980
Education and Training
BS, Chemistry, University of Saragossa, Spain, 1998
PhD, Biochemistry, University of Saragossa, Spain, 2004
Research Interest
Dr. Tejero’s research is focused on the biology of heme proteins. His main research goals include: i) to understand and characterize the chemical and kinetic features of the reactions of nitrite with hemoglobin, myoglobin, cytoglobin and neuroglobin, ii) to elucidate the cytoprotective mechanisms of the six-coordinate globins neuroglobin and cytoglobin, and iii) the development of heme-based antidotes for carbon monoxide poisoning.
For my complete bibliography, Click Here.
Selected Publications:
Amdahl, MB, Sparacino-Watkins, CE, Corti, P, Gladwin, MT, Tejero, J. Efficient Reduction of Vertebrate Cytoglobins by the Cytochrome b5/Cytochrome b5 Reductase/NADH System. Biochemistry. 2017; 56(30): 3993-4004.
Azarov, I, Wang, L, Rose, JJ, Xu, Q, Huang, XN, Belanger, A, Wang, Y, Guo, L, Liu, C, Ucer, KB, McTiernan, CF, O'Donnell, CP, Shiva, S, Tejero, J, Kim-Shapiro, DB, Gladwin, MT. Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning. Science Translational Medicine. 2016; 8(368): 368ra173.
Corti, P, Xue, J, Tejero, J, Wajih, N, Sun, M, Stolz, DB, Tsang, M, Kim-Shapiro, DB, Gladwin, MT. Globin X is a six-coordinate globin that reduces nitrite to nitric oxide in fish red blood cells. Proc Natl Acad Sci USA. 2016; In Press.
Tejero, J, Kapralov, AA, Baumgartner, MP, Sparacino-Watkins, C, Anthonymuthu, TS, Vlasova, II, Camacho, CJ, Gladwin, MT, Bayir, H, Kagan, VE. Peroxidase Activation of Cytoglobin by Anionic phospholipids: Mechanisms and Consequences. BBA-Mol Cell Biol L. 2016; 1861: 391-401.
Corti, P, Ieraci, M, Tejero, J. Characterization of zebrafish neuroglobin and cytoglobins 1 and 2: Zebrafish cytoglobins provide insights into the transition from six-coordinate to five-coordinate globins. Nitric Oxide. 2016; 53: 22-34.
Tejero, J, Sparacino-Watkins, CE, Ragireddy, V, Frizzell, S, Gladwin, MT. Exploring the mechanisms of the reductase activity of neuroglobin by site-directed mutagenesis of the heme distal pocket. Biochemistry. 2015; 54: 722-733.
Sparacino-Watkins, CE, Tejero, J, Gauthier, MC, Ragireddy, V, Thomas, J, Azarov, I, Wang, J, Merchant, B, Basu, P, Gladwin, MT. Nitrite reductase and NO synthase activity of the mitochondrial molybdopterin enzymes mARC (MOSC) 1 and 2. J Biol Chem. 2014; 289: 10345-10358.
Tejero, J, Basu, S, Helms, C, Hogg, N, King, SB, Kim-Shapiro, DB, Gladwin, MT. Low NO concentration-dependence of the reductive nitrosylation reaction of haemoglobin. J Biol Chem. 2012; 287: 18262-18274.
Tiso, M, Tejero, J, Basu, S, Azarov, I, Wang, X, Simplaceanu, V, Frizzell, S, Jayaraman, T, Geary, L, Shapiro, C, Ho, C, Shiva, S, Kim-Shapiro, DB, Gladwin, MT. Human neuroglobin functions as a redox regulated nitrite reductase. J Biol Chem. 2011; 286: 18277-18289.
Tejero, J, Biswas, A, Wang, ZQ, Page, RC, Haque, MM, Hemann, C, Zwejer, JL, Misra, S, Stuehr, DJ. Stabilization and characterization of a heme-oxy reaction intermediate in inducible nitric-oxide synthase. J Biol Chem. 2008; 283: 33498-33507.
Sponsored Research/Activities
Title: CO Scavenging by Heme Containing Proteins - Studies of Kinetics, Stability, and Toxicity
Role: Principal Investigator
Funding Agency: Globin Solutions, Inc.
Grant Number: RES
Start Year: 2018
End Year: 2019
Title: Countermeasure Therapeutics for Acute Lung Injury
Role: Co-Principal Investigator
Funding Agency: National Institute of Environmental Health Sciences
Grant Number: R21 ES027390
Start Year: 2016
End Year: 2018
Title: Therapeutic Targeting of Vascular Subphenotypes of Lung Disease
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: P01 HL103455
Start Year: 2016
End Year: 2021
Title: Role of Erythroid DAMP Molecules in the Pathogenesis of Vascular Injury in Sepsis
Role: Co-Investigator
Funding Agency: National Institute of General Medical Science
Grant Number: R01 GM113816
Start Year: 2015
End Year: 2019
Title: Antidote for Inhaled CO Poisoning Based on Mutationally Engineered Neuroglobin
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL125886
Start Year: 2014
End Year: 2018
Title: Vascular Subphenotypes of Lung Disease - Project 3
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: P01 HL103455
Start Year: 2011
End Year: 2016