Department of Medicine
Faculty Profiles by Division

Division of Pulmonary, Allergy and Critical Care Medicine

Faculty Profiles

[Return To Index page]
photo Eleanor B. Valenzi, MD

Pulmonary, Allergy and Critical Care Medicine

Assistant Professor of Medicine


Phone: 412-648-6494

Office: UPMC Montefiore, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
Phone: 412-648-6494
Fax: 412-692-2260
Administrative Assistant:
Gabrielle Amity
Phone: 412-648-6494
Fax: 412-648-6495
Education and Training
BA - Biology, University of Pennsylvania, Philadelphia, PA, 2009
MD, University of Alabama School of Medicine, 2013
Internship, Internal Medicine, University of Chicago, 2014
Resident, Internal Medicine, University of Chicago, 2016
Fellow, Pulmonary and Critical Care Medicine, University of Pittsburgh School of Medicine, 2019
Research Interest
Dr. Valenzi's research involves translational investigations into the underlying pathobiology of interstitial lung disease, with a focus on systemic sclerosis-associated interstital lung disease (SSc-ILD). She utilizes high-throughput single-cell sequencing technologies to investigate fibroblast heterogeneity and transformation in SSc-ILD and other interstitial lung diseases.

Dr. Valenzi also participates in clinical trials for new treatments of idiopathic pulmonary fibrosis and other interstitial lung diseases.
Clinical Interest
Dr. Valenzi's clinical interests lie in the care of patients with interstitial lung disease. She has an outpatient clinic in the Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, where she collaborates closesly with rheumatologists, radiologists, pathologists, and other pulmonologists in the multidisciplinary care of patients with complex disease. Dr. Valenzi also attends on the Medical Intensive Care Unit, Advanced Lung Disease, and Pulmonary Consultation services.
Educational Interest
Dr. Valenzi teaches pulmonary physiology to medical students at the University of Pittsburgh School of Medicine. She also teaches interstitial lung disease, pulmonary medicine, and evidence-based critical care medicine to resdients and fellows during rotations at UPMC Presbyterian and UPMC East.
For my complete bibliography, Click Here.
Selected Publications:
Valenzi E, Bulik M, Tabib T, Morse C, Sembrat J, Trejo Bittar H, Rojas M, Lafyatis R. Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease. Ann Rheum Dis. 2019; Oct;78(10): 1379-1387.
Valenzi E, Kass DJ. Diagnosis from Afar: Is Remote Multidisciplinary Discussion Appropriate for Interstitial Lung Disease Care?. Ann Am Thorac Soc. 2019; Apr;16(4): 434-436.
Morse C, Tabib T, Sembrat J, Buschur KL, Bittar HT, Valenzi E, Jiang Y, Kass DJ, Gibson K, Chen W, Mora A, Benos PV, Rojas M, Lafyatis R. Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis. Eur Respir J. 2019; Aug;54(2): doi:10.1183/13993003.02441-2018.
Saygin D, Tabib T, Bittar HET, Valenzi E, Sembrat J, Chan SY, Rojas M, Lafyatis R. Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension. Pulm Circ. 2020; Jan-Mar;10(1): eCollection2020Jan-Mar.
Lear TB, McKelvey AC, Evankovich JW, Rajbhandari S, Coon TA, Dunn SR, Londino JD, McVerry BJ, Zhang Y, Valenzi E, Burton CL, Gordon R, Gingras S, Lockwood KC, Jurczak MJ, Lafyatis R, Shlomchik MJ, Liu Y, Chen BB. KIAA0317 regulates pulmonary inflammation through SOCS2 degradation. JCI Insight. 2019; Oct 3;4(19): doi:10.1172/jci.insight.129110.
Lear TB, Lockwood KC, Larsen M, Tuncer F, Kennerdell JR, Morse C, Valenzi E, Tabib T, Jurczak MJ, Kass DJ, Evankovich JW, Finkel T, Lafyatis R, Liu Y, Chen BB. Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosis. J Biol Chem. 2020; Mar 27;295(13): 4171-4180.
Sponsored Research/Activities
Title: Transcriptional and epigenetic investigation of the master regulator of myofibroblast transformation in systemic sclero
Role: Principal Investigator
Funding Agency: Scleroderma Foundation
Start Year: 2020
End Year: 2023
Notable Achievements
Robert M. Rogers Award for Outstanding Scholars Achievement, 2020
Scleroderma Foundation New Investigator Grant, 2020
American Thoracic Society Abstract Scholarship Award, 2019
American Thoracic Society Public Advisory Roundtable Abstract Award, 2019
15th Annual Respiratory Disease Young Investigators' Forum, 2019
American Thoracic Society Abstract Scholarship Award, 2018
Pittsburgh International Lung Conference Outstanding Scientific Research Award, 2018
American Thoracic Society Abstract Scholarship Award, 2015