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Division of Pulmonary, Allergy and Critical Care Medicine
Faculty Profiles
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Ling Wang, MD, PhD
Research Assistant Professor of Medicine
Email:
lingwang@pitt.edu
Phone: 412-648-3037
Contact
Office:
Starzl Biomedical Science Tower, E1200
200 Lothrop Street
Pittsburgh, PA 15261
Phone:
412-648-3037
Fax:
412-648-5980
E-mail:
lingwang@pitt.edu
Administrative Assistant:
Anna Marie Rompala
Email:
amr208@pitt.edu
Phone:
412-648-2358
Fax:
412-648-5980
Education and Training
Education
MD, Shanghai Medical School, Fudan University
PhD, Shanghai Medical School, Fudan University
Training
Postdoctoral Research Fellow, Pulmonary, Allergy & Critical Care Medicine, Vanderbilt University, Nashville,TN, 2008
Postdoctoral associate, Vascular Medicine Institute, University of Pittsburgh, 2010
Research Interest
Dr. Wang has two main areas of interest:
1) Nitrite and NO signaling pathway in vascular and cardiopulmonary diseases such as ALI, lung fibrosis, PAH and I/R injury. The purpose of this research is to investigate the downstream signaling pathways regulated by nitrite and NO in cellular and animal models in order to identify new therapeutic targets and develop nitrite-based therapy.
2) Mutant human Ngb as an antidote for carbon monoxide poisoning. This research aims to develop a specific antidote using mutationally engineered human Ngb as a "CO trap" which removes CO from blood, tissue and cells.
Publications
For my complete bibliography,
Click Here
.
Selected Publications:
Azarov, I, Wang, L (Co-first author), Rose, JJ, Xu, Q, Huang, N, Belanger, A, Ying, Wang, Lanping, Guo, Liu, C, Ucer, KB, McTiernan, CF, O’Donnell, C, Shiva, S, Tejero, J, Kim-Shapiro, D, Gladwin, MT. Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning.
Sci Transl Med
. 2016; Volume(Issue) : 8(368): 368.
Rose, JJ, Wang, L, Xu, Q, McTiernan, CF, Shiva, S, Tejero, J, Gladwin, MT. Carbon Monoxide Poisoning: Pathogenesis, Management and Future Directions of Therapy.
Am J Respir Crit Care Med, Oct 18
. 2016.
Rose JJ, Xu Q, Wang L, Gladwin MT. Shining a Light on Carbon Monoxide Poisoning.
American journal of respiratory and critical care medicine
. 2015; 192(10): 145-7.
Zhao X, Wang L, Shiva S, Tejero J, Wang J, Frizzell S, Gladwin MT. Mechanisms for cellular NO oxidation and nitrite formation in lung epithelial cells.
Free radical biology & medicine
. 2013; 61: 428-37.
Wang L, Frizzell SA, Zhao X, Gladwin MT. Normoxic cyclic GMP-independent oxidative signaling by nitrite enhances airway epithelial cell proliferation and wound healing.
Nitric Oxide
. 2012; 26(4): 203-10.
Wang L, Bastarache JA, Ware LB. The coagulation cascade in sepsis.
Current pharmaceutical design
. 2008; 14(19): 1860-9.
Wang L, Bastarache JA, Wickersham N, Fang X, Matthay MA, Ware LB. Novel role of the human alveolar epithelium in regulating intra- alveolar coagulation.
American journal of respiratory cell and molecular biology
. 2007; 36(4): 497-503.
Bastarache JA, Wang L, Geiser T, Wang Z, Albertine KH, Matthay MA, Ware LB. The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor.
Thorax
. 2007; 62(7): 608-16.
Wang L, Zhu DM, Su X, Bai CX, Ware LB, Matthay MA. Acute cardiopulmonary effects of a dual-endothelin receptor antagonist on oleic acid-induced pulmonary arterial hypertension in dogs.
Experimental lung research
. 2004; 30(1): 31-42.
Sponsored Research/Activities
Title:
CO Scavenging by Heme Containing Proteins - Studies of Kinetics, Stability, and Toxicity
Role:
Co-Investigator
Funding Agency:
Globin Solutions, Inc.
Grant Number:
RES
Start Year:
2018
End Year:
2019
Title:
Antidote for Inhaled CO Poisoning Based on Mutationally Engineered Neuroglobin
Role:
Co-Investigator
Funding Agency:
National Heart, Lung, & Blood Institute
Grant Number:
R01 HL125886
Start Year:
2014
End Year:
2018
Title:
Storage Lesion in Banked Blood Due to Disruption of Nitric Oxide Hemostasis
Role:
Co-Investigator
Funding Agency:
National Heart, Lung, & Blood Institute
Grant Number:
R01 HL098032
Start Year:
2013
End Year:
2018
