Department of Medicine
Faculty Profiles by Division

Division of Pulmonary, Allergy and Critical Care Medicine

Faculty Profiles

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photo Nathaniel M. Weathington, MD, PhD

Assistant Professor of Medicine


Phone: 412-624-8669

Office: UPMC Montefiore Hospital, NW 628
3459 Fifth Avenue
Pittsburgh, PA 15213
Phone: 412-624-8669
Fax: 412-383-7113
Administrative Assistant:
Mary Pat Rocco
Phone: 412-864-3838
Fax: 412-692-2888
Education and Training
BS, University of South Alabama, 1999
MD, University of Alabama School of Medicine, 2007
PhD, Cellular & Molecular Physiology, University of Alabama at Birmingham, 2007
Residency, Internal Medicine, University of Alabama Birmingham Department of Medicine, 2010
Fellowship, Pulmonary and Critical Care, University of Pittsburgh School of Medicine, 2011
Research Interest
My research interests are diverse. One area of interest is the regulation of cytokine receptors in the lung and the impact of that regulation on immunity. Closely related immunoreceptors (e.g. IL-17Ra and IL-17Rb) function as highly divergent drivers of tissue immunity (towards type 17 or type 2, respectively). We analyze RNA induction, transcription factor activation, and protein stability to study the induction and maintenance of these and other receptors in lung epithelia and alveolar macrophages across different stimuls paradigms.
Another area of interest regards the activity of the ubiquitin system and its regulation of normal and pathological biology. Working within Dr. Mallampalli's Center for Acute Lung Injury, the group has pioneered the preclinical development of small molecule anti-inflammatory agents that target critical mediators of protein stability regulating inflammatory pathways. These studies have advanced the understanding of inflammatory signaling and led to development of first-in-class therapeutic agents that may someday be utilized to combat human inflammatory diseases. We have developed a human whole lung perfusion system as a preclinical system to evaluate tissue responses to endotoxemic lung injury.
Clinical Interest
I enjoy diverse clinical responsibilities in Pulmonary and Critical care medicine including the Presbyterian University Hospital Medical ICU and Pulmonary Consult services as well as ICU work in outlying hospitals in the UPMC network. I am clinically interested in the physiology and management of ARDS. We are working clinically and through research to better understand new potential therapies and genetic linkages for ARDS.
Educational Interest
I gain great satisfaction from my educational activities, most of which is hands-on. In the laboratory, I teach trainees important skills and concepts in molecular and cellular biology, animal experiments, data analysis, preparation of presentations, and writing for academic success. in clinical medicine, I include bedside teaching with hands-on immersion into the management of pulmonary disese and critical illness as well as didactic technical explorations of physiology and medicine. I facilitate our teams’ inclusion of published basic and clinical literature as part of the learning experience. I try to help build a foundation for the practice of not just evidence based, but also scientifically informed medicine in the next generation of physicians and physician scientists. I also sometimes lead group discussions for the pumlonary course in the medical school, and enjoy working with residents, fellows, and MD-PhD students to enhance their training in translational biomedical research.
For my complete bibliography, Click Here.
Selected Publications:
Mallampalli, RK, Coon, TA, Glasser, JR, Wang, C, Dunn, SR, Weathington, NM, Zhao, J, Zou, C, Zhao, Y, Chen, BB. Targeting F box protein Fbxo3 to control cytokine-driven inflammation. J Immunol. 2013; Nov 15;191(10): 5247-55.
Zou, C, Li, J, Xiong, S, Chen, S, Wu, Q, Li, X, Weathington, NM, Han, S, Snavely, C, Chen, BB, Mallampalli, RK. Mortality factor 4 like 1 protein mediates epithelial cell death in a mouse model of pneumonia. Sci Transl Med. 2015; 7(311): 311ra171.
Lendermon, EA, Dodd-O, JM, Coon, Ta, Miller, HL, Ganguly, S, Popescu, I, O'Donnell, CP, Cardenes, N, Levine, M, Rojas, M, Weathington, NM, Zhao, J, Zhao, Y, McDyer, JF. CD8(+)IL-17(+) T Cells Mediate Neutrophilic Airway Obliteration in T-bet-Deficient Mouse Lung Allograft Recipients. Am J Respir Cell Mol Biol. 2015; May; 52(5): 622-33.
Coon, TA, McKelvey, AC, Lear, T, Rajbhandari, S, Dunn, SR, Connelly, W, Zhao, JY, Han, S, Liu, Y, Weathington, NM, McVerry, BJ, Zhang, Y, Chen, BB. The proinflammatory role of HECTD2 in innate immunity and experimental lung injury. Sci Transl Med. 2015; Jul 8;7(295): 295ra109.
Weathington, NM, Snavely, CA, Chen, BB, Zhao, J, Zhao, Y, Mallampalli, RK. Glycogen synthase kinase-3ß stabilizes the interleukin (IL)-22 receptor from proteasomal degradation in murine lung epithelia. Journal of Biological Chemistry. 2014; June 20; 289(25): 17610-9.
Weathington, NM, Mallampalli, RK. Emerging therapies targeting the ubiquitin proteasome system in cancer. Journal of Clinical Investigation. 2014; Jan; 124(1): 6-12.
Weathington, NM, Sznajder, JI, Mallamapalli, RK. The emerging role of the ubiquitin proteasome in pulmonary biology and disease. American Journal of Respiratory and Critical Care Medicine. 2013; 188(5): 530-537.
Bratcher, PE, Weathington, NM, Nick, HJ, Jackson, PL, Snelgrove, RJ, Gaggar, A. MMP-9 cleaves SP-D and abrogates its innate immune functions in vitro. PLoS One. 2012; 7(7): e41881.
Djekic, UV, Gaggar, A, Weathington, NM. Attacking the multi-tiered proteolytic pathology of COPD: new insights from basic and translational studies. Pharmacology & Therapeutics. 2009; 121(2): 132-146.
van Houwelingen, AH, Weathington, NM, Verweij, V, Blalock, JE, Nijkamp, FP, Folkerts, G. Induction of lung emphysema is prevented by L-arginine-threonine-arginine. FASEB. 2008; 22(9): 3403-3408.
Sponsored Research/Activities
Title: Derangement of Alveolar Macrophage Immunometabolism by Prolonged Beta Agonist Therapy: Implications for Host Defense and Tissue Health
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R03 HL144888
Start Year: 2018
End Year: 2020
Title: Cellular Regulation of the IL-22 Receptor and its Importance in Lung Immunity
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: K08 HL126135
Start Year: 2014
End Year: 2019
Title: Developing Novel inhibitors of the E3 ligase CHIP to stabilize CFTR mutants
Role: Co-Director
Funding Agency: Cystic Fibrosis Foundation
Grant Number: RES
Start Year: 2018
End Year: 2020
Notable Achievements
American Lung Association - Biomedical Research Grant, 2016
Invited Seminar: Basic and Translational Seminars in Pulmonary Medicine. University of Pittsburgh School of Medicine., 2016
American Society of Clinical Investigators Young Physician Scientist Award Invited Presentation and Travel Award to attend the annual ASCI/AAP joint meeting, 2015
Session Chair and Poster Session Judge: Young Investigator Forum on pulmonary disease research. Munich Pittsburgh International Lung Conference., 2015
Invited Lecture: University of Pittsburgh School of Medicine, Physician Scientist Training Program Special Course. New molecular therapeutics targeting Integrin-TGF signaling in the pathophysiology of, 2015
K08 Grant; Cellular regulation of the IL-22 receptor and its importance in lung immunity, 2014-19
Invited Presenter with Travel Award; National Jewish and Astra Zeneca Young Investigators Forum in Respiratory Disease, Washington DC, 2014
Session Chair and presentation: Block symposium on Innate Immunity at the Microbe-Host Interface. IMMUNOLOGY 2014, 2014
National Jewish and Astra Zeneca Young Investigators Forum in Respiratory Disease Invited Presenter with Travel Award, 2014
University of Pittsburgh Department of Medicine Research Day Poster Award for excellence in research by a clinical fellow, 2013