Department of Medicine
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Division of Pulmonary, Allergy and Critical Care Medicine
Faculty Profiles
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Zeyu Xiong, MD, MS
Research Assistant Professor of Medicine
Email:
xiongz@upmc.edu
Phone: 412-692-2289
Contact
Office:
UPMC Montefiore Hospital, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
Phone:
412-692-2289
Fax:
412-692-2260
E-mail:
xiongz@upmc.edu
Administrative Assistant:
Shannon McKenzie
Email:
mckenziesj@upmc.edu
Phone:
412-692-2211
Fax:
412-692-2260
Education and Training
Education
MD, Shanxi College of Chinese Medicine, China, 1988
MS, West China University of Medical Sciences, 1995
Research Interest
1. Immunosuppressive effects of red cell transfusion has long been clinically recognized, but the underlying mechanisms for this effect remain elusive. Moreover, this effect may modify the outcomes of disease in critically ill patients with infection. We are currently investigating the mechanism of immune suppression in a combined bacterial pneumonia-red cell transfusion study and examining the hypothesis that red cell microparticles that accumulate within stored transfusates elicit an immunosuppressive phenotype through the suppression of NFkB gene activation.
2. Our lab has utmost interest in the role of macrophages and neutrophils in innate immune response, especially in bacteria infections. Despite recent advances in understanding macrophage activation, little is known regarding how human alveolar macrophages in health calibrate its transcriptional response to canonical TLR4 activation. With RNA-seq technology, we examined the full spectrum of LPS activation and determined whether the transcriptomic profile of human alveolar macrophages is distinguished by a TIR-domain-containing adapter-inducing interferon-ß (TRIF)-dominant type I interferon signature. We determined whether IRF-7 and USP-18 can influence downstream macrophage effector cytokine production such as IL-10. We show that IRF-7 siRNA knockdown enhanced LPS-induced IL-10 production in human monocyte-derived macrophages, and USP-18 overexpression attenuated LPS-induced production of IL-10 in RAW264.7 cells. Quantitative PCR confirmed upregulation of USP18, USP41, IL10, and IRF7. These results suggest that IRF-7 and predicted downstream target USP18, both elements of a type I interferon gene signature identified by RNA-Seq, may serve to fine-tune early cytokine response by calibrating IL-10 production in human alveolar macrophages.
Publications
For my complete bibliography,
Click Here
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Selected Publications:
Xiong, Z, Liu, E, Yan, Y, Silver, RT, Yang, F, Chen, IH, Chen, Y, Verstovsek, S, Wang, H,, Prchal, J, Yang, X-F. An unconventional antigen translated by a novel internal ribosome entry site elicits anti-tumor humoral immune reactions.
Journal of Immunology
. 2006; 177(7): 4907-4916.
Xiong Z, Shaibani A, Li Y-P, Yan Y, Zhang S, Yang Y,, Yang F, Wang H, Yang X-F. The expression of alternative splicing factor ASF/SF2 is downregulated in inflamed muscle.
Journal of Clinical Pathology
. 2006; 59: 855-861.
Xiong Z, Yan Y, Liu E, Silver RT, Yang F, Wang H, Prchal J, Yang X-F. Novel tumor antigens elicit anti-tumor humoral reactions in a subset of patients with polycythemia vera.
Clinical Immunology
. 2007; 122(3): 279-87.
Xiong Z, Liu E, Yan Y, Silver RT, Yang F, Chen IH, Hodge I, Verstovsek S, Segura FJ, Wang H, Prchal J, Yang X-F. A novel unconventional tumor antigen, MPD5, elicits anti-tumor humoral immune responses in a subset of patients with polycythemia vera.
International Journal of Immunopathology and Pharmacology
. 2007; 20(2): 373-80.
Xiong Z, Song J, Yan Y, Huang Y, Cowan A, Wang H, Yang XF. Higher expression of Bax in regulatory T cells increases vascular inflammation.
Frontiers in Bioscience
. 2008; May 1 (13): 7143-55.
Mangalmurti NS, Xiong Z, Hulver M, Ranganathan M, Liu XH, Oriss T, Rubin M, Triulzi D, Choi A, Lee JS. Loss of Red cell Chemokine Scavenging Promotes Transfusion Related Lung Inflammation.
Blood
. 2009; 113(5): 1158-66.
Xiong Z, Cavaretta J, Qu L, Stolz DB, Triulzi D, Lee JS. Red blood cell microparticles show altered inflammatory chemokine binding and release ligand upon interaction with platelets.
Transfusion
. 2011; March 51 (3): 610-21.
Xiong Z, Leme AS, Ray P, Shapiro SD, Lee JS. CX3CR1+Lung Mononuclear Phagocytes Spatially Confined to the Interstitium Produce TNF-alpha and IL-6 and Promote Cigarette Smoke-Induced Emphysema.
The Journal of Immunology
. 2011; March 1 186(5): 3206-14.
Xiong Z, Oriss TB, Cavaretta JP, Rosengart MR, Lee JS. Red cell microparticle enumeration: validation of a flow cytometric approach.
Vox Sanguinis
. 2012; July 103 (1): 42-8.
Nouraie M, Lee JS, Zhang Y, Kanias T, Zhao X, Xiong Z, Oriss TB, Zeng Q, Kato GJ, Gibbs JS, Hildesheim ME, Sachdev V, Barst RJ, Machado RF, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli E, Gladwin MT. Walk-PHASST Investigators and Patients. The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe.
Haematologica
. 2013; March 98 (3): 464-72.
