Department of Medicine
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Division of Cardiology

Faculty Profiles
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photo Paola Corti, PhD

Cardiology

Assistant Professor of Medicine

Email: pac47@pitt.edu

Phone: 412-624-0463
Contact
Office: BST E1200 - Vascular Medicine Institute
200 Lothrop St
Pittsburgh, PA 15213
 
Phone: 412-624-0463
Fax:
E-mail: pac47@pitt.edu
Research Interest
Dr. Corti's research focuses on the role of Globins proteins in embryonic development and cardiac regeneration. Dr. Corti characterized the zebrafish globins and found that nitrite improves heart regeneration in conditions of low oxygen. Using the zebrafish and mouse as models Dr. Corti is identifying the Globins as important players in maintaining nitric oxide homeostasis during embryonic development and adult metabolism.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Rochon E, Missinato MA, Xue J, Tejero J, Tsang M, Gladwin MT, Corti P. Nitrite improves heart regeneration in zebrafish. Antioxidants & Redox Signaling. 2019.
Rochon E, Corti P. Globins and nitric oxide homeostasis in fish embryonic development. Marine Genomics. 2019.
Amdahl MB, Petersen EE, Bocian K, Kaliszuk SJ, DeMartino AW, Tiwari SS, Sparacino-Watkins CE, Corti P, Rose JJ, Gladwin MT, Fago A, Tejero J. The zebrafish cytochrome b5/cytochrome b5 reductase/NADH system efficiently reduces cytoglobins 1 and 2: Conserved activity of cytochrome b5/cytochrome b5 reductases during vertebrate evolution. Biochemistry. 2019; 58(29): 3212-3223.
Rochon ER, Corti P, Gladwin MT. Hemoglobin a in pulmonary embolism: Ironing out nitric oxide signaling. American Journal of Respiratory Cell and Molecular Biology. 2017; 57(6): 639-641.
Amdahl MB, Sparacino-Watkins CE, Corti P, Gladwin MT, Tejero J. Efficient Reduction of Vertebrate Cytoglobins by the Cytochrome b5/Cytochrome b5 Reductase/NADH System. Biochemistry. 2017.
Corti P, Xue J, Tejero J, Wajih N, Sun M, Stolz DB, Tsang M, Kim-Shapiro DB, Gladwin MT. Globin X is a six-coordinate globin that reduces nitrite to nitric oxide in fish red blood cells. Proc Natl Acad Sci U S A. 2016; 113(30): 8538-43.
Corti P, Ieraci M, Tejero J. Characterization of zebrafish neuroglobin and cytoglobins 1 and 2: Zebrafish cytoglobins provide insights into the transition from six-coordinate to five-coordinate globins. Nitric Oxide. 2016; 53: 22-34.
Corti P, Gladwin MT. Is nitrite the circulating endocrine effector of remote ischemic preconditioning?. Circulation Research. 2014; 114(10): 1554-7.
Corti P, Tejero J, Gladwin MT. Evidence mounts that red cells and deoxyhemoglobin can reduce nitrite to bioactive NO to mediate intravascular endocrine NO signaling: commentary on "Anti-platelet effects of dietary nitrate in healthy volunteers: involvement of cGMP and influence of sex". Free Radical Biology and Medicine. 2013; 65: 1518-20.
Corti P, Young S, Chen CY, Patrick MJ, Rochon ER, Pekkan K, Roman BL. Interaction between alk1 and blood flow in the development of arteriovenous malformations. Development (Cambridge, England). 2011; 138(8): 1573-82.
Sponsored Research/Activities
Title: CYTOGLOBIN ROLE IN CILIA FUNCTION FOR THE CORRECT DEVELOPMENT OF CARDIAC LATERALITY THROUGH REGULATION OF NO LEVELS
Role: Principal Investigator
Funding Agency: Samuel and Emma Winters Foundation
Start Year: 2020
End Year: 2021
Title: Cytoglobin 2 Signals in Primary Cilia and Contributes to Normal Cardiac Development
Role: Principal Investigator
Funding Agency: American Heart Association
Start Year: 2018
End Year: 2021
Title: Study of the Role of Myoglobin in he Zebrafish Heart Regeneration
Role: Principal Investigator
Funding Agency: RiMed Foundation
Grant Number: FELLOW
Start Year: 2017
End Year: 2017
Notable Achievements
Winters Foundation Award, 2019
AHA Career Development Award, 2018
RiMED fellowship, 2012

Division Websites

Cardiology

Endocrinology and Metabolism

Gastroenterology, Hepatology and Nutrition

General Internal Medicine

Geriatric Medicine
Hematology/Oncology

Infectious Diseases

Pulmonary, Allergy and Critical Care Medicine

Renal-Electrolyte

Rheumatology and Clinical Immunology

Contact

Department of Medicine
1218 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
Email:  chairoff@pitt.edu
Phone:  412-648-9636
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