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Division of Cardiology
Faculty Profiles
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Paola Corti, PhD
Email:
pac47@pitt.edu
Phone: 412-624-0463
Contact
Office:
BST E1200 - Vascular Medicine Institute
200 Lothrop St
Pittsburgh, PA 15213
Phone:
412-624-0463
Fax:
412-648-5980
E-mail:
pac47@pitt.edu
Research Interest
Dr. Corti is studying the function of nitrite and the globins in vertebrate metabolism and cardiac signaling and the description of the chemical biology, signaling and biological function of the globins as well as their interactions with nitrite during the embryonic development and during the regeneration of the heart after amputation.
Publications
Selected Publications:
Amdahl MB, Sparacino-Watkins CE, Corti P, Gladwin MT, Tejero J. Efficient Reduction of Vertebrate Cytoglobins by the Cytochrome b5/Cytochrome b5 Reductase/NADH System.
Biochemistry
. 2017.
Corti P, Xue J, Tejero J, Wajih N, Sun M, Stolz DB, Tsang M, Kim-Shapiro DB, Gladwin MT. Globin X is a six-coordinate globin that reduces nitrite to nitric oxide in fish red blood cells.
Proc Natl Acad Sci U S A
. 2016; 113(30): 8538-43.
Corti P, Ieraci M, Tejero J. Characterization of zebrafish neuroglobin and cytoglobins 1 and 2: Zebrafish cytoglobins provide insights into the transition from six-coordinate to five-coordinate globins.
Nitric Oxide
. 2016; 53: 22-34.
Corti P, Gladwin MT. Is nitrite the circulating endocrine effector of remote ischemic preconditioning?.
Circulation Research
. 2014; 114(10): 1554-7.
Corti P, Tejero J, Gladwin MT. Evidence mounts that red cells and deoxyhemoglobin can reduce nitrite to bioactive NO to mediate intravascular endocrine NO signaling: commentary on "Anti-platelet effects of dietary nitrate in healthy volunteers: involvement of cGMP and influence of sex".
Free Radical Biology and Medicine
. 2013; 65: 1518-20.
Corti P, Young S, Chen CY, Patrick MJ, Rochon ER, Pekkan K, Roman BL. Interaction between alk1 and blood flow in the development of arteriovenous malformations.
Development (Cambridge, England)
. 2011; 138(8): 1573-82.
Sponsored Research/Activities
Title:
Study of the Role of Myoglobin in he Zebrafish Heart Regeneration
Role:
Principal Investigator
Funding Agency:
RiMed Foundation
Grant Number:
FELLOW
Start Year:
2017
End Year:
2017
My Lab
