Department of Medicine
Faculty Profiles by Division

Division of Cardiology

Faculty Profiles

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photo Toren Finkel, MD, PhD

Cardiology

Distinguished Professor of Medicine, Division of Cardiology

G. Nicholas Beckwith III and Dorothy B. Beckwith Chair in Translational Medicine

Director, Aging Institute of UPMC and Pitt

Email: finkelt@pitt.edu

Phone: 412-383-4409

Contact
Office: 555 Bridgeside Point I
100 Technology Drive
Pittsburgh, PA 15219
 
Phone: 412-383-4409
Fax: 412-383-9055
E-mail: finkelt@pitt.edu
Administrative Assistant:
Kathy Brickett
Address: 571.1 Bridgeside Point I
100 Technology Drive
Pittsburgh, PA 15219
Email: kab389@pitt.edu
Phone: 412-383-4416
Fax: 412-383-9055
Education and Training
Education
MD, Harvard Medical School, 1986
PhD, Biophysics, Harvard University School of Arts & Sciences, 1986
BS, Physics, University of Maryland, 1979
Training
Fellowship in Cardiology, Johns Hopkins Hospital, 1992
Internship and Residency in Internal Medicine, Massachusetts General Hospital, 1989
Research Interest
Dr. Finkel's lab is interested in the intersection of metabolism, mitochondrial function and aging. Current projects include the link between impaired autophagy and vascular aging, the molecular basis that regulates mitochondrial calcium entry, molecular regulation of cellular senescence and the development of novel small molecules that regulate critical age-related pathways.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Sundaresan M, Yu ZX, Ferrans VJ, Irani K, Finkel T. Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science. 1995; 270: 296-299.
Nemoto S, Finkel T. Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science. 2002; 295: 2450-2452.
Hill JM, Zalos G, Halcox JP, Schenke WH, Waclawiw MA, Quyyumi AA, Finkel T. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. New England Journal of Medicine. 2003; 348: 593-600.
Nemoto S, Fergusson MM, Finkel T. Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science. 2004; 306: 2105-2108.
Liu H, Fergusson MM, Castilho RM, Liu J, Cao L, chen J, Malide D, Rovira II, Schimel D, Kuo CJ, Gutkind JS, Hwang PM, Finkel T. Augmented Wnt signaling in a mammalian model of accelerated aging. Science. 2007; 317: 803-806.
Lee IH, Cao L, Mostosklavsky R, Lombard DB, Liu J, Bruns N, Tsokos M, Alt FW, Finkel T. A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proceedings of the National Academy of Science. 2008; 105: 3374-3379.
Liu J, Cao L, Chen J, Song S, Lee IH, Quijano C, Liu H, Kenvanfar K, Chen H, Cao LY, Ahn BH, Kumar NG, Rovira II, Xu XL, van Lohuizen M, Motoyama N, Deng CX, Finkel T. Bmi1 regulates mitochondrial function and the DNA damage response pathway. Nature. 2009; 459: 387-392.
Sponsored Research/Activities
Title: STUDYING METHIONINE FLUX AND ITS ROLE IN AGING AND NEURODGENERATION
Role: Principal Investigator
Funding Agency: National Institute of Aging
Grant Number: R00 AG057792
Start Year: 2020
End Year: 2023
Title: Identification and Phase I testing of FDA approved compounds for COVID-19
Role: Principal Investigator
Funding Agency: Jewish Healthcare Foundation
Grant Number: RES
Start Year: 2020
End Year: 2020
Title: The Role of Calcium Entry Through the Mitochondrial Uniporter in Regulating Cardiac Metabolism and Physiology
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL142589
Start Year: 2019
End Year: 2023
Title: Vascular Autophagy as a Mediator of Vascular Aging and Homeostasis
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL142663
Start Year: 2018
End Year: 2022
Title: Vascular Autophagy and HGPS Progression
Role: Principal Investigator
Funding Agency: Progeria Research Foundation
Start Year: 2017
End Year: 2020
Title: Vascular Autophagy and HGPS Pprogression
Role: Principal Investigator
Funding Agency: Leducq Foundation
Start Year: 2017
End Year: 2018
Title: Defining cellular receptors for the Bacillus cereus hemolysin BL toxin (HBL) and the development of anti-HBL therapies
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R01 AI145879
Start Year: 2020
End Year: 2025
Title: Molecular mechanisms and novel biological-based therapies for anthrax lethal toxin-induced mortality
Role: Co-Investigator
Funding Agency: National Institute of Health
Grant Number: R56 AI148134
Start Year: 2020
End Year: 2025
Title: DCAF7/HDAC4/TFEB Axis in Acute Lung Injury
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL142777
Start Year: 2018
End Year: 2023
Title: Pittsburgh Older Americans Independence Center
Role: Core Leader
Funding Agency: National Institute of Aging
Grant Number: P30 AG024827
Start Year: 2017
End Year: 2020
Notable Achievements
Elected, National Academy of Medicine, 2020
Elected, Fellow American Association for the Advancement of Science, 2013
Elected, Association of American Physicians, 2009
Elected, American Society for Clinical Research, 2002
NHLBI Orloff Innovation Award, 2016
NHLBI Director's Award-Outstanding Translational Science, 2015
Ellison Medical Foundation Senior Scholar in Aging Award, 2006-2010