Department of Medicine
Faculty Profiles by Division

Division of Cardiology

Faculty Profiles

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photo Jie Liu, PhD


Research Associate Professor of Medicine, Division of Cardiology


Phone: 412-383-4418

Office: 450 Bridgeside Point I
100 Technology Drive
Pittsburgh, PA 15219
Phone: 412-383-4418
Fax: 412-383-9055
Education and Training
PhD, Academy of Military Medical Sciences, Beijing, China, 1987
BS, Heilongjiang University, Harbin, China, 1987
Postdoctoral, Molecular Cardiology, University of Texas Medical Branch, Galveston, TX, 1997
Research Fellow, Metabolic Diseases, NIDDK-NIH, Bethesda, MD, 2001
Research Interest
Dr. Jie Liu’s research interests include the study of mitochondrial function in the context of stem cells, growth, and metabolism; vascular biology; and genetic imprinting of the stimulatory G protein alpha-subunit in human genetic disease psuedohypoparathryroidism type 1B.
For my complete bibliography, Click Here.
Selected Publications:
Liu J, Cao L, Chen J, Song S, Lee IH, Quijano C, Liu H, Keyvanfar K, Chen H, Cao LY, Ahn BH, Kumar NG, Rovira II, XU XL, van Lohuizen M, Motoyama N, Deng CX, Finkel T. Bmi1 regulates mitochondrial function and the DNA damage response pathway. Nature. 2009; 459(7245): 387-392.
Wu JJ, Liu J, Chen EB, Wang JJ, Cao L, Narayan N, Fergusson MM, Rovira II, Allen M, Springer DA, Lago CU, Zhang S, DuBois W, Ward T, deCabo R, Gavrilova O, Mock B, Finkel T. Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression. Cell Reports. 2013; 4(5): 913-920.
Pan X, Liu J, Nguyen T, Liu C, Sun J, Teng Y, Fergusson MM, Rovira II, Allen M, Springer DA, Aponte AM, Gucek M, Balaban RS, Murphy E, Finkel T. The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter. Nature Cell Biology. 2013; 15(12): 1464-1472.
Liu JC, Liu J, Holmström KM, Menazza S, Parks RJ, Fergusson MM, Yu ZX, Springer DA, Halsey C, Liu C, Murphy E, Finkel T. MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload. Cell Reports. 2016; 16(6): 1561-1573.
Liu S, Liu J, Ma Q, Cao L, Fattah RJ, Yu Z, Bugge TH, Finkel T, Leppla SH. Solid tumor therapy by selectively targeting stromal endothelial cells. Proceedings of the National Academy of Science USA. 2016; 113(28): E4079-E4087.
Liu S, Zhang Y, Moayeri M, Liu J, Crown D, Fattah RJ, Wein AN, Yu ZX, Finkel T, Leppla SH. Key tissue targets responsible for anthrax-toxin-induced lethality. Nature. 2013; 501(7465): 63-68.
Torisu T, Torisu K, Lee IH, Liu J, Malide D, Combs CA, Wu XS, Rovira II, Fergusson MM, Weigart R, Connelly PS, Daniels MP, Komatsu M, Cao L, Finkel T. Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor. Nature Medicine. 2013; 19(10): 1281-1287.
Liu J, Chen M, Deng C, Bourc'his D, Nealon JG, Erlichman B, Bestor TH, Weinstein LS. Identification of the control region for tissue-specific imprinting of the stimulatory G protein alpha-subunit. Proceedings of the National Academy of Science USA. 2005; 102(15): 5513-5518.
Liu J, Nealon JG, Weinstein LS. Distinct patterns of abnormal GNAS imprinting in familial and sporadic pseudohypoparathyroidism type IB. Human Molecular Genetics. 2005; 14(1): 95-102.
Liu J, Litman D, Rosenberg MJ, Yu S, Biesecker LG, Weinstein LS. A GNAS1 imprinting defect in pseudohypoparathyroidism type IB. Journal of Clinical Investigation. 2000; 106(9): 1167-1174.
Sponsored Research/Activities
Title: Defining cellular receptors for the Bacillus cereus hemolysin BL toxin (HBL) and the development of anti-HBL therapies
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R01 AI145879
Start Year: 2020
End Year: 2025
Title: Molecular mechanisms and novel biological-based therapies for anthrax lethal toxin-induced mortality
Role: Co-Investigator
Funding Agency: National Institute of Health
Grant Number: R56 AI148134
Start Year: 2020
End Year: 2025
Title: Vascular Autophagy as a Mediator of Vascular Aging and Homeostasis
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL142663
Start Year: 2018
End Year: 2022
Title: Vascular Autophagy and HGPS Pprogression
Role: Co-Investigator
Funding Agency: Leducq Foundation
Grant Number: RES
Start Year: 2017
End Year: 2019
Notable Achievements
NHLBI Core Innovation Award, 2017
United States Government Service Award (Brown Medal), 2016
NHLBI Orloff Innovations Award, 2016
NHLBI Director's Award for Outstanding Translational Science, 2015
NHLBI Division of Intramural Research Orloff Science Award, 2013