Department of Medicine
Faculty Profiles by Division

Division of Cardiology

Faculty Profiles

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photo Guy Salama, PhD


Professor of Medicine


Phone: 412-648-9354

Office: 3550 Terrace Street
Suite S 628 Scaife Hall
Pittsburgh, PA 16261
Phone: 412-648-9354
Fax: 412-648-5991
Administrative Assistant:
Tina Furlano
Education and Training
BS, City College of New York, 1970
MS, University of Pennsylvania, 1972
PhD, University of Pennsylvania, 1977
Postdoctoral, University of Pennsylvania, 1979
Research Interest
A central goal of Dr. Salama's laboratory is to elucidate the mechanisms responsible for the initiation and termination of cardiac arrhythmias. To achieve this, they have developed the use of voltage-sensitive dyes and high temporal and spatial resolution optical techniques to map patterns of action potential (AP) propagation and repolarization. These novel methods are used to elucidate of the mechanisms that generate spatial heterogeneities of AP durations and the interplay between dispersion of repolarization (DOR) and anisotropic conduction velocities (CV). Animal models for cardiac arrhythmias include: acute ischemia in the guinea pig heart and 2 rabbit models of the long QT syndrome (LQTS). A number of mechanisms are being investigated as factors that promote arrhythmias in the LQTS: elevation of extracellular K+, sympathetic stimulation, and the role of spontaneous Ca2+ oscillation from the sarcoplasmic reticulum. Mapping spatial heterogeneities of intracellular Ca2+ transients in mammalian hearts using Ca2+ indicator dyes and imaging techniques. Once the normal heterogeneities of Ca2+ are determined, changes in Ca2+ transients will be analyzed in a wide range of physiological conditions to determined parameter that modulate Ca2+ transients. This laboratory has been at the forefront of the investigation of the role of sulfhydryl oxidation-reduction as a mechanisms to regulate Ca2+ release from the sarcoplasmic reticulum (SR). They are continuing this line of work in very exciting direction.
For my complete bibliography, Click Here.
Selected Publications:
Henry BL, Gabris B, Li Q, Martin B, Giannini M, Parikh A, Patel D, Haney J, Schwartzman DS, Shroff SG, Salama G. Relaxin suppresses atrial fibrillation in aged rats by reversing fibrosis and upregulating Na(+) channels. Heart Rhythm. 2016; 13(4) PMID 26711798: 983-91.
Nemec J, Kim JJ, Salama G. The link between abnormal calcium handling and electrical instability in acquired long QT syndrome - Does calcium precipitate arrhythmic storms?. Prog Biophys Mol Biol. 2016; 120(1-3): 210-21.
Kim JJ, Nemec J, Li Q, Salama G. Synchronous systolic subcellular Ca2+-elevations underlie ventricular arrhythmia in drug-induced long QT type 2. Circ Arrhythm Electrophysiol. 2015; 8(3): 703-12.
Kim JJ, Yang L, Lin B, Zhu X, Sun B, Kaplan AD, Bett GC, Rasmusson RL, London B, Salama G. Mechanism of automaticity in cardiomyocytes derived from human induced pluripotent stem cells. J Mol Cell Cardiol. 2015; 81 (Apr): 81-93.
Tanha M, Chakraborty SK, Gabris B, Waggoner AS, Salama G, Yaron D. Computational and experimental characterization of a fluorescent dye for detection of potassium ion concentration. J Phys Chem A. 2014; 118(42): 9837-43.
Tchao J, Kim JJ, Lin B, Salama G, Lo CW, Yang L, Tobita K. Engineered Human Muscle Tissue from Skeletal Muscle Derived Stem Cells and Induced Pluripotent Stem Cell Derived Cardiac Cells. Int J Tissue Eng. 2013; Sep 28.
Lu TY, Lin B, Kim J, Sullivan M, Tobita K, Salama G, Yang L. Repopulation of decellularized mouse heart with human induced pluripotent stem cell-derived cardiovascular progenitor cells. Nat Commun. 2013; 4(2307).
Parikh A, Patel D, McTiernan CF, Xiang W, Haney J, Yang L, Lin B, Kaplan AD, Bett GC, Rasmusson RL, Shroff SG, Schwartzman D, Salama G. Relaxin suppresses atrial fibrillation by reversing fibrosis and myocyte hypertrophy and increasing conduction velocity and sodium current in spontaneously hypertensive rat hearts. Circ Res. 2013; 113(3): 313-21.
Kim JJ, Nemec J, Papp R, Strongin R, Abramson JJ, Salama G. Bradycardia alters Ca(2+) dynamics enhancing dispersion of repolarization and arrhythmia risk. Am J Physiol Heart Circ Physiol. 2013; 304(6): H848-60.
Sponsored Research/Activities
Title: Relaxin as a therapy for Heart Failure with preserved Ejection Fraction (HFpEF)
Role: Principal Investigator
Funding Agency: Relaxera Pharmazuetische Gesellschaft mbH & Co. KG
Grant Number: RES
Start Year: 2021
End Year: 2023
Title: Comprehensive Structural and functional mapping of the mammalian cardiac nervous system
Role: Principal Investigator
Funding Agency: University of California Los Angeles
Grant Number: OT2
Start Year: 2017
End Year: 2019
Title: Bladder Mucosal Dysfunction During Aging
Role: Co-Investigator
Funding Agency: National Institute of Aging
Grant Number: R01 AG056944
Start Year: 2018
End Year: 2023
Title: Bladder Mucosal Dysfunction During Aging
Role: Co-Investigator
Funding Agency: National Institute of Aging
Grant Number: R01 AG056944
Start Year: 2018
End Year: 2023