Department of Medicine
Faculty Profiles by Division

Division of Cardiology

Faculty Profiles

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photo Shiori Sekine, PhD

Cardiology

Assistant Professor of Medicine, Division of Cardiology

Email: sekine@pitt.edu

Phone: 412-383-0867

Contact
Office: 568 Bridgeside Point I
100 Technology Drive
Pittsburgh, PA 15219
 
Phone: 412-383-0867
Fax: 412-383-9055
E-mail: sekine@pitt.edu
Administrative Assistant:
Kathy Brickett
Address: 571.1 Bridgeside Point I
100 Technology Drive
Pittsburgh, PA 15219
Email: kab389@pitt.edu
Phone: 412-383-4416
Fax: 412-383-9055
Education and Training
Education
PhD, The University of Tokyo, Japan, 2011
M.S., The University of Tokyo, Japan, 2008
B.S., The University of Tokyo, Japan, 2006
Training
Research Fellow, National Institute of Health, 2019
Fellowship, The University of Tokyo, Japan, 2013
Research Interest
Mitochondria dysfunction is associated with various diseases and aging. To maintain healthy mitochondrial network, mitochondria are equipped with several systems that can evoke stress-signaling pathways. My lab is focusing on the stress-sensing mechanisms of mitochondrial proteins. We are especially interested in the stress-dependent regulation of mitochondrial proteases and mitochondrial import machineries. My research goal is to provide therapeutic targets for mitochondria dysfunction-related diseases through the manipulation of stress-signaling in mitochondria.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Sekine, S., Wang C, Sideris DP, Bunker E, Zhang Z, Youle RJ. Reciprocal roles of Tom7 and OMA1 during mitochondrial import and activation of PINK1. Molecular Cell. 2019; 73(5): 1028-1043.
Sekine, S., Youle, RJ. PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol. BMC Biology. 2018; 16(1): 2.
Sekine, S., Yao, A, Hattori, K, Sugawara, S, Naguro, I, Koike, M, Uchiyama Y, Takeda K, Ichijo H. The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress. EBioMedicine. 2016; 5: 82–92.
Sekine, S., Ichijo H. Mitochondrial proteolysis: its emerging roles in stress responses. Biochim Biophys Acta. 2015; 1850(2): 274-280.
Sekine, S., Kanamaru Y, Koike M, Nishihara A, Okada M, Kinoshita H, Kamiyama M, Maruyama J, Uchiyama Y, Ishihara N, Takeda k, Ichijo H. Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5. The Journal of Biological Chemistry. 2012; 287(41): 34635–34645.
Notable Achievements
The Japan Society for the Promotion of Science (JSPS), Postdoctoral Fellowships for Research Abroad, 2016–2018