Department of Medicine
Faculty Profiles by Division

Division of Cardiology

Faculty Profiles

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photo Matthew L Steinhauser, MD


Associate Professor of Medicine


Phone: 412-383-7054

Office: 100 Technology Center Drive
Suite 558
Pittsburgh, PA 15219
Phone: 412-383-7054
Fax: 412-383-9055
Administrative Assistant:
Kathy Brickett
Address: 100 Technology Drive; 571.1
Pittsburgh, PA 15219
Phone: 416-416-4416
Administrative Assistant:
Tina Furlano
Address: 200 Lothrop Street
HVI PUH 711.2 WC
Pittsburgh, PA 15213
Phone: 412-802-3131
Fax: 412-648-6358
Education and Training
MD, University of Michigan Medical School, 2002
Internship, Columbia University Medical Center, 2003
Residency, Columbia University Medical Center, 2005
Chief Resident, Columbia University Medical Center, 2006
Clinical and Research Fellowship, Brigham and Women's Hospital, 2011
Clinical Interest
Dr. Steinhauser's clinical interests include General Cardiology and Cardiovascular Prevention.
For my complete bibliography, Click Here.
Selected Publications:
Fazeli PK, Lun M, Kim SM, Bredella MA, WRight S, Zhang Y, Lee H, Catana C, Klibanski A, Patwari P, Steinhauser ML. FGF21 and the late adaptive response to starvation in humans. Journal of Clinical Investigation. 2015; 125: 4601-11.
Chu AY, Deng X, Fisher VA, Drong A, Zhang Y, Feitosa MF, Liu CT, Weeks O, Choh AC, Duan Q, Dyer TD, Eicher JD, Guo X, Heard-Costa NL, Kacprowski T, Kent JW Jr, Lange LA, ..., Steinhauser ML, Fox CS. Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation. Nature Genetics. 2017; 49: 125-30.
Guillermier C, Fazeli PK, Kim S, Lun M, Zuflacht JP, Milian J, Lee H, Francios Saint Cyr H, Horreard F, Larson D, Rosen ED, Lee RT, Lechene CP, Steinhauser ML. Imaging mass spectrometry demonstrates age related decline in human adipose plasticity. JCI Insight. 2017; 2: e90349.
Zhang y, Federation AJ, Kim S, O'Keefe J, Lun M, Xiang D, Brown JD, Steinhauser ML. Targeting nuclear receptor NR4A1 dependent adipocyte progenitor quiescence promotes metabolic adaptation to obesity. Journal of Clinical Investigation. 2018; 128(11): 4898-4911.
Narendra DP, Guillermier C, Gyngard F, Huang X, Ward ME, Steinhauser ML. Coupling APEX labeling to imaging mass spectrometry of single organelles reveals heterogeneity in lysosomal protein turnover. Journal of Cell Biology. 2020; 219(1): e201901097.
Zhang Y, Guillermier C, De Raedt T, Cos A, Maertens O, Yimlamai D, Lun M, Whitney A, Maas RL, Goessling W, Cichowski K, Steinhauser ML. Imaging mass spectrometry reveals tumor metabolic heterogeneity. iScience. 2020; 23(8): 101355.
Steinhauser ML, Olenchock BA, O'Keefe J, Lun M, Pierce KA, Lee H, Pantano L, Klibanski A, Shulman GI, Clish CB, Fazeli PK. The circulating metabolome of human starvation. JCI Insight. 2018; 3(16).
Kim SM, Lun M, Wang M, Senyo S, Guillermier C, Patwari P, Steinhauser ML. Loss of White Adipose Hyperplastic Potential is Associated with Enhanced Susceptibility to Insulin Resistance. Cell Metabolism. 2014; 20(6): 1049-1058.
Sponsored Research/Activities
Title: Quantification of the decline of heart muscle cell proliferation and its reversal in pediatric patients
Role: Principal Investigator
Funding Agency: National Institute of Health
Grant Number: R01
Start Year: 2020
End Year: 2021
Role: Principal Investigator
Funding Agency: Vanderbilt University / National Heart, Lung, & Blood Institute
Grant Number: R01 HL146654
Start Year: 2020
End Year: 2021
Title: A new modality to image tumor metabolic heterogeneity at subcellular resolution
Role: Principal Investigator
Funding Agency: National Cancer Institute
Grant Number: DP2
Start Year: 2020
End Year: 2021
Notable Achievements
Board Certified, Internal Medicine, 2005
Board Certified, Cardiovascular Disease, 2009