Department of Medicine
Faculty Profiles by Division

Division of General Internal Medicine

Faculty Profiles

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photo Danielle Heffner, MD

General Internal Medicine

Clinical Assistant Professor of Medicine


Phone: 412-692-4882

Office: UPMC Montefiore, G100
200 Lothrop Street
Pittsburgh, PA 15213
Phone: 412-692-4882
Fax: 412-692-4555
Administrative Assistant:
Crystal Lisowski
Phone: 412-692-4882
Fax: 412-692-4555
Education and Training
BA Neuroscience, University of Virginia (Charlottesville, VA), 2013
MD, University of Pittsburgh (Pittsburgh, PA), 2017
Internal Medicine Residency, University of Pittsburgh Medical Center (Pittsburgh, PA), 2020
Research Interest
Dr. Heffner has previously conducted research in nervous system development, telemedicine, and clinician burnout, subsequently earning several awards for the quality of her work.

Recent Presentations:

Telemedicine in Ischemic Stroke Treatment. IXth Annual Meeting of the Pennsylvania Neurological Society, 2014 (Pittsburgh, PA).
Clinical Interest
Dr. Heffner is a Clinical Assistant Professor of Medicine and staff hospitalist in the Division of General Internal Medicine, Section of Hospital Medicine. She earned a BA in Neuroscience at the University of Virginia before attending medical school at the University of Pittsburgh. She joined the faculty at the University in Pittsburgh in 2020 after completing her residency in internal medicine at UPMC. She has also volunteered extensively and served as a mentor to 1st year medical students.
For my complete bibliography, Click Here.
Selected Publications:
Kuhn, KD, Edamura, K, Bhatia, N, Cheng, I, Clark, SA, Haynes, CV, Heffner, DL, Kabir, F, Velasquez, J, Spano, AJ, Deppman, CD, Keeler, AB. Molecular Dissection of TNFR-TNFa Bidirectional Signaling Reveals Both Cooperative and Antagonistic Interactions With p75 Neurotrophic Factor Receptor in Axon Patterning. Molecular and Cellular Neurosciences. 2020; 103: 103467.
Heffner, DL, Thirumala, PD, Pokharna, P, Chang, Y, Wechsler, L. Outcomes of Spoke-Retained Telestroke Patients Versus Hub-Treated Patients After Intravenous Thrombolysis: Telestroke Patient Outcomes After Thrombolysis. Stroke. 2015; 46(11): 3161-7.
Wheeler, MA, Heffner, DL, Kim, S, Espy, SM, Spano, AJ, Cleland, CL, Deppmann, CD. TNFa/TNFR1 signaling is required for the development and function of primary nociceptors. Neuron. 2014; 82(3): 587-602.
Kodis, EJ, Smindak, RJ, Kefauver, JM, Heffner, DL. First Messengers. Encyclopedia of Life Sciences. 2012.
Notable Achievements
HONORS Research Award, American Society of Hematology, 2019
Resident of the Month, UPMC Internal Medicine Residency, 2017
Certificate of Merit for Excellence in Scholarly Research Project, University of Pittsburgh School of Medicine, 2017
2nd place poster, IXth Annual Meeting of the Pennsylvania Neurological Society, 2014
Dean's Summer Research Award, University of Pittsburgh School of Medicine, 2014