Department of Medicine
Faculty Profiles by Division

Division of Endocrinology and Metabolism

Faculty Profiles

[Return To Index page]
photo Krystle A Frahm, PhD

Instructor in Medicine


Phone: 412-648-9770

Office: 200 Lothrop Street
W1026 BST
Pittsburgh, PA 15213
Phone: 412-648-9770
Fax: 412-648-3290
Education and Training
B.A., Texas State University, 2005
M.A., Texas State University, 2007
Ph.D., Colorado State University, 2014
Postdoctoral Scholar, University of Pittsburgh, 2017
Research Interest
Dr. Frahm's research interests focus on how endogenous and exogenous factors disrupt hypothalamic function resulting in physiological and behavioral consequences. Current studies are primarily focused on a novel human obesity risk variant and determining how it regulates energy homeostasis and stress responses in a sex-specific manner.
Educational Interest
Dr. Frahm’s educational mission to encouraging the next generation of scientists through teaching and mentoring at the undergraduate and graduate level. She also promotes basic science research through participating and organizing community outreach at the local level.
Selected Publications:
Frahm, K.A., Waldman, J.K., Luthra, S., Rudine, A.C., Monaghan-Nichols, A.P., Chandran, U.R., DeFranco, D.B. A comparison of the sexually dimorphic dexamethasone transcriptome in mouse cerebral cortical and hypothalamic embryonic neural stem cells. Mol Cell Endocrinol. 2017.
Frahm, K.A., Peffer, M.E., Zhang, J.Y., Luthra, S., Chakka, A.B., Couger, M.B., Chandran, U.R., Monaghan-Nichols, A.P., DeFranco, D.B. The dexamethasone transcriptome in hypothalamic embryonic neural stem cells. Mol Endocrinol. 2016; 30(1): 144-54.
Frahm, K.A., Tobet, S.A. Development of the blood-brain barrier within the paraventricular nucleus of the hypothalamus: influence of fetal glucocorticoid excess. Brain Struct Funct. 2015; 220(4): 2225-34.
Sponsored Research/Activities
Title: Impact of CREBRF and its Obesity-Risk Variant on Hypothalamic Glucocorticoid and Neuroendocrine Output Using Molecular, Cellular, and Physiological Approaches
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: K01 DK115543
Start Year: 2017
End Year: 2022
Title: The Development and Role of CREBRF on Hypothalamic Regulation of Feeding Behavior and Obesity
Role: Principal Investigator
Funding Agency: American Diabetes Association
Grant Number: RES
Start Year: 2017
End Year: 2020
Notable Achievements
The Endocrine Society Early Investigator Award, 2018
NIH Loan Repayment Ambassador, 2016-present
Journal of Molecular Endocrinology Author Feature, 2016
University of Pittsburgh Postdoctoral Association Data & Dine Travel Award, 2016
Highest Honors & Best Overall- Colorado State University Cell & Molecular Biology Annual Graduate Poster Symposium, 2014
Endocrine Society Early Career Forum Travel Award, 2014-2015
Endocrine Society Outstanding Abstract Award, 2013
US-South American Workshop in Neuroendocrinology Young Investigator Travel Award, 2011 & 2013
Thornburg Graduate Research Excellence Award, 2012