Department of Medicine
Faculty Profiles by Division

Division of Endocrinology and Metabolism

Faculty Profiles

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photo Ruya Liu, MD, PhD

Instructor in Medicine


Phone: 412-648-9770

Office: 200 Lothrop Street
W1055 BST
Pittsburgh, PA 15213
Phone: 412-648-9770
Fax: 412-648-3290
Administrative Assistant:
Chelsea Dempsey
Address: 200 Lothrop Street
W1026 Biomedical Science Tower
Pittsburgh, PA 15213
Phone: 412-648-9770
Fax: 412-648-3290
Education and Training
MD, Beihua University, China, 2007
PhD, Shanghai Jiaotong University, China, 2012
Intern, Faculty of Medicine, Beihua University, China, 2007
Research Fellow, Massachusetts General Hospital, 2013
Postdoctoral Fellow, Houston Methodist Research Institute, 2014
Postdoctoral Associate, Baylor College of Medicine, 2015
Research Interest
Dr. Liu's research focuses broadly on understanding the etiology of endocrine and metabolic diseases. Her current studies are mainly on the function of Hippo pathway in cardiac muscle and pancreatic beta-cells. Specifically, (1)Heart disease remains the leading cause of death in the world, leading to a pressing need of discovery of nodal effectors in cardiac function. Dr. Liu has identified the non-redundant roles of Tead1, Hippo downstream transcriptional effector, in the maintenance of normal cardiac function and cardiomyocytes proliferation; (2)In line with the essential role of Hippo pathway in the regulation of tissue homeostasis, Dr. Liu expanded her research on the exploration of Hippo components in the development of pancreatic endocrine lineage specification and beta-cell maturation. The long-term goal is to identify potential therapeutic target(s) for modulating metabolism and accordingly improving public health.
Selected Publications:
Liu, R., Jagannathan, R., Li, F., Lee, J., Balasubramanyam, N., Kim, B. S., Yang, P., Yechoor, V. K., Moulik, M. Tead1 is required for perinatal cardiomyocyte proliferation. PLoS One. 2019; 14(2): e0212017.
Liu, R., Lee, J., Kim, B. S., Wang, Q., Buxton, S. K., Balasubramanyam, N., Kim, J. J., Dong, J., Zhang, A., Li, S., Gupte, A. A., Hamilton, D. J., Martin, J. F., Rodney, G. G., Coarfa, C., Wehrens, X. HT., Yechoor, V. K., Moulik, M. Tead1 is required for maintaining adult cardiomyocyte function and its loss results in lethal dilated cardiomyopathy. JCI Insight. 2017; 2(17): e93343.
Li, R, Buras, E, Lee, J, Liu, R, Liu, V, Espiritu, C, Ozer, K, Thompson, B, Nally, L, Yuan, G, Oka, K, Chang, B, Samson, S, Yechoor, V, Chan, L. Gene therapy with Neurogenin3, Betacellulin and SOCS-1 Reverses Diabetes in NOD Mice. Gene Therapy. 2015.
Sponsored Research/Activities
Title: TEAD1 as a Novel Regulator of Mitochondrial Function in Cardiomyocytes
Role: Principal Investigator
Funding Agency: American Heart Association
Start Year: 2019
End Year: 2022
Title: Tead1 and Cardiac Adaptation
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01
Start Year: 2019
End Year: 2024
Title: Circadian Clock and Beta Cell Stress Adaptation
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK097160
Start Year: 2018
End Year: 2019
Notable Achievements
Basic Cardiovascular Sciences (BCVS) Abstract Travel Grant, AHA Scientific Sessions, 2018
Keystone Symposia Scholarship (NHLBI)- Mitochondria, Metabolism and Heart Failure, 2015
1st Place Best Presentation, Department of Medicine Housestaff Research Symposium, Baylor College of Medicine, 2015