Department of Medicine
Faculty Profiles by Division

Division of Endocrinology and Metabolism

Faculty Profiles

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photo Robert M. O'Doherty, PhD

Endocrinology and Metabolism

Professor of Medicine

Professor of Biochemistry and Molecular Genetics

Director, T32 Diabetes and Endocrinology Training Program

Co-Director, Center for Metabolic and Mitochondrial Medicine (C3M)

Email: rmo1@pitt.edu

Phone: 412-648-9770

Contact
Office: W1054 Biomedical Science Tower
200 Lothrop Street
Pittsburgh, PA 15213
 
Phone: 412-648-9770
Fax: 412-648-3290
E-mail: rmo1@pitt.edu
Administrative Assistant:
Emily Welsh
Address: W1026 Biomedical Science Tower
200 Lothrop Street
Pittsburgh, PA 15213
Email: ejw74@pitt.edu
Phone: 412-648-9770
Fax: 412-648-3290
Education and Training
Education
B.A., University of Dublin, 1986
PhD, Vanderbilt University, 1995
Training
Postdoctoral Fellow, Diabetes/Obesity, University of Texas, Southwestern Medical Center, 1998
Research Interest
Dr. O'Doherty's overarching research interests are in questions related to the association between states of over nutrition and resulting metabolic disturbances, most notably obesity, NAFLD, and Type 2 Diabetes. Dr. O'Doherty has accumulated nearly twenty five years experience in this arena, utilizing a range of metabolic, physiological, biochemical, molecular and immunological approaches in a range of models, notably the mouse and rat, primary tissue culture, and immortal cell lines. The major foci of his current research efforts are in the area of immunometabolism, that is the role of immune system in the regulation of metabolism.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Thapa, D., Wu, K., Stoner, M. W., Xie, B., Zhang, M., Manning, J. R., Lu, Z., Li, J. H., Chen, Y., Gucek, M., Playford, M. P., Mehta, N. N., Harmon, D., O'Doherty, R. M., Jurczak, M. J., Sack, M. N., Scott, I. The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial ß-oxidation enzyme HADHA. J Biol Chem. 2018; Epub ahead of print.
Bhatt, B. A., Dedousis, N., Sipula, I. J., O'Doherty, R. M. Elevated metabolic rate and skeletal muscle oxidative metabolism contribute to the reduced susceptibility of NF-?B p50 null mice to obesity. Physiol Rep. 2018; 6(18): e13836.
Harmon, D. B., Wu, C., Dedousis, N., Sipula, I. J., Stefanovic-Racic, M., Schoiswohl, G., O'Donnell, C. P., Alonso, L. C., Kershaw, E. E., Kelley, E. E., O'Doherty, R. M. Adipose Tissue Derived Free Fatty Acids Initiate Myeloid Cell Accumulation in Mouse Liver in States of Lipid Oversupply. Am J Physiol Endocrinol Metab. 2018; Epub ahead of print.
van der Windt, D. J., Sud, V., Zhang, H., Varley, P. R., Goswami, J., Yazdani, H. O., Tohme, S., Loughran, P., O'Doherty, R. M., Minervini, M. I., Huang, H., Simmons, R. L., Tsung, A. Neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in non-alcoholic steatohepatitis. Hepatology. 2018; Epub ahead of print.
Chartoumpekis, D. V., Yagishita, Y., Fazzari, M., Palliyaguru, D. L., Rao, U. N., Zaravinos, A., Khoo, N. K., Schopfer, F. J., Weiss, K. R., Michalopoulos, G. K., Sipula, I., O'Doherty, R. M., Kensler, T. W., Wakabyashi, N. Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice. JCI Insight. 2018; 3(5): pii:97735.
Chartoumpekis, D. V., Palliuaguru, D. L., Wakabayashi, N., Fazzari, M., Khoo, N. K., Schopfer, F. J., Sipula, I., Yagishita, Y., Michaelopoulos, G. K., O'Doherty, R. M., Kensler, T. W. Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice. Am J Physiol Endocrinol Metab. 2018; Epub ahead of print.
Liu, A., Chen, M., Kumar, R., Stefanovic-Racic, M., O'Doherty, R. M., Ding, Y., Jahnen-Dechent, W., Borghesi, L. Bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR4. Nat Commun. 2018; 9(1): 708.
Thapa, D., Zhang, M., Manning, J. R., Guimaraes, D., Stoner, M., O'Doherty, R. M., Shiva, S., Scott, I. Acetylation of mitochondrial proteins by GCN5L1 promotes enhanced fatty acid oxidation in the heart. Am J Physiol Heart Circ Physiol. 2017; Epub ahead of print.
Zhang, P., Chu, T., Dedousis, N., Mantell, B. S., Sipula, I., Li, L., Bunce, K. D., Shaw, P. A., Katz, L. S., Zhu, J., Argmann, C., O'Doherty, R. M., Peters, D. G., Scott, D. K. DNA methylation alters transcriptional rates of differentially expressed genes and contributes to pathophysiology in mice fed a high fat diet. Mol Metab. 2017; 6(4): 327-339.
Metlakunta, A., Huang, W., Sipula, I., Dedousis, N., Stefanovic-Racic, M., O'Doherty, R. M. Kupffer cells facilitate the acute effects of leptin on liver lipid metabolism. Am J Physiol Endocrinol Metab. 2017; 312(1): E11-E18.
Sponsored Research/Activities
Title: Research Training in Diabetes and Endocrinology
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: T32 DK007052
Start Year: 2016
End Year: 2021
Title: Research Training in Diabetes and Endocrinology
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: DK007052
Start Year: 2016
End Year: 2021
Title: Dendritic Cells and Obesity
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK102839
Start Year: 2015
End Year: 2019
Title: Myeloid FoxO1 in Lipid Metabolism
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK120310
Start Year: 2019
End Year: 2023
Title: Role of Fbxo48-mediated AMPK Proteostasis in the Pathogenesis and Treatment of NAFLD
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK119627
Start Year: 2019
End Year: 2023
Title: Allosteric Regulation of SIRT1 by a PACS-2 and DBC1 Regulatory Hub
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01
Start Year: 2019
End Year: 2020
Title: Obesity-Associated Mitophagy Resistance
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK114012
Start Year: 2018
End Year: 2023
Title: Mechanisms of Myocardial Infarction-Induced Insulin Resistance
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL143967
Start Year: 2018
End Year: 2023
Title: Regulation of Fuel Utilization by Lysine Acetylation in the Failing Heart
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL132917
Start Year: 2017
End Year: 2021
Title: Nitrite and Hypoxia Increases Biogenesis and Insulin Sensitivity
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL111706
Start Year: 2013
End Year: 2017
Notable Achievements
Editorial Board, American Journal of Physiology (Endo/Metabol), 2010-present