Department of Medicine
Faculty Profiles by Division

Division of Endocrinology and Metabolism

Faculty Profiles

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photo Yusuke Sekine, PhD

Assistant Professor of Medicine


Phone: 412-383-0698

Office: Bridgeside Point I - Room 567
100 Technology Dr.
Pittsburgh, PA 15219
Phone: 412-383-0698
Fax: 412-383-9055
Administrative Assistant:
Madi Henrie
Phone: 412-383-0483
Education and Training
BS, The University of Tokyo, 2005
MS, The University of Tokyo, 2007
PhD, The University of Tokyo, 2010
Postdoctoral Fellow, The University of Tokyo, 2010
Visiting Research Fellow, University of Cambridge, United Kingdom, 2013
Research Fellow, National Institutes of of Health, Bethesda, 2016
Research Interest
Dr. Sekine has been working on analyzing the moclecular mechanisms underlying cellular responses to a variety of stresses including oxidative stress, endoplasmic stress and metabolic stress. Using biochemical and cell genetic approaches, the Sekine lab is currently focusing on acetyl-CoA fluctuation-dependent functional changes of organelles (including nucleoli, mitochondria and lysosomes) and activation of organelle-associated stress signaling pathways. A long-term goal is to understand the sensing mechanisms of metabolite fluctuations in mammalian cells and reveal their relevance to human aging and age-associated diseases.
Selected Publications:
Zyryanova, A. F., Weis, F., Faille, A., Alard, A. A., Crespillo-Casado, A., Sekine, Y., Harding, H. P., Allen, F., Parts, L., Fromont, C., Fischer, P. M., Warren, A. J., Ron, D. Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B. Science. 2018; 359: 1533-1536.
Sekine, Y., Zyryanova, A., Crespillo-Casado, A., Amin-Wetzel, N., Harding, H. P., Ron, D. Paradoxical sensitivity to an integrated stress response blocking mutation in vanishing white matter cells. PLoS One. 2016; 11: e0166278.
Sekine, Y., Zyryanova, A., Crespillo-Casado, A., Fischer, P. M., Harding, H. P., Ron, D. Mutations in a translation initiation factor identify the target of a memory-enhancing compound. Science. 2015; 348: 1027-1030.
Halliday, M., Radford, H., Sekine, Y., Moreno, J., Verity, N., le Quesne, J., Ortori, C. A., Barrett, D. A., Fromont, C., Fischer, P. M., Harding, H. P., Ron, D., Mallucci, G. R. Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity. Cell Death Dis. 2015; 6: e1672.
Watanabe, T., Sekine, S., Naguro, I., Sekine, Y., Ichijo, H. Apoptosis Signal-regulating Kinase 1 (ASK1)-p38 pathway-dependent cytoplasmic translocation of the orphan nuclear receptor NR4A2 is required for oxidative stress-induced necrosis. J Biol Chem. 2015; 290: 10791-10803.
Mosallanejad, K., Sekine, Y., Ishikura-Kinoshita, S., Kumagai, K., Nagano, T., Matsuzawa, A., Takeda, K., Naguro, I., Ichijo, H. The DEAH-box RNA helicase DHX15 activates NF-kB and MAPK signaling downstream of MAVS during antiviral responses. Sci Signal. 2014; 7: ra40.
Sekine, Y., Hatanaka, R., Watanabe, T., Sono, N., Iemura, S., Natsume, T., Kuranaga, E., Miura, M., Takeda, K., Ichijo, H. The kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5. Mol Cell. 2012; 48: 692-704.
Ishida, Y., Sekine, Y., Oguchi, H., Chihara, T., Miura, M., Ichijo, H., Takeda, K. Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster. PLoS ONE. 2012; 7: e30265.
Sekine, Y., Takagahara, S., Hatanaka, R., Watanabe, T., Oguchi, H., Noguchi, T., Naguro, I., Kobayashi, K., Tsunoda, M., Funatsu, T., Nomura, H., Toyoda, T., Matsuki, N., Kuranaga, E., Miura, M., Takeda, K., Ichijo, H. p38 MAP kinase regulates the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors. J Cell Sci. 2011; 124: 3006-3016.