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Division of Endocrinology and Metabolism
Faculty Profiles
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Yong Wan, PhD
Endocrinology and Metabolism
Research Assistant Professor of Medicine
Email:
yow11@pitt.edu
Contact
Office:
Bridgeside Point I
100 Technology Drive
Pittsburgh, PA 15219
E-mail:
yow11@pitt.edu
Administrative Assistant:
Madi Henrie
Email:
mmh110@pitt.edu
Phone:
412-383-0483
Education and Training
Education
BS, Huazhong Agriculture University, China, 2006
PhD, Shanghai Jiao Tong University, China, 2013
Training
Postodctoral Associate, University of Pittsburgh, 2019
Research Interest
1. My primary research interest is to understand the molecular and cellular causes of aging-related bone disease - osteoporosis.
2. My sencondary research interest is focused on exploring the cellular, molecular and morphogenetic causes underlying the development of a new born bone disease - craniosynostosis (CS).
3. My third research interest is to evaluate the function of Wnt/Planar Cell Polarity (PCP) signal involved in a rare bone disease - autosomal-dominant Robinow syndrome (ADRS).
Publications
Selected Publications:
Wan, Y., Finkel, T. The mitochondria regulation of stem cell aging.
Mech Ageing Dev
. 2020; 191: 111334.
Wan Y, White C, Robert N, Rogers MB, Szabo-Rogers HL. Localization of Tfap2ß, Casq2, Penk, Zic1, and Zic3 Expression in the Developing Retina, Muscle, and Sclera of the Embryonic Mouse Eye.
The Journal of Histochemistry and Cytochemistry
. 2019; 67(12): 863-871.
Wan, Y., Lantz, B., Cusack, B. J., Szabo-Rogers, H. L. Prickle1 regulate differentiation of frontal bone osteoblasts.
Sci Rep
. 2018; 8(1): 18021.
Wan Y, Rogers MB, Szabo-Rogers HL. A six-gene expression toolbox for the glands, epithelium and chondrocytes in the mouse nasal cavity.
Gene Expression Pattern
. 2018; 27: 46-55.
Gibbs, B. C., Rao Damerla, R., Vladar, E. K., Chatterjee, B., Wan, Y., Liu, X., Cui, C., Gabriel, G. C., Zahid, M., Yahi, H., Szabo-Rogers, H. L., Suyama, K. L., Axelrod, J. D., Lo, C. W. Prickle1 mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects.
Biol Open
. 2016; 5(3): 323-35.
Zhao, H., Zhou, W., Yao, Z., Wan, Y., Cao, J., Zhang, L., Zhao, J., Li, H., Zhou, R., Li, B., Wei, G., Zhang, Z., French, C. A., Dekker, J. D., Yang, Y., Fisher, S. E., Tucker, H. O., Guo, X. Foxp1/2/4 regulate endochondral ossification as a suppresser complex.
Dev Biol
. 2014; 398(2): 242-254.
Wan, Y., Lu, C., Cao, J., Zhou, R., Yao, Y., Yu, J., Zhang, L., Zhao, H., Li, H., Zhao, J., Zhu, X., He, L., Liu, Y., Yao, Z., Yang, X., Guo, X. Osteoblastic Wnts differentially regulate bone remodeling and the maintenance of bone marrow mesenchymal stem cells.
Bone
. 2013; 55(1): 258-67.
Lu, C., Wan, Y., Cao, J., Zhu, X., Yu, J., Zhou, R., Yao, Y., Zhang, L., Zhao, H., Li, H., Zhao, J., He, L., Ma, G., Yang, X., Yao, Z., Guo, X. Wnt-mediated reciprocal regulation between cartilage and bone development during endochondral ossification.
Bone
. 2012; 53(2): 566-74.
Lantz B, White C, Liu X, Wan Y, Gabriel G, Lo CWY, Szabo-Rogers HL. Finding the Unicorn, a New Mouse Model of Midfacial Clefting.
Genes
. 2020; 11(1): 83.
Notable Achievements
Society of Developmental Biology Travel Award, 2019
Samuel and Emma Winters Foundation, 2021-2022
