Department of Medicine
Faculty Profiles by Division

Department of Medicine

Faculty Profiles

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photo Jonathan K. Alder, PhD

Pulmonary, Allergy and Critical Care Medicine

Assistant Professor of Medicine

Email: jalder@pitt.edu

Phone: 412-624-7441

Contact
Office: UPMC Montefiore Hospital
3459 Fifth Avenue, NW628
Pittsburgh, PA 15213
 
Phone: 412-624-7441
Fax: 412-624-1670
E-mail: jalder@pitt.edu
Administrative Assistant:
Jackie Harden
Address: UPMC Montefiore Hospital
3459 Fifth Avenue, NW628
Pittsburgh, PA 15213
Email: hardenja2@upmc.edu
Phone: 412-624-7441
Fax: 412-624-1670
Education and Training
Education
PhD, Cellular and Molecular Medicine, Johns Hopkins University, 2007
BA, Chemistry, University of Utah, 2005
Research Interest
My research focuses on understanding the role of telomere length in human health and disease. Telomeres are caps on the ends of each of chromosomes and shorten as we age. My current interest is exploring the mechanisms by which telomere dysfunction causes age-related lung diseases including pulmonary fibrosis and emphysema. Our lab uses a number of approaches to explore that pathogenesis of short-telomere mediated disease including genetics, cell biology, and animal models. We hope these studies will lead to a deeper understanding of how telomere dysfunction contributes to lung disease and potentially inform rational therapies.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Stanley, SE, Gable, DL, Wagner, CL, Carlile, TM, Hanumanthu, VS, Podlevsky, JD, Khalil, SE, DeZern, AE, Rojas-Duran, MF, Applegate, CD, et al. Loss-of-function mutations in the RNA biogenesis factor NAF1 predispose to pulmonary fibrosis-emphysema. Sci Transl Med. 2016; Aug 10;8: (351).
Alder, JK, Stanley, SE, Wagner, CL, Hamilton, M, Hanumanthu, VS, Armanios, M. Exome sequencing identifies mutant TINF2 in a family with pulmonary fibrosis. CHEST. 2015; May;147(5): 1361-1368.
Alder, JK, Chen, JJ, Lancaster, L, Danoff, S, Su, SC, Cogan, JD, Vulto, I, Xie, M, Qi, X, Tuder, RM, Phillips, JA 3rd, Lansdorp, PM, Loyd, JE, Armanios, MY. Short telomeres are a risk factor for idiopathic pulmonary fibrosis. Proc Natl Acad Sci U S A. 2008; Sep 2;105(35): 13051-6.
Alder, JK, Guo, N, Kembou, F, Parry, EM, Anderson, CJ, Gorgy, AI, Walsh, MF, Sussan, T, Biswal, S, Mitzner, W, Tuder, RM, Armanios, M. Telomere length is a determinant of emphysema susceptibility. Am J Respir Crit Care Med. 2011; Oct 15:184(8): 904-12.
Alder, JK, Parry, EM, Yegnasubramanian, S, Wagner, CL, Lieblich, LM, Auerbach, R, Auerbach, AD, Wheelan, SJ, Armanios, M. Telomere phenotypes in females with heterozygous mutations in the dyskeratosis congenita 1 (DKC1) gene. Hum Mutat. 2013; Nov;34(11): 1481-5.
Alder, JK, Barkauskas, CE, Limjunyawong, N, Stanley, SE, Kembou, F, Tuder, RM, Hogan, BL, Mitzner, W, Armanios, M. Telomere dysfunction causes alveolar stem cell failure. Proc Natl Acad Sci U S A. 2015; Apr 21;112(16): 5099-104.
Sponsored Research/Activities
Title: Mechanisms of Telomere-Mediated Lung Disease
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL135062
Start Year: 2018
End Year: 2023
Title: The Role of GDF15 in Lung Disease
Role: Principal Investigator
Funding Agency: Samuel and Emma Winters Foundation
Start Year: 2018
End Year: 2019
Title: Telomeres and Telomerase in Cancer
Role: Co-Investigator
Funding Agency: Johns Hopkins University
Grant Number: R35 CA209974
Start Year: 2017
End Year: 2017
Notable Achievements
Parker B. Francis Fellow, 2010