Department of Medicine
Faculty Profiles by Division

Department of Medicine

Faculty Profiles

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photo Christian Apetrei, MD, PhD

Infectious Diseases

Professor of Immunology

Professor of Infectious Diseases and Microbiology (School of Public Health)

Email: apetreic@pitt.edu

Phone: 412-383-5256

Contact
Office: 3550 Terrace Street
Scaife Hall 634
Pittsburgh, PA 15261
 
Phone: 412-383-5256
Fax: 412-648-8521
E-mail: apetreic@pitt.edu
Administrative Assistant:
Gabriella Merritt
Address: 3550 Terrace Street
Scaife Hall 817
Pittsburgh, PA 15261
Email: gmm76@pitt.edu
Phone: 412-383-9062
Fax: 412-648-8521
Education and Training
Education
MD, "Gr. T. Popa" School of Medicine, Iasi, Romania, 1990
PhD, "Gr. T. Popa" School of Medicine, Iasi, Romania, 1993
Training
Residency ID, "Gr. T. Popa" School of Medicine, Iasi, Romania, 1994
Postdoctoral-ANRS, "Bichat-Claude Bernard" Hospital, University Paris Diderot, Paris France, 1998
Research Interest
Dr. Apetrei’s Laboratory uses nonhuman primate models to address issues of simian immunodeficiency virus diversity and pathogenesis in natural hosts and upon cross-species transmission. Our overriding philosophy is that every aspect of HIV research can and should be modeled in appropriate animal models in order to understand the basic mechanisms that underlie disease processes and implement therapeutic approaches to control the deleterious consequences of HIV infection. Dr. Apetrei pioneered SIV pathogenesis in the wild and was actively involved during the last decades in modeling different aspects of HIV pathogenesis in nonhuman primate hosts. The current focus of his research is to assess the role of the gut dysfunction in the pathogenesis of HIV infection and to elaborate strategies to counter it in nonhuman primate models through multiple approaches. The lab is also involved in testing multiple approaches for cure research: virus reactivation with romidepsin, improvement of virus control and reactivation through regulatory T cells and the role of autovaccination in boosting an effective immune response that might lead to a functional cure of HIV. Dr. Apetrei is also involved in collaborative studies testing strategies to control chronic immune activation and prevent comorbidities in HIV-infected patients.
Sponsored Research/Activities
Title: New Strategy to Improve Gastrointestinal Health in SIV/HIV
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK119936
Start Year: 2019
End Year: 2020
Title: Tobacco Phase 17 Formula Funds
Role: Principal Investigator
Funding Agency: Commonwealth of Pennsylvania
Start Year: 2018
End Year: 2022
Title: Animal Model for Testing SIV Latency Reversal Strategies
Role: Principal Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R01
Start Year: 2015
End Year: 2020
Title: Assessing the role of GI tract damage to HIV/SIV disease progression
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01
Start Year: 2019
End Year: 2022
Title: Interventions to Reduce Hypercoagulability in Old SIV-Infected NHPs
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01
Start Year: 2019
End Year: 2020
Notable Achievements
Journal of Medical Primatology Editorial Board, 2005-Present
HIV Sequence Database Editorial Board, 2010-Present
JCI Insight Editorial Board, 2015-Present
Journal of Virology Editorial Board, 2017-Present
PLOS One Associate Editor, 2011-Present
Member AIDS Immunology and Pathogenesis (NHI), 2010-2014
Member CSS11 (Agence Francaise pour la Recherche sur le SIDA), 2013-Present
Member Horizon 20/20 (European Union), 2015, 2018, 2019
Member American Society for Immunology
Member American Association of Immunology