Department of Medicine
Faculty Profiles by Division

Department of Medicine

Faculty Profiles

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photo Gavin E. Arteel, PhD, FAASLD

Gastroenterology

Associate Chief for Basic Science

Pilot and Feasibility Core Director, Pittsburgh Liver Research Center

Email: gearteel@pitt.edu

Phone: 412-648-4187

Contact
Office: Thomas E. Starzl Biomedical Science Tower
200 Lothrop Street, West 1143
Pittsburgh, PA 15213
 
Phone: 412-648-4187
Fax: 412-648-4055
E-mail: gearteel@pitt.edu
Education and Training
Education
B.S., University of Wisconsin-Madison, 1993
Ph.D., University of North Carolina-Chapel Hill, 1997
Training
Postdoctoral fellow, Heinrich-Heine University, Duesseldorf, Germany, 1998
Postdoctoral fellow, University of North Carolina-Chapel Hill, 2000
Research Interest
Dr. Arteel’s research focuses on the interaction between hepatotoxicants (e.g., arsenic) and lifestyle choices (e.g., obesity and alcohol) in the initiation and progression of chronic liver diseases. His current research foci are based on the understanding that transitional changes to the ECM proteome (i.e., “matrisome”) play an underappreciated role in the initiation and progression of liver disease. He is developing computational tools to attempt to predict mechanism(s) and to develop biomarkers (or surrogate biomarkers) for use in the clinics.
Educational Interest
Dr. Arteel has been an active teacher for medical, graduate and dental students. He is also an active mentor/advisor for graduate students and post-doctoral fellows, having served as the primary advisor for over 25 graduate students and post-docs, plus serving on over 25 graduate student committees.
Publications
For my complete bibliography, Click Here.
Selected Publications:
McKim SE, Gäbele E, Isayama F, Lambert JC, Tucker LM, Wheeler MD, Connor HD, Mason RP, Doll MA, Hein DW, Arteel GE. Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice. Gastroenterology. 2003; 125: 1834-44.
Guo L, Richardson KS, Tucker LM, Doll MA, Hein DW, Arteel GE. Role of the renin-angiotensin system in hepatic ischemia reperfusion injury in rats. Hepatology. 2004; 40: 583-89.
Bergheim I, Guo L, Davis MA, Lambert JC, Beier JI, Duveau I, Luyendyk JP, Roth RA, Arteel GE. Metformin prevents alcohol-induced liver injury in the mouse: critical role of plasminogen activator inhibitor-1. Gastroenterology. 2006; 130: 2099-112.
Beier JI, Luyendyk JP, Guo L, von Montfort C, Arteel GE. Fibrin accumulation plays a critical role in the sensitization to lipopolysaccharide-induced liver injury caused by ethanol in mice. Hepatology. 2009; 49: 1545-53.
Beier JI, Jokinen JD, Holz GE, Whang PS, Martin AM, Warner NL, Arteel GE, Lukashevich IS. Novel Mechanism of Arenavirus-Induced Liver Pathology. PLoSOne. 2014; 10: e0122839.
Schreiter T, Sowa J-P, Schlattjan M, Treckmann J, Paul A, Strucksberg K-H, Baba HA, Odenthal M, Gieseler RK, Gerken G, Arteel GE, Canbay A. Human ex-vivo liver model for acetaminophen-induced liver damage. Scientific Reports. 2016; 6: 31916.
Poole LG, Dolin CE, Arteel GE. Organ-organ Crosstalk in Alcoholic Liver Disease. Biomolecules. 2017; 62: doi:10.3390/biom7030062.
Massey VL, Dolin CE, Poole LG, Hudson SV, Siow DL, Brock GN, Merchant ML, Wilkey DW, Arteel GE. The hepatic “matrisome” responds dynamically to injury: characterization of transitional changes to the extracellular matrix. Hepatology. 2017; 65: 969-82.
Hudson SV, Dolin CE, Poole LG, Massey VL, Wilkey D, Beier JI, Merchant ML, Frieboes HB, Arteel GE. Modeling the Kinetics of Integrin Receptor Binding to Hepatic Extracellular Matrix Proteins. Scientific Reports. 2017; 7: 12444.
You, M., Arteel, G.E. Effect of ethanol on lipid metabolism. Journal of Hepatology. 2018; 70(2): 237-248.
Sponsored Research/Activities
Title: Role of ECM and Inflammatory Remodeling in Alcohol-Induced Lever and Lung Damage
Role: Principal Investigator
Funding Agency: National Institute on Alcohol Abuse & Alcoholism
Grant Number: R01 AA021978
Start Year: 2018
End Year: 2020
Title: Role of Wnt/beta-catenin In Liver Regeneration
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01
Start Year: 2019
End Year: 2024
Notable Achievements
Member, Research Society on Alcoholism (RSoA), 2002-present
Member, Society of Toxicology (SOT), 2002-present
Member, American Association for the Study of Liver Diseases (AASLD), 2003-present
Member, XNDA study section, 2010-2014
Member, Editorial Board, Hepatology, 2006-present
Member, American Gastroenterological Society (AGA), 2010-present
Fellow of the American Association for the Study of Liver Diseases (FAASLD), 2015
Member and Chair, Basic Research Committee, American Association for the Study of Liver Diseases, 2015-2017
Chair, Hepatobiliary and Pathophysiology (HBPP) study section, 2018-present
UW-Madison Pharm/Tox Program Alumnus of the Year, 2019