Department of Medicine
Faculty Profiles by Division

Department of Medicine

Faculty Profiles

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photo David G. Binion, MD


Professor of Medicine

Co-Director, IBD Center - Translational Research

Director, Nutrition Support Service


Phone: 412-647-4194

Office: Division of Gastroenterology, Hepatology and Nutrition
UPMC Presbyterian Hospital M2, C Wing - 200 Lothrop St.
Pittsburgh, PA 15213
Phone: 412-647-4194
Fax: 412-648-9378
Administrative Assistant:
Clinical-Procedure Scheduling
Address: Division of Gastroenterology, Hepatology and Nutrition - IBD Center
200 Lothorp St. - UPMC Presbyterian - G-314
Pittsburgh, PA 15213
Phone: 412-647-2183
Fax: 412-864-1204
Education and Training
AB - General Studies, Harvard College - Cambridge, MA, 1984
MD, State Univ. of New York at Buffalo - Buffalo, NY, 1988
Research Fellow - Immunology, Cleveland Clinic Fdn. Research Inst. - Cleveland, OH, 1993
Internship & Residency, Rhode Island Hospital (Brown Univ.) - Providence, RI, 1991
Gastroenterology Fellowship, Univ. Hospitals of Cleveland (Case Western) - Cleveland, OH, 1993
Research Interest
Dr. David Binion is a Professor of Medicine and inflammatory bowel disease (IBD) investigator whose career has focused on defining the cellular and molecular mechanisms underlying human chronic gut inflammation and the translation of this knowledge into improved care for patients suffering from Crohn’s disease and ulcerative colitis. Current work has centered on Big Data analytics and the development and transformation of the UPMC IBD Registry, a prospective, multi-year, longitudinal natural history registry database of >3,000 consented IBD patients into a metadata platform for scientific discovery. Working in collaboration with computer scientists from the University of Pittsburgh School of Information Science, this relational database continuously curates and transforms observational clinical information from the electronic medical record (EMR) and maintains >10,000 person-years of associated metadata in a secure data warehouse. Areas of active investigation include:
• Developing prognostic biomarkers of IBD severity.
• Characterizing the impact of diet and nutrition on IBD natural history.
• Identification of biomarker patterns to predict development of dysplasia/cancer in IBD.
• Identification of predictive biomarkers to guide therapeutic selection in IBD.
• Comparative effectiveness studies in IBD maintenance therapy.
• Defining the impact of surgical anastomotic technique on longterm clinical outcomes in Crohn’s disease.
• Use of healthcare charge data as a comprehensive phenotype.
• Defining the impact of Clostridium difficile infection on IBD natural history.
• Characterizing extra-intestinal manifestations including anemia and autonomic dysfunction on the natural history of IBD.
• Developing clinical decision support tools to optimize IBD care and implement precision medicine.
Clinical Interest
Inflammatory bowel disease.
Nutrition support.
Intestinal transplantation.
For my complete bibliography, Click Here.
Selected Publications:
Regueiro, M., Kip, K.E., Schraut, W., Baidoo, L., Sepulveda, A.R., Pesci, M., El-Hachem, S., Harrison, J., Binion, D. Crohn's disease activity index does not correlate with endoscopic recurrence one year after ileocolonic resection. Inflammatory Bowel Diseases. 2011; 17(1): 118-26.
Barrie, A., Mourabet, M.E., Weyant, K., Clarke, K., Gajendran, M., Rivers, C., Park, S.Y., Hartman, D., Saul, M., Regueiro, M., Yadav, D., Binion, D.G. Recurrent blood eosinophilia in ulcerative colitis is associated with severe disease and primary sclerosing cholangitis. Digestive Diseases and Sciences. 2013; 58(1): 222-8.
Ramos-Rivers, C., Regueiro, M., Vargas, E.J., Szigethy, E., Schoen, R.E., Dunn, M., Watson, A.R., Schwartz, M., Swoger, J., Baidoo, L., Barrie, A., Dudekula, A., Youk, A.O., Binion, D.G. Association between telephone activity and features of patients with inflammatory bowel disease. Clinical Gastroenterology and Hepatology. 2014; 12(6): 986-94.
Koutroubakis, I.E., Regueiro, M., Schoen, R.E., Ramos-Rivers, C., Hashash, J.G., Schwartz, M., Swoger, J., Barrie, A., Baidoo, L., Dunn, M.A., Hartman, D., Binion, D.G. Multiyear Patterns of Serum Inflammatory Biomarkers and Risk of Colorectal Neoplasia in Patients with Ulcerative Colitis. Inflammatory Bowel Diseases. 2016; 22(1): 100-5.
Bhagya Rao, B., Koutroubakis, I.E., Ramos Rivers, C., Colombel, J.F., Regueiro, M., Swoger, J., Schwartz, M., Baidoo, L., Hashash, J., Barrie, A., Dunn, M.A., Binion, D.G. Delineation of Crohn's Disease Trajectories Using Change in Lemann Index: A Natural History Study. Journal of Clinical Gastroenterology. 2016; 50(6): 476-82.
Kabbani, T.A., Koutroubakis, I.E., Schoen, R.E., Ramos-Rivers, C., Shah, N., Swoger, J., Regueiro, M., Barrie, A., Schwartz, M., Hashash, J.G., Baidoo, L., Dunn, M.A., Binion, D.G. Association of Vitamin D Level with Clinical Status in Inflammatory Bowel Disease: A 5-Year Longitudinal Study. The American Journal of Gastroenterology. 2016; 111(5): 712-9.
Jiang, J., Click, B., Anderson, A.M., Koutroubakis, I.E., Rivers, C.R., Hashash, J.G., Dunn, M.A., Schwartz, M., Swoger, J., Barrie, A., Regueiro, M., Chang, C.C., Binion, D.G. Group-based Trajectory Modeling of Healthcare Financial Charges in Inflammatory Bowel Disease: A Comprehensive Phenotype. Clinical and Translational Gastroenterology. 2016; 7(7): e181.
Sponsored Research/Activities
Role: Principal Investigator
Funding Agency: Merck
Start Year: 2020
End Year: 2025
Title: Utilizing Clinical Metadata to Predict High-cost Complications and Treatment Response in IBD: Development of Clinical Decision Support Tools
Role: Principal Investigator
Funding Agency: Department of Defense
Start Year: 2017
End Year: 2020
Title: Early Treatment of Crohn's Disease (CD) Decrease Future Unplanned Healthcare Utilization
Role: Principal Investigator
Funding Agency: Abbvie. Inc.
Start Year: 2017
End Year: 2020
Title: Mitonuclear Communication During the Pathogenesis of Inflammatory Bowel Disease
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK120986
Start Year: 2020
End Year: 2024
Title: Mechanism of Systemic Inflammation-Associated Endothelial and Epithelial Cell Dysfunction Following Acute Pancreatitis, Trauma and Burns
Role: Co-Investigator
Funding Agency: Department of Defense
Grant Number: RES W81XWH-17-1-0502
Start Year: 2017
End Year: 2020
Notable Achievements
Fellow, American Gastroenterological Association, 2007
Sherman Prize Recipient, 2018
Pittsburgh Best Doctors 2021-22 (Pittsburgh Magazine & Castle Connolly), 2022
Excellence in Healthcare Honoree - WPA/WV Chapter, Crohn's & Colitis Foundation, 2022