Department of Medicine
Faculty Profiles by Division

Department of Medicine

Faculty Profiles

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photo Tomasz Brzoska, MPharm, PhD


Research Assistant Professor of Medicine


Office: Biomedical Science Tower
Pittsburgh, PA 15213
Education and Training
MPharm, Medical University of Bialystok, Poland, 2009
PhD, Hamamatsu University School of Medicine, Japan, 2013
Visiting Fellow Researcher, Jagiellonian Centre for Experimental Therapeutics, Poland, 2015
Postdoctoral Associate Associate, University of Pittsburgh School of Medicine, 2016
Selected Publications:
Dyer MR, Alexander W, Hassoune A, Chen Q, Brzoska T,, Alvikas J, Liu Y, Haldeman S, Plautz W, Loughran P, Li H, Boone B, Sadovsky Y, Sundd P, Zuckerbraun BS,, Neal MD. Platelet-derived extracellular vesicles released after trauma promote hemostasis and contribute to DVT in mice. The Journal of Thrombosis and Haemostasis. 2019; Oct;17(10): 1733-1745.
Vats R, Brzoska T, Bennewitz MF, Montanez MA, Tutuncuoglu E, Jonassaint J, Gutierrez E,, Watkins SC, Shiva S, Scott M, Morelli AE, Neal MD, Kato GJ, Gladwin MT, Sundd P. Platelet extracellular vesicles drive inflammasome-IL1ß-dependent lung injury in Sickle Cell Disease. American Journal of Respiratory and Critical Care Medicine. 2019; Sep 9.: 10.1164/rccm.201807-1370OC.
Li ZG, Scott MJ, Brzoska T, Sundd P, Li YH, Billiar TR, Wilson MA, Wang P, Fan J:. Lung epithelial cell-derived IL-25 negatively regulates LPS-induced exosome release from macrophages. Military Medical Research. 2018; Jul 30;: 5(1):24.
Brzoska T,, Suzuki Y, Sano H, Tomczyk M,, Tanaka H, Urano T:. Imaging analyses of coagulation-dependent initiation of fibrinolysis on activated platelets and its modification by TAFI. Thrombosis and Haemostasis. 2017; Apr 3;117(4): 682-690.
Suzuki Y, Sano H, Tomczyk M, Brzoska T, Urano T. Activities of wild-type and variant tissue-type plasminogen activators retained on vascular endothelial cells. Federation of European Biochemical Societies Open Bio FEBS Open Bio. 2016; Apr 1;6(5): 469-76.
Tomczyk M, Suzuki Y,, Sano H, Brzoska T, Tanaka H, Urano T. Bidirectional functions of thrombin on fibrinolysis: Evidence of thrombin-dependent enhancement of fibrinolysis provided by spontaneous plasma clot lysis. Thrombosis Research. 2016; Jul;143: 28-33.
Brzoska T, Tanaka-Murakami A, Suzuki Y,, Sano H, Kanayama N, Urano T. Endogenously Generated Plasmin at Vascular Wall Injury Site Amplified the Lysine Binding Site-Dependent Plasminogen Accumulation in Microthrombi. PLoS ONE. Public Library of Science. 2015; 10(3): e0122196.
Brzoska T, Suzuki Y,, Mogami H,, Sano H,, Urano T. Binding of thrombin-activated platelets to a fibrin scaffold through aIIbß3 evokes phosphatidylserine exposure on their cell surface. PLoS ONE. 2013; 8(2),: e55466.
Kramkowski K, Leszczynska A, Mogielnicki A, Chlopicki S,, Fedorowicz A, Grochal E,, Mann B, Brzoska T,, Urano T,, Motterlini R, Buczko W. Antithrombotic properties of water-soluble carbon monoxide-releasing molecules. Arteriosclerosis, Thrombosis, and Vascular Biology. 2012; Sep;32(9): 2149-2157.
Suzuki Y,, Yasui H, Brzoska T,, Mogami H, Urano T. Surface-retained tPA is essential for effective fibrinolysis on vascular endothelial cells. Blood. 2011; Sep 15;118(11): 3182-3185.
Sponsored Research/Activities
Title: Pulmonary Arteriole Occlusion by Platelet-Neutrophil Micro-Emboli in Acute Chest Syndrome
Role: Post Doctoral Associate
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL128297
Start Year: 2015
End Year: 2021
Notable Achievements
Young Investigator Award - XXIII Congress of the International Society on Thrombosis and Haemostasis, 2011
Young Investigator Award - XXV Congress of the International Society on Thrombosis and Haemostasis, 2015
American Society of Hematology Abstract Achievement Award, 2017
American Thoracic Society Abstract Award- Dallas, 2019
American Society of Hematology Abstract Achievement Award- Florida, 2019