Department of Medicine
Faculty Profiles by Division

Department of Medicine

Faculty Profiles

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photo (Joyce) Chung-Chou H. Chang, PhD

General Internal Medicine

Professor of Medicine, Biostatistics, and Clinical and Translational Science

Email: changj@pitt.edu

Phone: 412-692-4868

Contact
Office: 200 Meyran Avenue
Suite 200
Pittsburgh, PA 15213
 
Phone: 412-692-4868
Fax: 412-246-6954
E-mail: changj@pitt.edu
Education and Training
Education
MA in Mathematical Statistics, University of Pittsburgh, 1992
PhD in Biostatistics, University of Pittsburgh, 1998
Research Interest
Dr. Chang has a wide range of interests in theoretical and applied statistics, including time-to-event (survival) and longitudinal data analysis, missing data (competing risks and informative dropout), causal effect modeling (propensity score and marginal structural modeling), design and analysis of observational studies and clinical trials, design and analysis of studies of biomarkers in risk prediction, dynamic prediction, and machine learning techniques. She has served as the lead statistician on numerous research projects and has been the consulting statistician for several K-award projects. In these roles, she has helped investigators throughout the University develop new research protocols and data analysis plans for a wide range of biomedical studies and has overseen the data management and analyses of these studies.

Rather than limiting her role to applying traditional statistical methodology to projects, Dr. Chang actively encourages and promotes the use of the most up-to-date appropriate statistical methods. She has applied these methods to a wide range of investigations, including research on aging, HIV/AIDS and other infectious diseases, heart diseases, liver transplantation, health services research, and acute illness.
Publications
For my complete bibliography, Click Here.
Sponsored Research/Activities
Title: Clinical and Genetic Determinants of Peripheral Artery Disease, Microvascular Disease, and Major Adverse Limb Outcomes
Role: Principal Investigator
Funding Agency: Vanderbilt University
Grant Number: RES 18SFRN33900069
Start Year: 2018
End Year: 2022
Title: 5/6 COMpAAAS U24: Resource in Informatics and Biostatistics (RIB)
Role: Principal Investigator
Funding Agency: Yale University
Grant Number: U24 AA022001
Start Year: 2016
End Year: 2021
Title: Immune Function and the Risk of CVD Among HIV Infected and Uninfected Veterans
Role: Principal Investigator
Funding Agency: Vanderbilt University
Grant Number: R01 HL125032
Start Year: 2014
End Year: 2017
Title: Temporally-Oriented Subjective Well-being Across Transitions - Resources & Outcomes
Role: Principal Investigator
Funding Agency: University of Utah/National Center for Complementary/Alternative Medicine
Grant Number: R01 AT007262
Start Year: 2014
End Year: 2016
Title: Cardiovascular Disease Study Researching CVD and Other Comorbid Conditions Associated with HIV Infection
Role: Principal Investigator
Funding Agency: Vanderbilt University
Start Year: 2014
End Year: 2015
Title: The NICU Antibiotics and Outcomes (NANO) Trial
Role: Co-Investigator
Funding Agency: National Institute of Health
Grant Number: R01
Start Year: 2019
End Year: 2024
Title: Organizational Strategies for Improving Evidence-Uptake in Intensive Care
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R35 HL144804
Start Year: 2019
End Year: 2023
Title: Clinical, Genetic, and Proteomic Risk Factors for Pulmonary Hypertension in Heart Failure
Role: Co-Investigator
Funding Agency: Vanderbilt University/ National Heart, Lung, & Blood Institute
Grant Number: R01
Start Year: 2019
End Year: 2023
Title: Autonomous Diagnosis and Management of the Critically Ill During Air Transport (ADMIT)
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL141916
Start Year: 2019
End Year: 2023
Title: Examining the Quality of Opioid Use Disorder Treatment in a Medicaid Research Network
Role: Co-Investigator
Funding Agency: National Agency for Drug Abuse
Grant Number: R01 DA048029
Start Year: 2019
End Year: 2021
Title: Risk Factors for MCI and Dementia in a Diverse Senior Cohort
Role: Co-Investigator
Funding Agency: National Institute of Aging
Grant Number: R01 AG058549
Start Year: 2018
End Year: 2023
Title: Educational strategies to promote post-extubation non-invasive ventilation in patients with acute respiratory failure
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: U01 HL143507
Start Year: 2018
End Year: 2020
Title: Risk of long-term opioid use and its sequelae due to opioid prescribing for acute pain
Role: Co-Investigator
Funding Agency: Benter Foundation
Start Year: 2018
End Year: 2020
Title: Population Health Management to Optimize Care for Patients with High Risk Chronic Kidney Disease
Role: Co-Investigator
Funding Agency: Vanderbilt University
Grant Number: R01 DK116957
Start Year: 2018
End Year: 2019
Title: Increasing Equity in Transplant Evaluation and Living Donor Kidney Transplantation
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK101715
Start Year: 2018
End Year: 2019
Title: Optimizing Pediatric Subspecialty Care Through Telemedicine and e-Consultations
Role: Co-Investigator
Funding Agency: National Institute of Child Health & Human Development
Grant Number: K23 HD088642
Start Year: 2017
End Year: 2022
Title: PReCISE AKI (Phenotyping Renal Cases in Sepsis and Surgery for Early Acute Kidney Injury)
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: UG3 DK114861
Start Year: 2017
End Year: 2022
Title: The Effects of State Sepsis Mandates on Hospital Mortality, Health Care Utilization and Costs
Role: Co-Investigator
Funding Agency: Agency for Healthcare Research and Quality
Grant Number: R01 HS025146
Start Year: 2017
End Year: 2021
Title: Mild Cognitive Impairment: A Prospective Community Study
Role: Co-Investigator
Funding Agency: National Institute of Aging
Grant Number: R01 AG023651
Start Year: 2016
End Year: 2021
Title: University of Pittsburgh Clinical and Translational Science Institute (Team Science)
Role: Co-Investigator
Funding Agency: National Center for Advancing Translational Sciences
Grant Number: UL1 TR001857
Start Year: 2016
End Year: 2021
Title: Sepsis Endotyping Using Clinical and Biological Data
Role: Co-Investigator
Funding Agency: National Institute of General Medical Science
Grant Number: R35 GM119519
Start Year: 2016
End Year: 2021
Title: University of Pittsburgh Clinical and Translational Science Institute (Workplace Development)
Role: Co-Investigator
Funding Agency: National Center for Advancing Translational Sciences
Grant Number: UL1 TR001857
Start Year: 2016
End Year: 2021
Title: Enhancing the Access and Quality of Medication-Assisted Treatment (MAT) for Individuals with Opioid Use Disorder (OUD) in Rural Pennsylvania's Medicaid Primary Care Practices
Role: Co-Investigator
Funding Agency: Commonwealth of Pennsylvania
Grant Number: R18 HS025072
Start Year: 2016
End Year: 2019
Title: Real-Time Detection of Deviations in Clinical Care in ICU Data Stream
Role: Co-Investigator
Funding Agency: National Institute of General Medical Science
Grant Number: R01 GM088224
Start Year: 2016
End Year: 2017
Title: Novel Approaches to Profiling Hospitals on Critical Illness Mortality
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL126694
Start Year: 2015
End Year: 2018
Title: Natural History of Clostridium Difficile Infection In Inflammatory Bowel Disease Patients
Role: Co-Investigator
Funding Agency: Cubist Pharmaceuticals
Start Year: 2015
End Year: 2016
Title: Predictors of Treatment Outcomes for Crohns Disease
Role: Co-Investigator
Funding Agency: UCB, Inc.
Start Year: 2015
End Year: 2016
Title: Innate and Adaptive Immunity in HIV-Associated Impaired Glucose Tolerance and Diabetes
Role: Co-Investigator
Funding Agency: Vanderbilt University/National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R56 DK108352
Start Year: 2015
End Year: 2016
Title: Increasing Equity in Transplant Evaluation and Living Donor Kidney Transplantation
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK101715
Start Year: 2014
End Year: 2019
Title: A Stepped Wedge Trial of an Intervention to Support Family Members in ICUs
Role: Co-Investigator
Funding Agency: National Institute of Nursing Research
Grant Number: R01 NR014663
Start Year: 2014
End Year: 2019
Title: Procalcitonin Antibiotic Consensus Trial (ProACT)
Role: Co-Investigator
Funding Agency: National Institute of General Medical Science
Grant Number: R01 GM097471
Start Year: 2014
End Year: 2018
Title: HIV, Depression, and Cardiovascular Risk
Role: Co-Investigator
Funding Agency: Indiana University/National Heart, Lung, & Blood Institute
Grant Number: R01 HL126557
Start Year: 2014
End Year: 2018
Title: Identifying Optimal Care Structures and Processes in Long Term Acute Hospitals
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL096651
Start Year: 2014
End Year: 2018
Title: Modeling Strategies for Observational CER - What Works Best When?
Role: Co-Investigator
Funding Agency: Patient-Centered Outcomes Research Institute
Start Year: 2014
End Year: 2017
Title: Immune Function and the Risk of CVD Among HIV Infected and Uninfected Veterans
Role: Co-Investigator
Funding Agency: Vanderbilt University/National Heart, Lung, & Blood Institute
Grant Number: R01 HL125032
Start Year: 2014
End Year: 2017
Title: Late Cardiovascular Consequences of Septic Shock
Role: Co-Investigator
Funding Agency: National Institute of General Medical Science
Grant Number: R01 GM097471
Start Year: 2014
End Year: 2017
Title: Cardiac Pathology and Risk Prediction for Sudden Cardiac Death in Patients with HIV
Role: Co-Investigator
Funding Agency: Vanderbilt University/University of California - San Francisco
Grant Number: R01 HL126555
Start Year: 2014
End Year: 2016
Title: Identifying Effective Strategies to Disclose Prognosis in Patients with ARDS
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL094553
Start Year: 2014
End Year: 2015
Title: The Role of Physician Networks in the Adoption of New Prescription Drugs
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL119246
Start Year: 2013
End Year: 2017
Title: University of Pittsburgh Clinical and Translational Science Institute - Research Education Core
Role: Co-Investigator
Funding Agency: National Center for Advancing Translational Sciences
Grant Number: UL1 TR000005
Start Year: 2011
End Year: 2016
Title: Consortium to Improve Outcomes in HIV/AIDS, Alcohol, Aging, & Multi-Substance Use
Role: Co-Investigator
Funding Agency: Yale University/National Institute on Alcohol Abuse & Alcoholism
Grant Number: U24 AA020794
Start Year: 2011
End Year: 2016
Title: Vascular Subphenotypes of Lung Disease - Core C
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: P01 HL103455
Start Year: 2011
End Year: 2016
Title: Cardiovascular Disease Mechanisms in HIV Infected and Uninfected Veterans
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL095136
Start Year: 2011
End Year: 2015
Title: A Multi-Center Group to Study Acute Liver Failure in Children
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: U01 DK072146
Start Year: 2011
End Year: 2015
Title: Mild Cognitive Impairment: A Prospective Community Study
Role: Co-Investigator
Funding Agency: National Institute of Aging
Grant Number: R01 AG023651
Start Year: 2010
End Year: 2015
Notable Achievements
Member, American Statistical Association, 1990-present
Member, International Biometric Society, Eastern North American Region, 1995-present
Member, International Society for Clinical Biostatistics, 2002-present
Member, Society for Clinical and Translational Science, 2009-present
Distinguished Alumni Award for Teaching and Dissemination, presented by the Graduate School of Public Health (GSPH), University of Pittsburgh, 2014
Member, American Academy of Master Educators (AME), School of Medicine, University of Pittsburgh, 2015-2020
Statistician of the Year, presented by the American Statistical Association Pittsburgh Chapter, 2016