Department of Medicine
Faculty Profiles by Division

Department of Medicine

Faculty Profiles

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photo Zhangguo Chen, PhD


Research Associate Professor of Medicine


Phone: 412-623-4674

Office: UPMC Hillman Cancer Center Research Pavilion
5117 Centre Ave, Suite 1.16
Pittsburgh, PA 15213
Phone: 412-623-4674
Education and Training
BS, Hengyang Medical College, Hunan, China, 1983
MS, Shanghai Medical University, Shanghai, China, 1989
PhD, Beijing Medical University, Beijing, China., 1997
Postdoc, Ohio State University, Columbus, OH, 1999
Postdoctoral Fellow, Sherbrooke University, Quebec, Canada., 2003
Research Interest
My research interests include three topics: (1) elucidate the basic mechanisms of antibody gene diversification including how B cells undergo class switch recombination and how B cell receptor (BCR) signaling connects autoimmunity and B cell lymphomagenesis; (2) define signaling adaptors as non-classical checkpoints that contribute to the maintenance of B cell genome; and (3) cancer immunology and immunotherapy with a focus on B cell lymphoma and head and neck cancer.