Department of Medicine
Faculty Profiles by Division

Department of Medicine

Faculty Profiles

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photo Sudipta Das, PhD

Pulmonary, Allergy and Critical Care Medicine

Research Assistant Professor of Medicine


Phone: 412-692-2210

Office: UPMC Montefiore, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
Phone: 412-692-2210
Fax: 412-692-2260
Administrative Assistant:
Patty Geraci
Phone: 412-692-2118
Fax: 412-692-2260
Education and Training
BS-Zoology, University of Calcutta, Kolkata, India, 2005
MS-Biochemistry, Jiwaji University, Gwalior, India, 2007
PhD-Biochemistry, Jagiellonian University, Krakow, Poland, 2012
Research Interest
Dr. Das is interested primarily in two areas, which are immunoregulatory mechanisms that mediate response to respiratory pathogens and mechanisms that prevent lung epithelial damage and injury during infections and those that protect from epithelial damage. Her early work primarily focused on understanding the molecular and immunological mechanisms that underlie severe illness in children infected by respiratory syncytial virus (RSV). She identified a pathogenic role for ?d T cells in the context of specific immune deficiencies of CX3CR1 due to RSV infection in early life. She showed that the lungs of CX3CR1-deficient mice expressed higher level of IL-1ß, which is a potent inducer of IL-17 in ?d T cells driving their accumulation post infection. In related studies she discovered the ability of the cytokine IL-22 to reduce viral titer in infected primary human airway epithelial cells and also in the lungs of newborn mice with cellular autophagy playing a role in the interplay between RSV and IL-22.
Her current research is focused on host immune responses to pulmonary bacterial infections. Using scRNA-seq approaches a novel gene signature was identified in the peripheral blood mononuclear cells (PBMCs) of subjects with sepsis and ARDS as compared to that in cells of patients with sepsis only. Her ongoing research with Pseudomonas and Klebsiella infection models is directed towards understanding of diverse host response specific to the pathogen and the role of innate immune cells in resolution of lung inflammation and clearance of bacteria.
Selected Publications:
Gauthier M, Kale SL, Oriss TB, Scholl K, Das S, Yuan H, Hu S, Chen J, Camiolo M, Ray P, Wenzel S, Ray A. Dual role for CXCR3 and CCR5 in asthmatic type 1 inflammation. J Allergy Clin Immunol. 2022; Jan;149(1): 113-124.e7.
Yuan H, Chen J, Hu S, Oriss TB, Kale SL, Das S, Nouraie SM, Ray P, Ray A. Early life exposure to house dust mite allergen prevents experimental allergic asthma requiring mitochondrial H2O2. Mucosal Immunol. 2022; Jan;15(1): 154-164.
Das S, St. Croix C, Good M, Chen J, Zhao J, Hu S, Ross M, Myerburg MM, Pilewski JM, Williams J, Wenzel SE, Kolls JK, Ray A, Ray P. Interleukin-22 Inhibits Respiratory Syncytial Virus Production by Blocking Virus-Mediated Subversion of Cellular Autophagy. iScience. 2020; Jul 24;23(7): 101256.
Jiang Y, Rosborough BR, Chen J, Das S, Kitsios GD, McVerry BJ, Mallampalli RK, Lee JS, Ray A, Chen W, Ray P. Single cell RNA sequencing identifies an early monocyte gene signature in acute respiratory distress syndrome. JCI Insight. 2020; Jul 9;5(13): e135678.
Das S, Raundhal M, Chen J, Oriss TB, Huff R, Williams JV, Ray A, Ray P. Respiratory syncytial virus infection of newborn CX3CR1-deficient mice induces a pathogenic pulmonary innate immune response. JCI Insight. 2017; Sep 7;2(17): e94605.
Gauthier M, Chakraborty K, Oriss TB, Raundhal M, Das S, Chen J, Huff R, Sinha A, Fajt M, Ray P, Wenzel SE, Ray A. Severe asthma in humans and mouse model suggests a CXCL10 signature underlies corticosteroid-resistant Th1 bias. JCI Insight. 2017; Jul 6;2(13): e94580.
Oriss TB, Raundhal M, Morse C, Huff RE, Das S, Hannum R, Gauthier MC, Scholl KL, Chakraborty K, Nouraie SM, Wenzel SE, Ray P, Ray A. IRF5 distinguishes severe asthma in humans and drives Th1 phenotype and airway hyperreactivity in mice. JCI Insight. 2017; May 18;2(10): e91019.
Khare A, Raundhal M, Chakraborty K, Das S, Corey C, Kamga CK, Quesnelle K, St. Croix C, Watkins SC, Morse C, Oriss TB, Huff R, Hannum R, Ray P, Shiva S, Ray A. Mitochondrial H2O2 in Lung Antigen-Presenting Cells Blocks NF-?B Activation to Prevent Unwarranted Immune Activation. Cell Rep. 2016; May 24;15(8): 1700-14.
Zou C, Synan MJ, Li J, Xiong S, Manni ML, Liu Y, Chen BB, Zhao Y, Shiva S, Tyurina YY, Jian J, Lee JS, Das S, Ray A, Ray P, Kagan VE, Mallampalli RK. LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1. J Cell Sci. 2016; Jan 1;129(1): 51-64.
Das S, Czarnek M, Bzowska M, Mezyk-Kopec R, Stalinska K, Wyroba B, et al. ADAM17 Silencing in Mouse Colon Carcinoma Cells: The Effect on Tumoricidal Cytokines and Angiogenesis. PLoS ONE. 2012; 7(12): e50791.
Notable Achievements
Immunology 2020: AAI Annual Meeting - abstract award, 2020
Immunology 2016: AAI Annual Meeting - poster award, 2016