Department of Medicine
Faculty Profiles by Division

Department of Medicine

Faculty Profiles

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photo Toren Finkel, MD, PhD

Cardiology

Professor of Medicine, Division of Cardiology

G. Nicholas Beckwith III and Dorothy B. Beckwith Chair in Translational Medicine

Director, Aging Institute of UPMC and Pitt

Email: finkelt@pitt.edu

Phone: 412-383-4409

Contact
Office: 555 Bridgeside Point I
100 Technology Drive
Pittsburgh, PA 15219
 
Phone: 412-383-4409
Fax: 412-383-9055
E-mail: finkelt@pitt.edu
Administrative Assistant:
Kathy Brickett
Address: 571.1 Bridgeside Point I
100 Technology Drive
Pittsburgh, PA 15219
Email: kab389@pitt.edu
Phone: 412-383-4416
Fax: 412-383-9055
Education and Training
Education
MD, Harvard Medical School, 1986
PhD, Biophysics, Harvard University School of Arts & Sciences, 1986
BS, Physics, University of Maryland, 1979
Training
Fellowship in Cardiology, Johns Hopkins Hospital, 1992
Internship and Residency in Internal Medicine, Massachusetts General Hospital, 1989
Research Interest
Dr. Finkel's lab is interested in the intersection of metabolism, mitochondrial function and aging. Current projects include the link between impaired autophagy and vascular aging, the molecular basis that regulates mitochondrial calcium entry, the role of fatty acid oxidation in regulating cell fate and the molecular control on mitochondrial turnover.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Sun N, Malide D, Liu J, Rovira II, Combs CA, Finkel T. A fluorescence-based imaging method to measure in vitro and in vivo mitophagy using mt-Keima. Nature Protocols. 2017; 12(8): 1576-1587.
Pan H, Yan Y, Liu C, Finkel T. The role of ZKSCAN3 in the transcriptional regulation of autophagy. Autophagy. 2017; 13(7): 1235-1238.
Liu JC, Parks RJ, Liu J, Stares J, Rovira II, Murphy E, Finkel T. The In Vivo Biology of the Mitochondrial Calcium Uniporter. Advances in Experimental Biology and Medicine. 2017; 982: 49-63.
Sponsored Research/Activities
Title: The Role of Calcium Entry Through the Mitochondrial Uniporter in Regulating Cardiac Metabolism and Physiology
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL142589
Start Year: 2019
End Year: 2023
Title: Vascular Autophagy as a Mediator of Vascular Aging and Homeostasis
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL142663
Start Year: 2018
End Year: 2022
Title: Vascular Autophagy and HGPS Progression
Role: Principal Investigator
Funding Agency: Progeria Research Foundation
Start Year: 2017
End Year: 2020
Title: Vascular Autophagy and HGPS Pprogression
Role: Principal Investigator
Funding Agency: Leducq Foundation
Start Year: 2017
End Year: 2018
Title: DCAF7/HDAC4/TFEB Axis in Acute Lung Injury
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL142777
Start Year: 2018
End Year: 2023
Title: Pittsburgh Older Americans Independence Center
Role: Core Leader
Funding Agency: National Institute of Aging
Grant Number: P30 AG024827
Start Year: 2017
End Year: 2020
Notable Achievements
NHLBI Orloff Innovation Award, 2016
NHLBI Director's Award-Outstanding Translational Science, 2015
Fellow, American Association for the Advancement of Science, 2013
Association of American Physicians, 2009
Ellison Medical Foundation Senior Scholar in Aging Award, 2006-2010
American Society for Clinical Research, 2002