Department of Medicine
Faculty Profiles by Division

Department of Medicine

Faculty Profiles

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photo Aditi U. Gurkar, PhD


Assistant Professor of Medicine, Division of Geriatric Medicine, Aging Institute


Phone: 412-624-7494

Office: 563 Bridgeside Point I
100 Technology Drive
Pittsburgh, 15219
Phone: 412-624-7494
Fax: 412-383-9055
Administrative Assistant:
Andrea Radziminski
Address: 571,1 Bridgeside Point I
100 Technology Drive
Pittsburgh, PA 15219
Phone: 412-383-0843
Fax: 412-383-9055
Education and Training
•PhD, Boston University, School of Medicine, 2009
•B.S., University of South Florida, Tampa/Florida International University, 2006
•Post-Doctorate, The Scripps Research Institute/Harvard Medical School/MGH/Broad Insitute
Research Interest
An Assistant Professor of Medicine, Dr. Gurkar’s interest is in understanding the biology of aging and age-related diseases. Her NIH-funded research focuses on identifying the signaling mechanisms that drive aging in response to endogenous DNA damage. By defining these molecular mechanism(s), she hopes to identify novel therapeutic targets that can be exploited to extend healthspan.
Selected Publications:
Hamsanathan, S., Anthonymuthu, T., Mullett, S.J., Wendell, S.G., Han, S., Shinglot, H., Siefken, E., Sims, A., Sen, P., Pepper, H.L., Snyder, N.W., Bayir, H., Kagan, V., Gurkar, A.U. Persistent DNA damage rewires lipid metabolism and promotes histone hyperacetylation via MYS-1/Tip60. Biorxiv. 2021.
Hamsanathan, S., Anthonymuthu, T., Prosser, D., Lokshin, A., Greenspan, S.L., Resnick, N.M., Perera, S., Narasimhan, G., Gurkar, A.U. A Molecular Index for Biological Age identified from the Metabolome and Senescence-associated Secretome in Humans. Research Square. 2020.
Gurkar, A.U., Robinson, A.R., Cui, Y., Li, X., Webster, A., Muravia, M., Fallahi, M., Weissbach, H., Robbins, P.D., Wang, Y., Kelley, E.E., Croix, C.M.S., Niedernhofer, L.J., Gill, M.S. Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging. Redox Biology. 2018; 18: 191-199.
Niedernhofer, L.J., Gurkar, A.U., Wang, Y., Vijg, J., Hoeijmakers, J.H.J., Robbins, P.D. Nuclear Genomic Instability and Aging. Annual Review of Biochemistry. 2018; 87: 295-322.
Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A.C., Ding, H., Giorgadze, N., Palmer, A.K., Ikeno, Y., Hubbard, G.B., Lenburg, M., O'Hara, S.P., LaRusso, N.F., Miller, J.D., Roos, C.M., Verzosa, G.C., LeBrasseur, N.E., Wren, J.D., Farr, J.N., Khosla, S., Stout, M.B., McGowan, S.J., Fuhrmann-Stroissnigg, H., Gurkar, A.U., Zhao, J., Colangelo, D. The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell. 2015; 14(4): 644-658.
Sponsored Research/Activities
Title: Examing the spatio temporal role of oxidative telomere damage on healthspan and lifespan of optogenetics
Role: Principal Investigator
Funding Agency: Aging Institute of UPMC
Start Year: 2018
End Year: 2019
Title: Modulators of DNA Damage Associated Nucleo-Mitochondrial Communication in Aging
Role: Principal Investigator
Funding Agency: National Institute of Aging
Grant Number: R00 AG049126
Start Year: 2017
End Year: 2020
Title: Pittsburgh Older Americans Independence Center
Role: Co-Investigator
Funding Agency: National Institute of Aging
Grant Number: P30 AG024827
Start Year: 2020
End Year: 2021
Notable Achievements
•Co-Editor, Special Issue C. elegans, Automation, Machine learning and AI. Frontiers in Aging, 2022
•Ad-hoc Reviewer, National Science Foundation, 2022
•Ad-hoc Reviewer, ZAG1 ZIJ-R J3 study section, NIH, 2021
•Ad-hoc Reviewer, CMAD study section NIH, 2021
•Ad-hoc Reviewer, Inspire Grants to Develop Geroscience Research Programs, 2020
•Ad-hoc Reviewer, Kansas IDeA Network of Biomedical Research Excellence (K-INBRE), 2020
•Finding Genius Podcast: Molecular Mechanisms of Aging, 2020
•Ad-hoc Grant Reviewer, The Dutch Research Council (NOW), 2020
•TEDxPittsburgh: Brilliant and Bold Women, 2019
•First prize- Bench Junior Faculty, Aging Institute Research Day, University of Pittsburgh, 2018