Department of Medicine
Faculty Profiles by Division

Department of Medicine

Faculty Profiles
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photo Nadine Hempel, PhD

Hematology/Oncology

Associate Professor of Medicine, Division of Hematology/Oncology

Vice Chief for Basic Research, Division of Hematology/Oncology

Faculty Member, Cancer Biology Program & Women's Cancer Research Center, UPMC Hillman Cancer Center

Email: nah158@pitt.edu

Phone: 412-648-4822
Contact
Office: UPMC Hillman Cancer Center - The Assembly
5051 Centre Ave
Pittsburgh, PA 15213
 
Phone: 412-648-4822
Fax:
E-mail: nah158@pitt.edu
Administrative Assistant:
Eli Coutch
Address: UPMC Hillman Cancer Center
The Assembly, Suite 2049
Pittsburgh, PA 15213
Email: coutche@upmc.edu
Phone: 412-648-5015
Administrative Assistant:
Ken Koncerak
Address: UPMC Hillman Cancer Center
The Assembly, Suite 2049
Pittsburgh, PA 15213
Email: koncerakk@upmc.edu
Phone: 412-624-8722
Education and Training
Education
BSc (Hons), University of Queensland, 1999
PhD, University of Queensland, 2004
Training
Post-doctoral Fellow, Duke University Medical Center, 2007
Post-doctoral Fellow, Albany Medical College, 2011
Research Interest
Dr. Nadine Hempel's research interests center on understanding molecular mechanisms that regulate metastasis and tumor recurrence of ovarian cancer, with the ultimate goal of identifying novel targets for therapy of advanced-stage disease.

Her research group uses a variety of molecular, cellular, imaging and in vivo techniques to focus on two research areas in cancer biology: first, the role of mitochondrial antioxidants and reactive oxygen species during metastatic progression; and second, the regulation of mitochondrial dynamics and metabolism in ovarian cancer.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Kim YS, Tang PW, Welles JE, Pan W, Javed Z, Elhaw AT, Mythreye K, Kimball SR, Hempel N. HuR-dependent SOD2 protein synthesis is an early adaptation to anchorage-independence. Redox Biology. 2022; 53: 102329.
Shonibare Z, Monavarian M, O'Connell K, Altomare D, Shelton A, Mehta S, Jaskula-Sztul R, Phaeton R, Starr MD, Whitaker R, Berchuck A, Nixon AB, Arend RC, Lee NY, Miller CR, Hempel N, Mythreye K. Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer. Cell Reports. 2022; 40: 111066.
Kim YS, Gupta Vallur P, Jones VM, Worley BL, Shimko S, Shin DH, Crawford LC, Chen CW, Aird KM, Abraham T, Shepherd TG, Warrick JI, Lee NY, Phaeton R, Mythreye K, Hempel N. Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells. Oncogene. 2020; 39(8): 1619-1633.
Pathak T, Gueguinou M, Walter V, Delierneux C, Johnson MT, Zhang X, Xin P, Yoast RE, Emrich SM, Yochum GS, Sekler I, Koltun WA, Gill DL, Hempel N, Trebak M. Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis. Elife. 2020; 9: e59686.
Worley BL, Kim YS, Mardini J, Zaman R, Leon KE, Vallur PG, Nduwumwami A, Warrick JI, Timmins PF, Kesterson JP, Phaëton R, Lee NY, Walter V, Endres L, Mythreye K, Aird KM, Hempel N. GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment. Redox Biology. 2019; 25: 101051.
Hempel N, Trebak M. Crosstalk between calcium and reactive oxygen species signaling in cancer. Cell Calcium. 2017; 63: 70-96.
Hemachandra LP, Shin DH, Dier U, Iuliano JN, Engelberth SA, Uusitalo LM, Murphy SK, Hempel N. Mitochondrial Superoxide Dismutase Has a Protumorigenic Role in Ovarian Clear Cell Carcinoma. Cancer Research. 2015; 75(22): 4973-84.
Notable Achievements
Hillman Cancer Center Senior Fellow for Innovative Cancer Research, 2022
Member, NIH Tumor Evolution, Heterogeneity and Metastasis (TEHM, formerly TEM) Study Section, 2020-2025
Dean’s Award for Excellence in Teaching, Penn State College of Medicine, 2021
Outstanding Collaborative Research Team Award, Penn State College of Medicine, 2020
Council Member & Chair of Professional Development, Society for Redox Biology and Medicine (SfRBM), 2015-2018
Scholar-in-Training Award, American Association for Cancer Research (AACR), 2010
Young Investigator Award, Society for Redox Biology and Medicine (SfRBM), 2008 & 2010
Member, Society for Redox Biology and Medicine (SfRBM), 2007-present
Member, American Association for Cancer Research (AACR), 2005-present

Division Websites

Cardiology

Endocrinology and Metabolism

Gastroenterology, Hepatology and Nutrition

General Internal Medicine

Geriatric Medicine
Hematology/Oncology

Infectious Diseases

Pulmonary, Allergy and Critical Care Medicine

Renal-Electrolyte

Rheumatology and Clinical Immunology

Contact

Department of Medicine
1218 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
Email:  chairoff@pitt.edu
Phone:  412-648-9636
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