Department of Medicine
Faculty Profiles by Division

Department of Medicine

Faculty Profiles

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photo Michael J Jurczak, PhD

Endocrinology and Metabolism

Assistant Professor of Medicine

Director of Rodent Phenotyping, Center for Metabolism and Mitochondrial Medicine

Email: jurczakm@pitt.edu

Phone: 412-648-7006

Contact
Office: 200 Lothrop Street
W1060 BST
Pittsburgh, PA 15213
 
Phone: 412-648-7006
Fax: 412-648-3290
E-mail: jurczakm@pitt.edu
Administrative Assistant:
Chelsea Dempsey
Address: W1026 Biomedical Science Tower
200 Lothrop Street
Pittsburgh, PA 15213
Email: cad183@pitt.edu
Phone: 412-648-9770
Fax: 412-648-3290
Education and Training
Education
BS, University of California Los Angeles, 2002
PhD, University of Chicago, 2008
Training
Post-Doctoral Fellow, Howard Hughes Medical Institute, Yale University, 2011
Research Interest
Dr. Jurczak’s lab is primarily interested in the relationship between nutrient excess, mitochondrial overload and the pathogenesis of metabolic diseases, such as fatty liver, insulin resistance and type 2 diabetes. Mitochondrial dysfunction and ectopic lipid accumulation in liver are both associated with insulin resistance in human subjects, but the cause and effect nature of these associations remain unclear. Dr. Jurczak’s lab is specifically interested in a mitochondrial repair mechanism called mitophagy that regulates the selective removal of damaged mitochondria via the autophagosomal pathway. Because autophagy is suppressed in mouse models of obesity and fatty liver disease, it is likely that mitophagy is similarly impaired and may contribute to the decline in mitochondrial function seen in human patients. Interestingly, a key component of the mitophagy pathway, a ubiquitin E3 ligase called Parkin, is upregulated in liver of obese mice. This change may represent a compensatory response to remove damaged mitochondria from hepatocytes or result directly from the loss of autophagy. Dr. Jurczak’s group is using a genetic approach to test whether the loss of Parkin-mediated mitophagy in liver predisposes mice to mitochondrial dysfunction, ectopic lipid accumulation and insulin resistance. The lab employs in vivo and ex vivo approaches in transgenic mouse models and specializes in using radioactive and stable metabolic isotopes to measure substrate turnover and flux.
Educational Interest
Dr. Jurczak is involved in mentoring postdoctoral fellows and clinical research fellows in the Department of Medicine, Division of Endocrinology and Metabolism.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Thapa, D., Wu, K., Stoner, M. W., Xie, B., Zhang, M., Manning, J. R., Lu, Z., Li, J. H., Chen, Y., Gucek, M., Playford, M. P., Mehta, N. N., Harmon, D., O'Doherty, R. M., Jurczak, M. J., Sack, M. N., Scott, I. The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial ß-oxidation enzyme HADHA. J Biol Chem. 2018; Epub ahead of print.
Jurczak, M. J., Saini, S., Ioja, S., Costa, D. K., Udeh, N., Zhao, X., Whaley, J. M., Kibbey, R. G. SGLT2 knockout prevents hyperglycemia and is associated with reduced pancreatic ß-cell death in genetically obese mice. Islets. 2018; 1-9.
Thapa, D., Stoner, M. W., Zhang, M., Xie, B., Manning, J. R., Guimaraes, D., Shiva, S., Jurczak, M. J., Scott, I. Adropin regulates pyruvate dehydrogenase in cardiac cells via a novel GPCR-MAPK-PDK4 signaling pathway. Redox Biol. 2018; 18: 25-32.
Flannery, C. A., Choe, G. H., Fleming, A. G., Cooke, K. M., Radford, C. C., Kodaman, P. H., Jurczak, M. J., Kibbey, R. G., Taylor, H. S. Insulin Regulates Glycogen Synthesis in Human Endometrial Glands through Increased GYS2. J Clin Endocrinol Metab. 2018; Epub ahead of print.
Xiong, J., Kawagishi, H., Yan, Y., Liu, J., Wells, Q. S., Edmunds, L. R., Fergusson, M. M., Yu, Z. X., Rovira, I. I., Birttain, E. L., Wolfgang, M. J., Jurczak, M. J., Fessel, J. P., Finkel, T. A Metabolic Basis for Endothelial-to-Mesenchymal Transition. Mol Cell. 2018; 69(4): 689-698.e7.
Lawan, A., Min, K., Zhang, L., Canfran-Duque, A., Jurczak, M. J., Camporez, J. P. G., Nie, Y., Gavin, T. P., Shulman, G. I., Hernandez-Fernando, C., Bennet, A. M. Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node that Regulates Obesity-Induced Insulin Resistance. Diabetes. 2018; 67(4): 624-635.
Ioja, S., Singamsetty, S., Corey, C., Guo, L., Shah, F., Jurczak, M. J., McVerry, B. J., Shiva, S., O'Connell, C. P. Nocturnal Hypoxia Improves Glucose Disposal, Decreases Mitochondrial Efficiency, and Increases Reactive Oxygen Species in the Muscle and Liver of C57BL/6J Mice Independent of Weight Change. Oxid Med Cell Longev. 2018; eCollection 2018.
Cobit, K. C., Camporez, J. P. G., Edmunds, L. R., Tran, J. L., Vera, N. B., Erion, D. M. N., Deo, R. C., Perry, R. J., Shulman, G. I., Jurczak, M. J., Weiss, E. J. Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling. Diabetes. 2018; 67(2): 208-221.
Pang, X. Y., Wang, S., Jurczak, M. J., Shulman, G. I., Moise, A. R. Retinol saturase modulates lipid metabolism and the prodcution of reactive oxygen species. Arch Biochem Biophys. 2017; 633: 93-102.
Lee, H. Y., Lee, J. S., Alves, T., Ladiges, W., Rabinovtich, P. S., Jurczak, M. J., Choi, C. S., Chulman, G. I., Samuel, V. T. Mitochondrial Targeted Catalase Protects Against High-Fat Diet-Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation. Diabetes. 2017; Epub ahead of print.
Sponsored Research/Activities
Title: Obesity-Associated Mitophagy Resistance
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK114012
Start Year: 2018
End Year: 2023
Title: Park2, Lipid Malabsorption and Protection from Diet-Induced Obesity
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R03 DK112044
Start Year: 2017
End Year: 2019
Title: Parkin's Role in Hepatic Mitochondrial Turnover, Steatosis and Insulin Resistance
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: K01 DK099402
Start Year: 2015
End Year: 2017
Title: Regulation of Fuel Utilization by Lysine Acetylation in the Failing Heart
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL132917
Start Year: 2017
End Year: 2021
Title: Regulation of Hepatic Mitochondrial Homeostasis and Fuel Metabolism by Acetylation
Role: Co-Investigator
Funding Agency: American Diabetes Association
Start Year: 2017
End Year: 2019
Title: Identifying Mechanisms by Which a Novel Human Obesity-Risk Variant Protects Against Diabetes Using Cell and Animal Models
Role: Co-Investigator
Funding Agency: American Diabetes Association
Start Year: 2017
End Year: 2019
Title: Developing a Dual Stable Isotope Approach to Measure Lipolysis in Mice
Role: Co-Investigator
Funding Agency: Georgia Regents University/National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: U24 DK076169
Start Year: 2015
End Year: 2017
Notable Achievements
American Diabetes Association Research Grant Review Committee Member, 2016
Former Co-Director of the NIH-funded Yale Mouse Metabolic Phenotyping Center In Vivo Metabolism Core, 2011-2015
Inaugural Invited Lecture, Committee on Molecular Metabolism and Nutrition Alumni Lecture, University of Chicago, 2011
Commitee Award for Outstanding Performance inthe General Field of Molecular Metabolism and Nutrition, University of Chicago, 2008