Office:	UPMC Montefiore Hospital, NW628
	3459 Fifth Avenue
	Pittsburgh, PA 15213
Phone:	412-624-7225
Fax:	412-624-1670
E-mail:	koenigshoffm@upmc.edu

Education
	MD, Justus-Liebig-University of Giessen and University of Hamburg, Germany, 2003
	Dr. Med., University of Giessen, Germany, 2004
	Dr. Phil/PhD, Justus-Liebig University Giessen, Germany, 2009

Training
	Residency/Fellowship - Internal Medicine/Pulmonary, University Hospital Giessen, Department of Medicine, Germany, 2008
	Postodoctoral Fellow, Pulmonary, Department of Medicine, University of Giessen Lung Center, Germany, 2010

Our research focuses on deciphering mechanisms involved in lung repair and regeneration, with the aim to identify novel therapeutic targets relevant for age-related chronic lung diseases, such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD). Our translational research program focuses on the comprehensive characterization of primary lung epithelial (stem) cells from experimental models and human tissue samples from patients with chronic lung disease. we aim to identify and investigate target signaling pathways that impact cellular mechanisms we identified the developmental WNT signaling pathway as a potent contributor to impaired lung repair and epithelial cell reprogramming, which is amenable to therapy and have further characterized features of epithelial cell reprogramming, such as cellular senescence. We further pioneered and apply patient-derived 3D Lung Tissue Cultures that allow to further validate and test potential novel drugs in an individualized fashion.

Dr. Königshoff is highly committed to teach and educate early career professionals. As a mentor and supervisor, Dr. Königshoff sees her major responsibility in fostering curiosity and ambition, advance personal and professional knowledge and skill sets, and expose students and trainees to novel approaches and the opportunities of an academic career. She aims to support her trainees and team members by finding their individual career path, prepare them for the challenges of an academic career and provide guidance throughout. She has directed an international MD/PhD graduate program and is actively involved in PhD, MD, and physician-scientist training programs, Dr. Königshoff teaches seminars and small classrooms workgroups and serves as (co)-mentor on F31, F32, T32 training grant awards. Dr. Königshoff further regularly hosts undergraduate students. Her lab is composed of a multi-disciplinary group of people from different backgrounds and cultures with the guiding principle that diverse viewpoints and perspectives will lead to more creative and innovative, and thus better, science.

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Selected Publications: