Department of Medicine
Faculty Profiles by Division

Department of Medicine

Faculty Profiles

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photo Ruya Liu, MD, PhD

Endocrinology and Metabolism

Research Assistant Professor

Email: rul36@pitt.edu

Phone: 412-648-9770

Contact
Office: 200 Lothrop Street
W1054 Biomedical Science Tower
Pittsburgh, PA 15213
 
Phone: 412-648-9770
Fax: 412-648-3290
E-mail: rul36@pitt.edu
Administrative Assistant:
Emily Welsh
Address: 200 Lothrop Street
W1026 Biomedical Science Tower
Pittsburgh, PA 15213
Email: ejw74@pitt.edu
Phone: 412-648-9770
Fax: 412-648-3290
Education and Training
Education
MD, Beihua University, China, 2007
PhD, Shanghai Jiaotong University, China, 2012
Training
Intern, Faculty of Medicine, Beihua University, China, 2007
Research Fellow, Massachusetts General Hospital, 2013
Postdoctoral Fellow, Houston Methodist Research Institute, 2014
Postdoctoral Associate, Baylor College of Medicine, 2015
Research Interest
Dr. Liu's research has focused on the molecular modulation of cardiomyocyte homeostasis and cardiac metabolism. Her research has revealed the imperative roles of Tead1 — a downstream effector of Hippo pathway — in the maintenance of normal adult heart contractility. This effort utilized a cardiac-specific inducible Tead1 knock-out allele and demonstrated Tead1’s critical function in sarcoplasmic reticulum Calcium homeostasis, cell cycle progression, and cellular bioenergetics. Currently, the Liu Lab is working on exploring the novel regulators of cardiomyocyte cell cycle, hypertrophy, and regeneration.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Liu, R., Jagannathan, R., Sun, L., Li, F., Yang, P., Lee, J., Negi, V., Garcia-Perez, E.M., Shiva, S., Yechoor, V.K., Moulik, M. Tead1 is essential for mitochondrial function in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2020; 319(1): H89-H99.
Liu, R., Xiong, X., Nam, D., Yechoor, V., Ma, K. SRF-MRTF signaling suppresses brown adipocyte development by modulating TGF-ß/BMP pathway. Mol Cell Endocrinol. 2020; 110920.
Liu, R., Jagannathan, R., Li, F., Lee, J., Balasubramanyam, N., Kim, B. S., Yang, P., Yechoor, V. K., Moulik, M. Tead1 is required for perinatal cardiomyocyte proliferation. PLoS One. 2019; 14(2): e0212017.
Liu, R., Lee, J., Kim, B. S., Wang, Q., Buxton, S. K., Balasubramanyam, N., Kim, J. J., Dong, J., Zhang, A., Li, S., Gupte, A. A., Hamilton, D. J., Martin, J. F., Rodney, G. G., Coarfa, C., Wehrens, X. HT., Yechoor, V. K., Moulik, M. Tead1 is required for maintaining adult cardiomyocyte function and its loss results in lethal dilated cardiomyopathy. JCI Insight. 2017; 2(17): e93343.
Sponsored Research/Activities
Title: TEAD1 as a Novel Regulator of Mitochondrial Function in Cardiomyocytes
Role: Principal Investigator
Funding Agency: American Heart Association
Start Year: 2019
End Year: 2022
Title: Tead1 and Cardiac Adaptation
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01
Start Year: 2019
End Year: 2024
Title: Circadian Clock and Beta Cell Stress Adaptation
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK097160
Start Year: 2018
End Year: 2019
Notable Achievements
Basic Cardiovascular Sciences (BCVS) Abstract Travel Grant, AHA Scientific Sessions, 2018
Keystone Symposia Scholarship (NHLBI)- Mitochondria, Metabolism and Heart Failure, 2015
1st Place Best Presentation, Department of Medicine Housestaff Research Symposium, Baylor College of Medicine, 2015