Department of Medicine
Faculty Profiles by Division

Department of Medicine

Faculty Profiles

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photo Michael A. Mathier, MD


Professor of Medicine

Clinical Director, Heart & Vascular Service Line


Office: UPMC Heart & Vascular Institute
200 Lothrop Street
Pittsburgh, PA 15213
Administrative Assistant:
Patricia Neary
Phone: 412-647-2695
Fax: 412-647-0595
Education and Training
BA, University of Pennsylvania, 1986
MD, Columbia College of Physicians and Surgeons, 1990
Internal Medicine, Massachusetts General Hospital, 1993
Cardiology, Massachusetts General Hospital, 1997
Cardiac Transplantation, Massachusetts General Hospital, 1997
Research Interest
My research is directed at clinical studies of emerging therapies in heart failure and pulmonary hypertension patients.
Clinical Interest
I am interested in optimal and efficient care of patients across the entire spectrum of heart failure, from systematic approaches to outpatient populations to mechanical support and transplant for patients with advanced disease. In addition, I focus on the care of patients with all forms of pulmonary hypertension, with a special interest in right heart failure. For both the heart failure and pulmonary hypertension populations we are able to offer the full range of available therapies, including investigational treatments, delivered in a multidisciplinary framework.
Educational Interest
I am active in education for students, trainees and faculty. I have served as program director for the cardiovascular fellowship program and am currently an associate program director. I oversee an on line cardiovascular board review course and lecture annually at the ACC's national review course. I direct an organization focused on community outreach, screening and education regarding cardiovascular disease and its prevention.
For my complete bibliography, Click Here.
Selected Publications:
Chakinala, M., Feldman, J., Rischard, F., Mathier, M., Broderick, M., Leedom, N., Laliberte, K., White, R.J. Transition from Parenteral to Oral Treprostinil in Pulmonary Arterial Hypertension. Journal of Heart and Lung Transplantation. 2016.
Coons, J.C., Miller, T., Simon, M.A., Ishizawar, D.C., Mathier, M.A. Oral treprostinil for the treatment of pulmonary arterial hypertension in patients transitioned from parenteral or inhaled prostacyclins: case series and treatment protocol. Pulm Circ. 2016; 6(1): 132-35.
Rusiecki, J., Rao, Y., Cleveland, J., Rhinehart, Z., Champion, H.C., Mathier, M.A. Sex and menopause differences in response to tadalafil: 6-minute walk distance and time to clinical worsening. Pulm Circ. 2015 Dec. 2015; 5(4): 701-6.
Ryo, K., Goda, A., Onishi, T., Delgado-Montero, A., Tayal, B., Champion, H.C., Simon, M.A., Mathier, M.A., Gorcsan III, J. Characterization of right ventricular remodeling in pulmonary hypertension associated with patient outcomes by 3-dimensional wall motion tracking echocardiography. Circ Cardiovasc Imaging 2015 June. 2015; 8(6).
Jentzer, J.C., Mathier, M.A. Pulmonary Hypertension in the Intensive Care Unit. J Intensive Care Med 2015 May 5. 2015.
Jessup, M., Ardehali, R., Konstam, M.A., Manno, B.V., Mathier, M.A., McPherson, J.A., Sweitzer, N.K. COCATS 4 Task Force 12: Training in Heart Failure. J Am Coll Cardiol. 2015; 65(17): 1866-76.
Batal, O., Dardari, Z., Costabile, C., Gorcsan III, J., Arena, V.C., Mathier, M.A. Prognostic Value of Pericardial Effusion on Serial Echocardiograms in Pulmonary Arterial Hypertension. Echocardiography Feb 2015. 2015.
Vanderpool, R.R., Pinsky, M.R., Naeije, R., Deible, C., Kosaraju, V., Bunner, C., Mathier, M.A., Lacomis, J., Champion, H.C., Simon, M.A. RV-pulmonary arterial coupling predicts outcome in patients referred for pulmonary hypertension. Heart. 2015; 101(1): 37-43.
Wong, T.C., Piehler, K.M., Zareba, K.M., Lin, K., Phrampus, A., Patel, A., Moon, J.C., Ugander, M., Valeti, U., Holtz, J.E., Fu, B., Chang, C.C., Mathier, M., Kellman, P., Butler, J., Gheorghiade, M., Schelbert, E.B. Myocardial damage detected by late gadolinium enhancement cardiovascular magnetic resonance is associated with subsequent hospitalization for heart failure. J Am Heart Assoc. 2013; 2(6): e000416.
Palmer, B., Lampert, B., Mathier, M.A. Management of Right Ventricular Failure in Pulmonary Hypertension (and After LVAD Implantation). Curr Treat Options Cardiovasc Med. 2013; 15(5): 533-43.
Sponsored Research/Activities
Title: Dimethyl Fumarate in Systemic Sclerosis-Associated Pulmonary Arterial Hypertension
Role: Co-Investigator
Funding Agency: National Institute of Arthristis, Muscoskel, & Skin Disease
Grant Number: R21 AR069285
Start Year: 2017
End Year: 2019
Title: Network Management Core (NEMO) for the Pulmonary Trials Cooperative (PTC)
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: U01 HL128954
Start Year: 2015
End Year: 2020
Notable Achievements
UPMC Award for Commitment and Excellent in Service (ACES), 2013
Pittsburgh Magazine Best Doctors, 2012-19
Member, Academy of Master Educators, Univ of Pgh School of Medicine, 2013