Department of Medicine
Faculty Profiles by Division

Department of Medicine

Faculty Profiles

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photo Satdarshan (Paul) Singh Monga, MD


Professor of Pathology and Medicine

Endowed Chair for Experimental PAthology

Vice Chair and Chief of the Division of Experimental Pathology

Assistant Dean & Co-Director of the Medical Scientist Training Program

Director, Pittsburgh Liver Research Center

Director of Cellular Approaches to Tissue Engineering & Regeneration (CATER) Program

Associate Director, University of Pittsburgh Drug Discovery Institute (UPDDI)


Phone: 412-648-8842

Office: University of Pittsburgh Department of Pathology
200 Lothrop Street, S422 BST
Pittsburgh, PA 15261
Phone: 412-648-8842
Fax: 412-648-1916
Administrative Assistant:
Amanda Bytzura
Address: S414 BST
200 Lothrop Street
Pittsburgh, PA 15261
Phone: 412-648-8842
Fax: 412-648-1916
Education and Training
F.Sc, MM Modi College, Patiala, Punjab, India, 1988
MD, Dayanand Medical College & Hospital, University, Chandigarh, India, 1992
Research Interest
The Monga lab is focused on understanding the molecular and cellular basis of normal liver characteristics such as development, regeneration, metabolism and growth as well as liver pathologies such as neoplasms (HCC and hepatoblastoma), fibrosis, cirrhosis, alcoholic liver disease, non-alcoholic fatty liver disease, and others. This research focus incorporates studies on cell proliferation, adhesion, differentiation, invasion, apoptosis, metabolism, and on stem cells in adult, fetal, and embryonic livers.
For my complete bibliography, Click Here.
Selected Publications:
Adebayo Michael AO, Ko S, Tao J, Moghe A, Yang H, Xu M, Russell JO, Pradhan-Sundd T, Liu S, Singh, Poddar M, Monga JS, Liu P, Oertel M, Ranganathan S, Singhi A, Rebouissou S, Zucman-Rossi J, Ribback S, Calvisi D, Qvartskhava N, Gorg B, Haussinger D, Chen X, Monga SP. Wnt-ß-catenin-GS-glutamine-mTORC1 axis in metabolic zonation and ß-catenin-mutated liver tumors offers novel therapeutic opportunities. Cell Metabolism. 2019.
Monga SP. Liver regeneration in 2018. Updates on hepatic homeostasis and the many tiers of hepatobiliary repair. Nat Rev Gastroenterol Hepatol. 2018.
Russell JO, Monga SP. Wnt/ß-catenin signaling in liver pathobiology. Annu Rev Pathol. 2018.
Prexiosi M, Okabe H, Poddar M, Singh S, Monga SP. Endothelial Wnts regulate ß-catenin signaling in murine liver zonation and regeneration: A sequel to the Wnt-Wnt situation. Hepatol Commun, e-collection, PubMed. 2018.
Preziosi ME, Monga SP. Update on the Mechanisms of Liver Regeneration. Semin Liver Dis. 2017; 37(2): 141-151.
Monga SP. ß-Catenin signaling and roles in liver homeostasis, injury and tumorigenesis. Gastroenterology. 2015; 148 (7): 1294-1310.
Russell JO, Lu WY, Okabe H, Abrams M, Oertel M, Poddar M, Singh S, Forbes SJ, Monga SP. Hepatocyte-specific ß-catenin deletion during severe liver injury provokes cholangiocytes to differentiate into hepatocytes. Hepatology. 2018.
Pradhan-Sundd T, Zhou L, Vats R, Jiang A, Molina L, Singh S, Poddar M, Russell JM, Stolz DB, Oertel M, Apte U, Watkins S, Ranganathan S, Nejak-Bowen KN, Sundd P, Monga SP. Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis. Hepatology. 2017.
Kikuchi A, Pradhan-Sundd T, Singh S, Nagarajan S, Loizos N, Monga SP. Platelet-Derived Growth Factor Receptor ? Contributes to Human Hepatic Stellate Cell Proliferation and Migration. Am J Pathol. 2017.
Tao J, Zhang R, Singh S, Poddar M, Xu E, Oertel M, Chen X, Ganesh S, Abrams M, Monga SP. Targeting ß-catenin in hepatocellular cancers induced by co-expression of mutant ß-catenin and K-Ras in mice. Hepatology. 2016.
Notable Achievements
Elected to American Society for Clinical Investigations (ASCI), 2009
Endowed Chair for Experimental Pathology, University of Pittsburgh, 2012
Winner of the Outstanding Investigator Award, ASIP (2014), 2013
Recipient of the Robert E. Stowell Lectureship, UC Davis, Department of Pathology, 2016
Fellow of American Association for the Study of the Liver Diseases (FAASLD), 2016
Dr. Michael Gerber Memorial Lecture, Tulane University, New Orleans, LO, 2017
Dr. Rao Memorial Award Lecture, Northwestern University, Chicago IL, 2018
Takeda Distinguished Research Award, American Physiology Society, 2019
Secretary Treasurer, American Society of Investigative Pathology, 2016
Editor-in-Chief, Gene Expression: The Journal of Basic Liver Research (Cognizant Communication), 2015-present