Department of Medicine
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Department of Medicine

Faculty Profiles
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photo Mark E. Snyder, MD

Pulmonary, Allergy and Critical Care Medicine

Assistant Professor of Medicine

Member, Graduate Program in Microbiology and Immunology

Email: snyderme2@upmc.edu

Phone: 412-624-7225
Contact
Office: UPMC Montefiore Hospital, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-624-7225
Fax: 412-624-1670
E-mail: snyderme2@upmc.edu
Administrative Assistant:
Stacie Truszkowski
Address: UPMC Montefiore Hospital, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
Email: truszkowskisl@upmc.edu
Phone: 412-624-7225
Fax: 412-624-1670
Education and Training
Education
BA, Economics, Cornell University, 2001
MD, SUNY Stony Brook University School of Medicine, 2010
Training
Internal Medicine Residency, Columbia-New York Presbyterian Hospital, 2013
Chief Resident - Internal Medicine, Columbia-New York Presbyterian Hospital, 2014
Clinical Fellow, Pulmonary, Columbia-New York Presbyterian Hospital, 2017
Research Fellow, Pulmonary, Columbia-New York Presbyterian Hospital, 2018
Research Interest
The focus of Dr. Snyder's research is on the role of the adaptive immune system in the development of chronic rejection after lung transplantation. Chronic rejection is a progressive airway disease which remains a major limiting factor to long term survival following lung transplantation. Imbalances in the suppression of the adaptive immune system, leading to acute rejection or infection, have been implicated in the pathogenesis of chronic rejection.

Recently, Dr. Snyder identified that lung donor memory T cells, the predominant cell in the adaptive immune system, survive following transplantation and persist for weeks to months in the recipient. Furthermore, this survival of donor T cells is associated with improved short-term outcomes. Additionally, his group showed that lung allograft-infiltrating, recipient-derived T cells which migrate to the lungs following transplantation take up residency within the lung. His lab is focusing on determining the function and specificity of these tissue-resident memory T cells and if they are contributing to chronic rejection.

In addition to lung transplantation, the Snyder lab is actively investigating the role of tissue resident memory T cells on pulmonary fibrosis and chronic airway inflammation.
Clinical Interest
Dr. Snyder's main clinical interests focus on the management of patients with end stage lung disease and the care of lung transplant recipients. He manages the outpatient care of lung transplant recipients at the Falk Comprehensive Lung Center as well as providing inpatient care with the advanced lung disease service at Presbyterian Hospital.
Educational Interest
Dr. Snyder provides educational instruction on the inpatient advanced lung disease and postoperative lung transplantation services. Additionally, Dr. Snyder provides mentorship in translational investigation through his laboratory.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Snyder ME, Moghbeli K, Bondonese A, Craig A, Popescu I, Fan L, Tabib T, Lafyatis R, Chen K, Trejo Bittar HE, Lendermon E, Pilewski J, Johnson B, Kilaru S, Zhang Y, Sanchez PG, Alder JK, Sims PA, McDyer JF. Modulation of tissue resident memory T cells by glucocorticoids after acute cellular rejection in lung transplantation. J Exp Med. 2022; Apr 4;219(4): e20212059.
Szabdo PA, Levitin HM, Miron M, Snyder ME, Senda T, Yuan J, Cheng YL, Bush EC, Dogra P, Thapa P, Farber DL, Sims PA. Single cell transcriptome profiling defines activation states and interrelatedness between human blood and tissue T cells. Nature Communications. 2019; 10:4076.
Weisberg SP, Carpenter DJ, Chait M, Dogra P, Gartrell-Corrado RD, Chen AX, Campbell S, Liu W, Saraf P, Snyder ME, Kubota M, Danzi NM, Schrope BA, Rabadan R, Saenger Y, Chen X, Farber DL. Tissue-Resident Memory T Cells Mediate Immune Homeostasis in the Human Pancreas through the PD-1/PD-L1 Pathway. Cell Rep. 2019; Dec 17;29(12): 3916-3932.e5.
Snyder ME, Finlayson MO, Connors TJ, Senda T, Bush E, Carpenter D, Marboe C, Benvenuto L, Shah L, Robbins H, Hook JL, Sykes M, D'Ovidio F, Bacchaetta M, Sonett JR, Lederer DJ, Arcasoy S, Sims PA, Farber DL. Generation and persistence of human tissue-resident memory T cells in lung transplantation. Science Immunology. 2019; Mar 8; 4(33): eaav5581.
Senda T, Dogra P, Granot T, Furuhaushi K, Snyder ME, Carpenter DJ, Szabo PA, Thapa P, Miron M, Farber DL. Macroanatomical dissection of human intestinal T-cell immunity reveals site-specific changes in gut-associated lymphoid tissues over life. Mucosal Immunology. 2018; In Press.
Snyder MD, Farber DL. Thymic-Peripheral Crosstalk in Lymphodepletion Therapy. Am J Transplant. 2017; 17(8): 1970-71.
Singer JP, Peterson ER, Snyder ME, Katz PP, Golden JA, D'Ovidio F, Bacchetta M, Sonett JR, Kukreja J, Shah L, Robbins H, Van Horn K, Shah RJ, Diamond JM, Wickersham N, Sun L, Hays S, Arcasoy SM, Palmer SM, Lederer DJ. Body Composition and Mortality after Adult Lung Transplantation in the United States. Am J Respir Crit Care Med. 2014; 190(9): 1012-1021.
Sponsored Research/Activities
Title: Impact of tissue resident memory T cells on chronic rejection after lung transplantation
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: K23 HL151759
Start Year: 2020
End Year: 2025
Notable Achievements
Parker B. Francis Fellowship, 2018
Transplantation and Immunology Research Network: Fellowship Grant, 2017

Division Websites

Cardiology

Endocrinology and Metabolism

Gastroenterology, Hepatology and Nutrition

General Internal Medicine

Geriatric Medicine
Hematology/Oncology

Infectious Diseases

Pulmonary, Allergy and Critical Care Medicine

Renal-Electrolyte

Rheumatology and Clinical Immunology

Contact

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Email:  chairoff@pitt.edu
Phone:  412-648-9636
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