Department of Medicine
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Department of Medicine

Faculty Profiles
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photo Prithu Sundd, PhD

Pulmonary, Allergy and Critical Care Medicine

Associate Professor of Medicine (Tenured)

Associate Professor of Bioengineering

Email: prs51@pitt.edu

Phone: 412-648-9103
Contact
Office: Starzl Biomedical Science Tower, E1255
200 Lothrop Street
Pittsburgh, PA 15261
 
Phone: 412-648-9103
Fax: 412-648-5980
E-mail: prs51@pitt.edu
Education and Training
Education
B.Tech., Biochemical Engineering, Harcourt Butler Technological Institute, Kanpur, India, 2001
PhD, Chemical Engineering, Ohio University, 2007
Research Interest
1. Mechanisms of leukocyte rolling and arrest during inflammation.
2. Role of neutrophils in pulmonary vaso-occlusion during sickle cell disease Acute Chest Syndrome.
3. Identifying molecular mechanism of vaso-occlusion in SCD (SS) patient blood.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Jimenez, MA, Tutuncuoglu, E, Barge, S, Novelli, EM, Sunnd, P. Quantitative microfluidic fluorescence microscopy to study vaso-occlusion in Sickle Cell Disease. Haematologica. 2015; May 14.
Bennewitz, MF, Watkins, SC, Sundd, P. Quantitative intravital two-photon excitation microscopy reveals absence of pulmonary vaso-occlusion in unchallenged Sickle Cell Disease mice. Intravital. 2014; Jul 7;3(2): e29748.
Koltsova, EK, Sundd, P, Zarpellon, A, Ouyang, H, Mikulski, Z, Zampolli, A, Ruggeri, ZM, Ley, K. Genetic deletion of platelet glycoprotein Ib alpha but not its extracellular domain protects from atherosclerosis. Thrombosis and Haemostasis. 2014; Dec; 112(6): 1252-63.
Stadtmann, A, Germena, G, Block, H, Boras, M, Rossaint, J, Sundd, P, Lefort, C, Fisher, CI, Buscher, K, Gelschefarth, B, Urzainqui, A, Gerke, V, Ley, K, Zarbock, A. The PSGL-1-L-selectin signaling complex regulates neutrophil adhesion under flow. Journal of Experimental Medicine. 2013; Oct 21;210(11): 2171-80.
Sundd, P, Ley, K. Quantitative dynamic footprinting microscopy. Immunology and Cell Biology. 2013; Apr;91(4): 311-20.
Sundd, P, Pospieszalska, MK, Ley, K. Neutrophil rolling at high shear: flattening, catch bond behavior, tethers and slings. Molecular Immunology. 2013; Aug;55(1): 59-69.
Sundd, P, Gutierrez, E, Koltsova, EK, Kuwano, Y, Fukuda, S, Pospieszalska, MK, Groisman, A, Ley, K. 'Slings' enable neutrophil rolling at high shear. Nature. 2012; Aug 16;488(7411): 399-403.
Sundd, P, Pospieszalska, MK, Cheung, LS, Kostantopoulos, K, Ley, K. Biomechanics of leukocyte rolling. Biorheology. 2011; 48(1): 1-35.
Sundd, P, Gutierrez, E, Petrich, BG, Ginsberg, MH, Groisman, A, Ley, K. Live cell imaging of paxillin in rolling neutrophils by dual-color quantitative dynamic footprinting. Microcirculation. 2011; Jul;18(5): 361-72.
Sundd, P, Gutierrez, E, Pospieszalska, MK, Zhang, H, Groisman, A, Ley, K. Quantitative dynamic footprinting microscopy reveals mechanisms of neutrophil rolling. Nature Methods. 2010; Oct;7(10): 821-4.
Sponsored Research/Activities
Title: Pulmonary arteriole occlusion by platelet-neutrophil micro-emboli in Acute Chest Syndrome
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL128297
Start Year: 2021
End Year: 2025
Title: Hemopexin as a therapy for acute chest syndrome in Sickle Cell Disease
Role: Principal Investigator
Funding Agency: CSL Behring GmbH
Grant Number: DRUG
Start Year: 2021
End Year: 2022
Title: Hemopexin as a therapy for acute chest syndrome in Sickle Cell Disease
Role: Principal Investigator
Funding Agency: CSL Behring GmbH
Grant Number: DRUG
Start Year: 2021
End Year: 2022
Title: Hemopexin as a therapy for acute chest syndrome in Sickle Cell Disease
Role: Principal Investigator
Funding Agency: CSL Behring GmbH
Grant Number: DRUG
Start Year: 2020
End Year: 2022
Title: Mechanisms of Platelet Exosome-Mediated Acute Chest Syndrome in Sickle Cell Disease
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL141080
Start Year: 2019
End Year: 2023
Title: Mechanisms of Platelet Exosome-Mediated Acute Chest Syndrome in Sickle Cell Disease
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL141080
Start Year: 2019
End Year: 2023
Title: Mechanism of Platelet Extracellular Vesicle-Mediated Vaso-Occlusion in Sickle Cell Disease
Role: Principal Investigator
Funding Agency: American Heart Association
Grant Number: RES
Start Year: 2018
End Year: 2021
Title: Pulmonary Arteriole Occlusion by Platelet-Neutrophil Micro-Emboli in Acute Chest Syndrome
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL128297
Start Year: 2015
End Year: 2021
Title: Pulmonary Arteriole Occlusion by Platelet-Neutrophil Micro-Emboli in Acute Chest Syndrome
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL128297
Start Year: 2015
End Year: 2020
Title: Anti-inflammatory actions of a novel hemin-induced electrophile in Sickle Cell Disease
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R03 HL157878
Start Year: 2021
End Year: 2023
Title: Defining the systems biology of the vascular matrix in pulmonary hypertension
Role: Co-Investigator
Funding Agency: American Heart Association-National
Grant Number: RES
Start Year: 2018
End Year: 2022
Title: Inflammasome Activation in Trauma-Hemorrhagic Shock
Role: Co-Investigator
Funding Agency: National Institute of General Medical Science
Grant Number: R01 GM102146
Start Year: 2018
End Year: 2022
Title: Defining the systems biology of the vascular matrix in pulmonary hypertension
Role: Co-Investigator
Funding Agency: American Heart Association
Grant Number: RES
Start Year: 2018
End Year: 2022
Title: Inflammasome Activation in Trauma-Hemorrhagic Shock
Role: Co-Investigator
Funding Agency: National Institute of General Medical Science
Grant Number: R01 GM102146
Start Year: 2018
End Year: 2022
Title: PET Imaging of Vaso-Occlusion in Sickle Cell Disease: From Mice to Humans
Role: Co-Investigator
Funding Agency: Pittsburgh Foundation
Start Year: 2018
End Year: 2020
Title: PET Imaging of Vaso-Occlusion in Sickle Cell Disease: From Mice to Humans
Role: Co-Investigator
Funding Agency: Pittsburgh Foundation
Grant Number: RES
Start Year: 2018
End Year: 2020
Title: Hemolysis-Induced Platelet mitoROS Drives TSP1 Release and PH Pathogenesis
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL133003
Start Year: 2017
End Year: 2021
Title: Hemolysis-Induced Platelet mitoROS Drives TSP1 Release and PH Pathogenesis
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL133003
Start Year: 2017
End Year: 2021
Title: HIPPO Signaling in Pulmonary Arterial Hypertension
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL130261
Start Year: 2016
End Year: 2020
Title: PPAR-delta as a Novel Therapeuic Target in Asthma (Admin Supplement)
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R01 AI125338
Start Year: 2016
End Year: 2019

Division Websites

Cardiology

Endocrinology and Metabolism

Gastroenterology, Hepatology and Nutrition

General Internal Medicine

Geriatric Medicine
Hematology/Oncology

Infectious Diseases

Pulmonary, Allergy and Critical Care Medicine

Renal-Electrolyte

Rheumatology and Clinical Immunology

Contact

Department of Medicine
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Email:  chairoff@pitt.edu
Phone:  412-648-9636
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