Department of Medicine
Faculty Profiles by Division

Department of Medicine

Faculty Profiles

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photo Frederico G. S. Toledo, MD

Endocrinology and Metabolism

Associate Professor of Medicine

Director of Clinical Research, Center for Metabolic and Mitochondrial Medicine

Email: toledofs@upmc.edu

Phone: 412-586-9700

Contact
Office: NW807 Montefiore Hospital
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-586-9700
Fax: 412-586-9726
E-mail: toledofs@upmc.edu
Administrative Assistant:
Emily Welsh
Address: W1026 Biomedical Science Tower
200 Lothrop Street
Pittsburgh, PA 15213
Email: ejw74@pitt.edu
Phone: 412-648-9770
Fax: 412-648-3290
Education and Training
Education
MD, Federal University of Rio de Janeiro, Brazil, 1996
Training
Postdoctoral Fellowship in Physiology, Mayo Clinic, MN, 1998
Residency, Internal Medicine, University of Miami, 2002
Fellowship, Endocrinology, University of Pittsburgh Medical Center, 2004
Research Interest
Dr. Toledo’s scientific interest is the pathogenesis and treatment of diabetes mellitus. His research program is dedicated to clinical and translational research studies related to the etiology and treatment of insulin resistance in humans. His laboratory is specialized in the state-of-the-art measurements of metabolism in vivo, including clamps, IVGTTs, stable-isotope tracers, indirect calorimetry, tissue biopsies, and exercise tests. Dr. Toledo’s work has shown that mitochondrial abnormalities are linked to the pathogenesis of insulin resistance in the context of obesity, type 2 diabetes, and aging. He has also pioneered research studies of medications that improve insulin resistance and beta cell function and has been a co-investigator in the NIH-sponsored TrialNet consortium which investigates how type 1 diabetes may be prevented by immunomodulators. His research program is currently investigating the pathogenesis of pancreatitis-related diabetes to identify new possibilities of prevention and treatment. Dr. Toledo has been a Principal Investigator in studies funded by the NIH, the Dept. of Defense, and the American Diabetes Association.
Clinical Interest
Dr. Toledo's clinical interests are in the areas of diabetes and general endocrinology. He is interested in new models of care, pioneered the development of video-consultation telemedicine care in the Division of Endocrinology, and founded the CDE diabetes telemedicine clinic, which provides outpatient adult diabetes care to medically underserved areas in rural Pennsylvania.
Educational Interest
Dr. Toledo participates in the medical education of fellows, residents, and medical students. He served as Associate Program Director for the Endocrinology Fellowship Program from 2005 through 2014. Since 2007, Dr. Toledo has been the subspecialty education coordinator for endocrinology training in the internal medicine residency program.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Toledo, F.G.S., Miller, R.G., Helbling, N.L., Zhang, Y., DeLany, J.P. The Effects of Hydroxychloroquine on Insulin Sensitivity, Insulin Clearance, and Inflammation in Insulin-Resistant Adults: a Randomized Trial. Diabetes Obes Metab. 2021.
Toledo, F.G.S., Chari, S., Yadav, D. Understanding the Contribution of Insulin Resistance to the Risk of Pancreatic Cancer. Am J Gastroenterol. 2021.
Gancheva S., Ouni, M., Jelenik, T., Koliaki, C., Szendroedi, J., Toledo, F.G.S., Markgraf, D.F., Pesta, D.H., Mastrotot, L., De Filippo, E., Herder, C., Jahnert, M., Weiss, J., Strassburger, K., Schlensak, M., Schurmann, A., Roden, M. Dynamic changes of muscle insulin sensitivity after metabolic surgery. Nat Commun. 2019; 10(1): 4179.
Toledo, F.G.S., Johannsen, D.L., Covington, J.D., Bajpeyi, S., Goodpaster, B., Conley, K.E., Ravussin, E. Impact of prolonged overfeeding on skeletal muscle mitochondria in healthy individuals. Diabetologia. 2018; 61(2): 466-75.
Toledo, F.G.S., Dube, J.J., Goodpaster, B.H., Stefanovic-Racic, M., Coen, P.M., DeLany, J.P. Mitochondrial Respiration is Associated with Lower Energy Expenditure and Lower Aerobic Capacity in African American Women. Obesity (Silver Spring). 2018; 26(5): 903-9.
Ryan, J.P., Karim, H.T., Aizenstein, H.J., Helbling, N.L., Toledo, F.G.S. Insulin sensitivity predicts brain network connectivity following a meal. Neuroimage. 2018; 171: 268-76.
Arslanian, S., Kim, J.Y., Nasr, A., Bacha, F., Tfayli, H., Lee, S., Toledo, F.G.S. Insulin sensitivity across the lifespan from obese adolescents to obese adults with impaired glucose tolerance: Who is worse off?. Pediatr Diabetes. 2018; 19(2): 205-11.
Wasko, M.C., McClure, C.K., Kelsey, S.F., Huber, K., Orchard, T., Toledo, F.G. Antidiabetogenic effects of hydroxychloroquine on insulin sensitivity and beta cell function: a randomised trial. Diabetologia. 2015; 58(10): 2336-43.
Toledo, F.G., Ruppert, K., Huber, K.A., Siminerio, L.M. Efficacy of the Telemedicine for Reach, Education, Access, and Treatment (TREAT) model for diabetes care. Diabetes Care. 2014; 37(8): 179-80.
Toledo, F.G. Mitochondrial involvement in skeletal muscle insulin resistance. Diabetes. 2014; 63(1): 59-61.
Sponsored Research/Activities
Title: Study of Muscle, Mobility and Aging (SOMMA)
Role: Co-Investigator
Funding Agency: California Pacific Medical Center/ National Institute of Aging
Grant Number: R01 AG059416
Start Year: 2019
End Year: 2020
Title: A Phase II Trial of Metformin for Pulmonary Hypertension in Heart Failure with Preserved Ejection Fraction
Role: Co-Investigator
Funding Agency: National Institute of Aging
Grant Number: R01 AG058659
Start Year: 2018
End Year: 2023
Title: Insulation Modulation of fMRI Connectivity and Food Reward
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R03 DK108976
Start Year: 2017
End Year: 2020
Title: Dynamic PET Imaging in Skeletal Muscle and Adipose Tissue to Explore Mechanisms of Lower Peripheral Glucose Uptake in African American Women
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK112700
Start Year: 2017
End Year: 2020
Title: Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer: Coordinating and Data Management Center (CSCDPC_CDMC)
Role: Co-Investigator
Funding Agency: MD Anderson Cancer Center
Grant Number: U01 DK108328
Start Year: 2016
End Year: 2018
Title: Nitrite Benefits to Mediate Fatigability in Older HFpEF Patients
Role: Co-Investigator
Funding Agency: National Institute of Aging
Grant Number: R01 AG051637
Start Year: 2016
End Year: 2017
Title: Decreased Fat Oxidation - Metabolic Inflexibility in African American Women
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R56 DK091462
Start Year: 2015
End Year: 2017
Title: Neutrophil Elastase Inhibition as Adjunctive Therapy to Improve Glucometabolic Variables in Obese, Insulin-Resistant Type 2 Diabetic Patients
Role: Co-Investigator
Funding Agency: Allegheny-Singer Research Institute/Astra Zeneca
Start Year: 2015
End Year: 2017
Title: LABS Sub-Study: Mechanisms of Durability of Type 2 Diabetes Remission
Role: Co-Investigator
Funding Agency: Oregon Health Sciences/National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK103842
Start Year: 2014
End Year: 2019